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Development of the Enteric Nervous System: Cells, Signals, Genes, and Therapy

肠神经系统的发育：细胞、信号、基因和治疗

基本信息

批准号：
9541099
负责人：
ALLAN M GOLDSTEIN
金额：
$ 1.96万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-15 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9541099
关键词：
Area Attention Award Birds Boston Cell Therapy Cells Cellular biology Childhood Collaborations Congenital Megacolon Country Development Developmental Biology Diagnosis Disease Distal Enteral Enteric Nervous System Event Faculty Fostering Functional disorder Future Gastroenterologist Goals Grant Growth Hong Kong Human International Intestines Knowledge Lead London Maintenance Mentors Mentorship Molecular Biology Morbidity - disease rate Neuropathy New York Participant Pathologist Productivity Research Personnel Rodent Science Scientist Signal Transduction Stem cells Structure Surgeon Time Travel Underrepresented Minority Woman Zebrafish base career career development cost design expectation gene therapy genetic analysis interest meetings member nervous system development novel public health relevance senior faculty success symposium systems research

项目摘要

Project Summary/Abstract Over the past 20 years, remarkable progress has been made in our understanding of the enteric nervous system (ENS) and of the congenital and acquired neurointestinal diseases that result from abnormal development or maintenance of the ENS. Many of the advances in understanding ENS development have been made by cell, molecular, and developmental biology studies and genetic analyses using a variety of species, including avians, rodents, zebrafish, and humans. These fundamental studies have contributed not only a detailed appreciation of the complexities of ENS development, but are now also yielding novel opportunities to develop cell-based therapies for treating enteric neuropathies. Researchers studying ENS development gathered in New York in 2006 for their first international symposium. This triennial meeting was subsequently held in London (2009), Hong Kong (2012), and Rotterdam (2015). The symposium brings together clinicians and researchers, including developmental and cell biologists, pathologists, geneticists, physiologists, pediatric gastroenterologists and surgeons, and stem cell researchers, who all share a common interest in the development and pathophysiology of the enteric nervous system and the diagnosis and treatment of neurointestinal diseases. All of the Symposia have been very successful, each hosting approximately 150 participants from 20 different countries from around the world. The 5th International Symposium on “Development of the Enteric Nervous System: Cells, Signals, Genes and Therapy” will be held in Boston in April, 2018. This will be the first meeting focused on ENS development to be held in the U.S. in 12 years and builds on the success of the prior meetings and the growing importance of ENS research. The specific aims of this R13 application are as follows: (1) To encourage the participation of young investigators, particularly women and minorities under-represented in science, at this 5th International Symposium by offering 10 Travel Awards to offset registration costs and travel expenses; and (2) To enhance the likelihood of long-term success for young investigators pursuing academic careers by establishing mentored relationships with select faculty and members of the meeting’s Organizing Committee. It is our expectation that this meeting will help to build lasting mentorship and collaborations that will help to advance the career development of the Travel Award recipients.

项目总结/文摘