Development of the Enteric Nervous System: Cells, Signals, Genes, and Therapy

肠神经系统的发育：细胞、信号、基因和治疗

• 批准号: 9541099
• 负责人: ALLAN M GOLDSTEIN
• 金额: $ 1.96万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-15 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9541099
• 关键词: Area; Attention; Award; Birds; Boston; Cell Therapy; Cells; Cellular biology; Childhood; Collaborations; Congenital Megacolon; Country; Development; Developmental Biology; Diagnosis; Disease; Distal; Enteral; Enteric Nervous System; Event; Faculty; Fostering; Functional disorder; Future; Gastroenterologist; Goals; Grant; Growth; Hong Kong; Human; International; Intestines; Knowledge; Lead; London; Maintenance; Mentors; Mentorship; Molecular Biology; Morbidity - disease rate; Neuropathy; New York; Participant; Pathologist; Productivity; Research Personnel; Rodent; Science; Scientist; Signal Transduction; Stem cells; Structure; Surgeon; Time; Travel; Underrepresented Minority; Woman; Zebrafish; base; career; career development; cost; design; expectation; gene therapy; genetic analysis; interest; meetings; member; nervous system development; novel; public health relevance; senior faculty; success; symposium; systems research

Project Summary/Abstract Over the past 20 years, remarkable progress has been made in our understanding of the enteric nervous system (ENS) and of the congenital and acquired neurointestinal diseases that result from abnormal development or maintenance of the ENS. Many of the advances in understanding ENS development have been made by cell, molecular, and developmental biology studies and genetic analyses using a variety of species, including avians, rodents, zebrafish, and humans. These fundamental studies have contributed not only a detailed appreciation of the complexities of ENS development, but are now also yielding novel opportunities to develop cell-based therapies for treating enteric neuropathies. Researchers studying ENS development gathered in New York in 2006 for their first international symposium. This triennial meeting was subsequently held in London (2009), Hong Kong (2012), and Rotterdam (2015). The symposium brings together clinicians and researchers, including developmental and cell biologists, pathologists, geneticists, physiologists, pediatric gastroenterologists and surgeons, and stem cell researchers, who all share a common interest in the development and pathophysiology of the enteric nervous system and the diagnosis and treatment of neurointestinal diseases. All of the Symposia have been very successful, each hosting approximately 150 participants from 20 different countries from around the world. The 5th International Symposium on “Development of the Enteric Nervous System: Cells, Signals, Genes and Therapy” will be held in Boston in April, 2018. This will be the first meeting focused on ENS development to be held in the U.S. in 12 years and builds on the success of the prior meetings and the growing importance of ENS research. The specific aims of this R13 application are as follows: (1) To encourage the participation of young investigators, particularly women and minorities under-represented in science, at this 5th International Symposium by offering 10 Travel Awards to offset registration costs and travel expenses; and (2) To enhance the likelihood of long-term success for young investigators pursuing academic careers by establishing mentored relationships with select faculty and members of the meeting’s Organizing Committee. It is our expectation that this meeting will help to build lasting mentorship and collaborations that will help to advance the career development of the Travel Award recipients.

项目摘要/摘要 在过去的20年里，我们对肠道神经系统的了解取得了显著的进步。 (ENS)以及因发育异常或其他原因引起的先天性和获得性神经肠病 ENS的维护。在理解ENS发育方面的许多进展都是由细胞取得的， 利用包括鸟类在内的各种物种进行的分子生物学、发育生物学研究和遗传分析， 啮齿动物、斑马鱼和人类。这些基础性研究不仅有助于对 ENS发展的复杂性，但现在也产生了开发基于细胞的新机会 肠道神经病的治疗方法。 研究ENS发展的研究人员于2006年聚集在纽约，参加他们的第一次国际研讨会。 三年一度的会议随后在伦敦(2009年)、香港(2012年)和鹿特丹(2015年)举行。这个 研讨会汇集了临床医生和研究人员，包括发育和细胞生物学家、病理学家、 遗传学家，生理学家，儿科胃肠病专家和外科医生，以及干细胞研究人员，他们都分享 对肠道神经系统的发育、病理生理学和诊断的共同兴趣 以及神经肠道疾病的治疗。所有的研讨会都非常成功，每一次都主办 来自世界各地20个不同国家的约150名与会者。第五届国际 “肠道神经系统的发展：细胞、信号、基因和治疗”研讨会将举行 2018年4月在波士顿。这将是12年后在美国举行的第一次关注ENS发展的会议 在前几次会议取得成功的基础上，以及欧洲经委会研究日益重要的情况下，这项工作取得了重大进展。 这项R13申请的具体目的如下：(1)鼓励青年调查人员参与， 特别是在科学界代表性不足的妇女和少数群体，在这次第五届国际研讨会上提供了 10个旅行大奖，以抵销登记费用和旅行费用；及(2)增加长期 通过与SELECT建立指导关系，年轻研究人员追求学术生涯的成功 会议组委会的教职员工和成员。我们期望这次会议将有助于 建立持久的指导和合作关系，这将有助于推动旅行奖的职业发展 收件人。