2018 Barriers of the CNS Gordon Research Conference and Gordon Research Seminar

2018 CNS戈登研究会议和戈登研究研讨会的障碍

• 批准号: 9542556
• 负责人: William Elmquist
• 金额: $ 2.39万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9542556
• 关键词: Address; Alzheimer' s Disease; Bioinformatics; Biomedical Engineering; Blood; Blood - brain barrier anatomy; Blood Circulation; Brain; Brain Neoplasms; Central Nervous System Diseases; Clinical; Collaborations; Communities; Complex; Computer Simulation; Development; Diagnosis; Diagnostic; Disease; Drug Delivery Systems; Environment; Epithelial; Faculty; Feedback; Fostering; Funding; Goals; Growth and Development function; Health; Homeostasis; Immune system; International; Knowledge; Lead; Maintenance; Measures; Mentors; Mentorship; Metastatic malignant neoplasm to brain; Methods; Molecular; Neuraxis; New Hampshire; Participant; Pharmaceutical Preparations; Postdoctoral Fellow; Public Health; Regulation; Request for Applications; Request for Proposals; Research; Research Methodology; Research Personnel; Role; Science; Scientist; Senior Scientist; Structure; Students; Technology; Therapeutic; career; college; data mining; fluid flow; genetic signature; improved; innovation; insight; interest; intravital microscopy; mathematical model; meetings; multidisciplinary; nervous system disorder; neurotoxic; new technology; novel; novel strategies; palliative; peer; posters; prevent; symposium; transcriptome; tumor growth

Project Summary / Abstract This proposal requests support for partial funding of the 2018 “Barriers of the Central Nervous System (CNS)” GRC and GRS that will be held at Colby Sawyer College, New Hampshire, on June 16-17, 2018 (GRS) and June 17-22, 2018 (GRC). The overall goal of this international conference is to improve understanding of the highly complex cellular and molecular mechanisms regulating the function of the endothelial (e.g. blood-brain barrier (BBB)) and epithelial (e.g. blood-CSF barrier (BCSFB)) brain barriers in development, maintenance and disease. The 2018 meetings will achieve this goal by covering major aspects of CNS barrier sciences and by making a special effort to include novel research methodology such as advanced intravital microscopy, mathematical modelling, bioinformatics and bioengineering; which will allow participants to obtain insights in brain barrier function from novel angles. This interdisciplinary knowledge exchange will be fostered by invited talks and daily poster presentations. The meeting will start with a keynote session on the role of the brain barriers in regulating CNS immune privilege and conclude with a trendsetting keynote session on chip technology for bioengineering the brain barriers. An additional 7 sessions will address: i) the role of brain barriers in CNS fluid flow, ii) the brain barriers in development and homeostasis, iii) brain barriers bioinformatics including introduction of a novel data-mining platform, the BBBHub, iv) molecular mechanisms regulating barrier integrity, v) the role of brain barriers in tumor growth and brain metastases, vi) novel concepts in drug delivery across the brain barriers, and, vii) brain barrier microenvironment in health and disease. The GRC Barriers of the CNS stands out from other brain barriers conferences by bringing together a multidisciplinary group of senior and junior, academic and non-academic, basic and clinical scientists from around the world. The conference provides a protected environment for presenting ongoing and unpublished research promoting new ideas and novel interdisciplinary and translational collaborations. The preceding 2-day “Barriers” GRS is organized by junior investigators at the postdoctoral level and is intended to introduce younger scientists (postgraduate students, post-docs, junior faculty) to the field's methods and issues and to facilitate networking and provide mentorship opportunities. This application addresses a major public health concern, diseases of the CNS. Improving our knowledge regarding brain barrier structure and function is prerequisite to overcome these barriers to achieve appropriate diagnosis and therapy of neurological disorders ranging from brain tumors to Alzheimer's disease, which is presently limited to symptomatic and palliative measures. Instructing young researchers to think of innovative and novel solutions and to bridge disciplinary interfaces will advance the capacity to bring new approaches to realize the untapped potential for the treatment of CNS disease.

项目总结/摘要 该提案要求支持2018年“中枢神经系统障碍”的部分资金 (CNS)“GRC和GRS将于2018年6月16日至17日在新罕布什尔州的科尔比索耶学院举行 (GRS)和2018年6月17日至22日（GRC）。本次国际会议的总体目标是提高 了解调节细胞功能的高度复杂的细胞和分子机制， 内皮（例如血脑屏障（BBB））和上皮（例如血-CSF屏障（BCSFB））脑屏障， 发育、维持和疾病。2018年的会议将通过涵盖主要方面来实现这一目标 的CNS屏障科学，并作出特别努力，包括新的研究方法， 先进的活体显微镜，数学建模，生物信息学和生物工程;这将使 参与者从新的角度获得对脑屏障功能的见解。这种跨学科的知识 并会透过邀请讲座及每日海报展示，促进交流。 会议将以关于脑屏障在调节CNS免疫中的作用的主题会议开始， 特权和结束与芯片技术的生物工程大脑的趋势基调会议 隔栏.另外7个会议将讨论：i）脑屏障在CNS液体流动中的作用，ii）脑屏障 在发展和体内平衡，三）大脑障碍生物信息学，包括引进一种新的数据挖掘 平台，BBBHub，iv）调节屏障完整性的分子机制，v）脑屏障在 肿瘤生长和脑转移，vi）穿过脑屏障的药物递送的新概念，和，vii）脑 健康和疾病中的屏障微环境。 CNS的GRC屏障从其他脑屏障会议中脱颖而出，汇集了一个 多学科小组的高级和初级，学术和非学术，基础和临床科学家从 世界各地会议提供了一个受保护的环境， 研究促进新的想法和新的跨学科和翻译合作。 前两天的“障碍”GRS由博士后水平的初级研究者组织， 旨在介绍年轻的科学家（研究生，博士后，初级教师）到该领域的 方法和问题，并促进联网和提供指导机会。 本申请解决了一个主要的公共卫生问题，CNS疾病。提高我们的知识 了解脑屏障的结构和功能是克服这些障碍，实现适当的 诊断和治疗神经系统疾病，从脑肿瘤到阿尔茨海默病， 目前仅限于对症和姑息措施。指导年轻研究人员思考创新 和新的解决方案和桥梁学科接口将提高能力，使新的方法， 实现治疗CNS疾病的未开发潜力。