The role of parent phenotype in parent-mediated language interventions for autism

父母表型在父母介导的自闭症语言干预中的作用

• 批准号: 9098682
• 负责人: Megan Y Roberts
• 金额: $ 72.4万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9098682
• 关键词: Affect; Age-Months; Area; Autistic Disorder; Behavioral; Behavioral Research; Categories; Centers for Disease Control and Prevention (U.S.); Characteristics; Child; Child Language; Clinical; Cognitive; Communication; Data; Development; Developmental Disabilities; Disease; Early Intervention; Educational process of instructing; Enrollment; Goals; Health; Home environment; Honey; Impairment; Individual; Interdisciplinary Study; Intervention; Language; Language Development; Learning; Maintenance; Measures; Mediating; Mission; Modeling; Monitor; Mothers; National Institute on Deafness and Other Communication Disorders; Outcome; Parents; Personality; Phenotype; Procedures; Process; Public Health; Randomized; Randomized Controlled Trials; Research; Scientist; Severities; Skills Development; Source; Strategic Planning; Stress; Testing; Training; Treatment outcome; autism spectrum disorder; base; cognitive skill; cost effective; design; dosage; improved; parental influence; parental role; post intervention; skill acquisition; skills; social; social cognition; social communication; success; trait

 DESCRIPTION (provided by applicant): High dosage of early intervention is critical to language skill development in young children with autism spectrum disorders (ASD) (Dawson et al., 2010) and including parents is a cost-effective approach to maximize intervention dosage. However, parent-mediated interventions have inconsistent effects on parent and child outcomes (Oono, Honey, & McConachie, 2013). This variability is likely because parents do not have the same training as clinicians and little effort has been spent examining parent characteristics that may influence their ability to implement different types of intervention strategies. Given the known cognitive, personality and language features (Broad Autism Phenotype, BAP) present among many parents of children with ASD, examining the relationship between BAP traits in parents and their implementation of different parent-mediated intervention strategies is an important first step in identifying potential sources of variability in parent-mediated interventio outcomes. The objective of the proposed study is to examine how BAP traits influence parent use of language intervention strategies and subsequent child language skills. The central hypothesis is that the parental BAP traits will be associated with: (a) differential use of languag intervention strategies and (b) child language skills. The specific aims include determining the extent to which: (a) BAP traits and type of parent-mediated intervention are associated with mother use of language intervention strategies and subsequent child language skills, (b) BAP traits moderate the relationship between intervention type and mother use of language intervention strategies, and (c) mother social cognitive skills are associated with their use of language intervention strategies and their children's language skills. The proposed study will enroll 108 children with ASD 18 - 36 months old and their mothers. Mother-child dyads will be randomly assigned to one of two parent-mediated intervention strategies that are contrasted in their theoretical approach (responsive-developmental, directive-behavioral). Mother-child dyads will be assessed before randomization (pre-test), after intervention (post-test) and 3 months after the end of intervention to monitor maintenance. Children in both groups will receive 8 weekly intervention sessions at home using the same experimental procedures. The proposed research is significant because it will be the first examination of the impact of BAP traits on bot parent and child outcomes of two different parent-mediated intervention strategies (directive, responsive). Understanding the effects of BAP traits on parent use of intervention strategies and subsequent child language skills is a key step in customizing parent-mediated interventions based on parent characteristics. The long-term positive effect of the proposed research is to improve language outcomes of interventions for children with autism by tailoring parent-mediated interventions that capitalize on parental strengths.

 描述（由申请人提供）：高剂量的早期干预对患有自闭症谱系障碍（ASD）的幼儿的语言技能发展至关重要（Dawson等人，2010年），包括父母是一个具有成本效益的方法，以最大限度地提高干预剂量。然而，父母介导的干预对父母和孩子的结果有不一致的影响（Oono，蜂蜜，& McConachie，2013）。这种差异可能是因为父母没有接受过与临床医生相同的培训，并且很少花费精力来检查可能影响其实施不同类型干预策略的能力的父母特征。鉴于已知的认知，人格和语言特征（广泛自闭症表型，BAP）存在于许多ASD儿童的父母中，检查父母的BAP特征与他们实施不同的父母介导的干预策略之间的关系是识别父母介导的干预结果的潜在变异来源的重要的第一步。本研究的目的是探讨BAP特质如何影响父母使用语言干预策略和随后的儿童语言技能。核心假设是父母的BAP特质将与：（a）语言干预策略的差异使用和（B）儿童的语言技能相关。具体目标包括确定在何种程度上：（a）BAP特质和父母中介干预的类型与母亲使用语言干预策略和随后的儿童语言技能相关，（B）BAP特质调节干预类型和母亲使用语言干预策略之间的关系，母亲的社会认知能力与其语言干预策略的使用及子女的语言技能有关。这项研究将招募108名18 - 36个月的ASD儿童及其母亲。母子二人组将被随机分配到两个父母介导的干预策略之一，这两个策略在理论方法上是相反的（反应-发展，指导-行为）。将在随机化前（试验前）、干预后（试验后）和干预结束后3个月评估母子二人组，以监测维持情况。两组儿童将在家中接受8次每周一次的干预，使用相同的实验程序。拟议的研究是重要的，因为它将是第一次检查的BAP性状对机器人的父母和孩子的结果的两种不同的父母介导的干预策略（指令，响应）的影响。了解BAP特质对父母使用干预策略和随后的儿童语言技能的影响是根据父母特征定制父母介导干预措施的关键一步。拟议的研究的长期积极影响是通过利用父母的优势来调整父母介导的干预措施，以改善自闭症儿童干预措施的语言效果。