In vivo mapping of human brainstem vestibular and autonomic pathways

人脑干前庭和自主神经通路的体内绘图

• 批准号: 9509424
• 负责人: Marta Bianciardi
• 金额: $ 21.38万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9509424
• 关键词: Acute; Agreement; Anatomy; Animal Model; Animals; Anxiety; Arousal; Atlases; Autonomic Pathways; Behavior; Benchmarking; Brain Stem; Brain imaging; Cell Nucleus; Chronic; Clinical; Clinical Research; Complex; Data; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Dizziness; Echo-Planar Imaging; Event; Foundations; Functional Imaging; Future; Goals; Gold; Human; Hypersensitivity; Image; Imaging technology; Incidence; Intervention; Knowledge; Label; Lateral; Link; Magnetic Resonance Imaging; Manuals; Maps; Measures; Medial; Methods; Modeling; Motion; Motor; Nucleus solitarius; Pathologic; Pathologic Processes; Pathway interactions; Physiological; Predisposition; Prevention; Process; Public Health; Publishing; Recovery; Research; Resolution; Rest; Stimulus; Structure; Symptoms; System; Technology; Testing; Translating; Treatment outcome; Vestibular nucleus structure; Work; base; connectome; contrast imaging; imaging modality; improved; in vivo; in vivo evaluation; midbrain central gray substance; neural circuit; neuroimaging; novel; parabrachial nucleus; prospective; tool; vestibular pathway; vestibulo-ocular reflex

PROJECT SUMMARY/ABSTRACT For decades, research on recovery from acute vestibular deficits has focused on compensatory mechanisms in the brainstem vestibular nuclei and associated brainstem/cerebellar pathways. In contrast, recent prospective clinical studies identified elevated autonomic arousal and anxiety as the primary predictors of failed recovery and prolonged vestibular symptoms (e.g. dizziness, imbalance, hypersensitivity to motion stimuli) in chronic vestibular disorders following acute vestibular events. Thus, adverse vestibular-autonomic interactions appear to precipitate and perpetuate chronic vestibular disorders. Pathways linking vestibular nuclei to the amygdalae via parabrachial and associated brainstem autonomic nuclei are thought to underlie these disorders. Greater knowledge of vestibular-autonomic interactions, when translated into early clinical interventions, promises to maximize recovery from acute vestibular disorders, an important public health goal, by reducing the incidence of chronic vestibular disorders and improving their treatment. Progress is hampered by a critical barrier: neural circuitry of brainstem vestibular-autonomic processes is underspecified in living humans, despite extensive research in animal models. Existing in vivo brain imaging methods lack sufficient sensitivity and contrast to localize key brainstem vestibular and autonomic nuclei, such as the vestibular nuclei complex, periaqueductal gray, raphe magnus, lateral and medial parabrachial nuclei, and solitary nucleus. To surmount this barrier, the central aim of the proposed research is to generate in living healthy subjects an original probabilistic neuroimaging atlas of vestibular and autonomic nuclei in standard stereotaxic space and to map their benchmark connectivity diagram (“connectome”) at rest and during vestibular stimulation using advanced imaging technology (7 T and 3 T Connectome scanners). This proposal builds on our recently published 7 T work in living humans, which yielded the probabilistic atlas and connectome of two An (periaqueductal gray, raphe magnus) and nine other brainstem nuclei of the arousal and motor systems. We propose to extend this atlas and connectome to include the vestibular nuclei complex and three additional autonomic nuclei (lateral and medial parabrachial nuclei, and solitary nucleus), as well as to use vestibular stimulation to pioneeringly test hypothesis driven functional connectivity changes in brainstem vestibular and autonomic nuclei. Thus, our project will provide two important new tools, a structural atlas and connectome for studying the vestibular nuclei, multiple autonomic nuclei, and their interactions in living humans. The ability of localizing vestibular and autonomic nuclei in neuroimages and of investigating vestibular-autonomic pathways in living humans will enhance our understanding of how brainstem vestibular-autonomic processes relate to the patho- physiologic mechanism causing chronic vestibular disorders and to their treatment outcomes.

项目摘要/摘要 几十年来，从急性前庭定义恢复的研究一直集中在补偿性上 脑干前庭核和相关的脑干/小脑途径的机制。相比之下， 最近的前瞻性临床研究确定自主神经和动画为主要预测因子 恢复失败和长时间的前庭症状（例如头晕，失衡，超敏反应 刺激）急性前庭事件后的慢性前庭疾病。那是不利的前庭自治 相互作用似乎沉淀并永久存在慢性前庭疾病。连接前庭的途径 通过副型和相关的脑干自动核核向杏仁核的核被认为是基础 这些疾病。当翻译成早期临床时，对前庭自治相互作用的了解更大 干预措施，有望最大化急性前庭疾病的恢复，这是一个重要的公共卫生目标， 通过减少慢性前庭疾病的发生率并改善治疗。进度受到阻碍 通过关键障碍：脑干前庭自治过程的神经回路被指定 人类，渴望在动物模型中进行广泛的研究。现有的体内脑成像方法缺乏足够的 敏感性和与位置关键的脑干前庭和自主核的对比，例如前庭核 复合物灰色，raphe Magnus，侧面和培养基核心核和固体核。 为了克服这一障碍，拟议的研究的核心目的是在健康的受试者中产生 标准立体定位空间中前庭和自主核的原始概率神经影像学地图 在休息和前庭刺激期间绘制其基准连接图（“ connectome”） 高级成像技术（7 T和3 T Connectome扫描仪）。该提议建立在我们最近的 发表了7 t在活人中的作品，产生了概率的地图集和两个 （PeriaqueDuctal Gray，Raphe Magnus）和唤醒和运动系统的其他九个脑干核。我们 提议扩展此图集和连接组以包括前庭核复合体和另外三个 自主神经（外侧和内侧副核和固体核），以及使用前庭 刺激以开创性检验假设驱动的功能连通性变化，脑干前庭和 自主核。 这是我们的项目将提供两个重要的新工具，一个结构地图集和连接组，用于研究 前庭核，多个自主核及其在活人中的相互作用。本地化的能力 神经图像中的前庭和自主核研究和研究前庭自主途径 人类将增强我们对脑干的前庭自治过程与病情的关系 生理机制引起慢性前庭疾病及其治疗结果。