Adminsitrative Core

我们的COBRE应用程序的目标是建立一个多学科中心， 加强阿尔弗雷德一世的生物医学研究基础设施。杜邦儿童医院（AIDHC） 特拉华州州立大学（DSU）在血红蛋白病研究的特定领域所形成的 特拉华州镰状细胞综合研究中心。该中心包括两个机构， 提高来自几个互补学科的个别调查人员的能力，使他们能够联合收割机开展工作 在镰状细胞病中，涵盖了从Ii珠蛋白基因的基因编辑和鉴定 使用下一代测序的中风遗传预测因子，试图解构 SCD相关疼痛的炎症，以确定儿童SCD的心理社会风险。的 管理核心将证明3名目标研究者和2名开展初步研究的研究者 有专门为满足其个人需求而量身定制的研究、指导和教育方案。 已经制定了监测他们逐步成为成功的独立调查员的基准。 阐明了我们实现自给自足的方案路径，包括为实现自给自足而将采取的步骤 临界学术质量。最后，执行委员会、指导单位、 内部和外部咨询委员会及其各自的监督责任和作用如下： 包括PD/PI在内。

The objective of our COBRE application is the establishment of a multidisciplinary Center which will strengthen the biomedical research infrastructures of the Alfred I. duPont Hospital for Children (AIDHC) and Delaware State University (DSU) in the specific area of Hemoglobinopathy research by the formation of the Delaware Comprehensive Sickle Cell Research Center. This Center encompassing both Institutions will enhance the ability of individual investigators from several complementary disciplines to combine their efforts in Sickle Cell Disease covering a territory ranging from gene editing of the Ii Globin gene and identifying genetic predictors of stroke using next generation sequencing, to an attempt at the deconstruction of the role of inflammation in SCD-related pain, to the identification of psychosocial risk in pediatric SCD. The Administrative Core will demonstrate that the 3 Target Investigators and the 2 Investigators with Pilot studies have had research, mentoring and educational programs specifically tailored to meet their individual needs. Benchmarks to monitor their progression into successful independent investigators have been established. Our programmatic path to self-sufficiency is articulated, including the steps that will be undertaken to attain a critical academic mass. Finally the role and composition of the Executive Committee, Mentoring Units, Internal and External Advisory Committees and their individual oversight responsibilities and roles are described, including that of the PD/PI.