Continuation of Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS), Biostatistics Research Center

摘要 本申请要求续签目前支持生物统计学研究的拨款 青少年实验室(TL)联盟的中心(BRC)。这种多中心、前瞻性、观察性的 一项旨在评估242名连续招募的减肥手术的风险和好处的研究 在参与的五个临床中心接受减肥手术的青少年。到年底的时候 目前的资助期(2016年8月)，大多数研究对象将完成5年 后续行动。随着资金的更新，BRC继续领导数据收集和管理 以及TL财团的统计分析业务。资金的续期将提供 收集和检查Roux-en-Y胃分流术和套管术的长期结果的机会 胃切除术，当今最常用的手术。收集额外的纵向 从第6年到第10年的措施将重要地记录减肥的持久性、合并症 解决方案、生活质量、微量营养素状况，并将确定长期不良事件。 继续收集生物标本将继续推动调查人员利用 辅助性研究机制。增加新的测量方法来研究骨骼健康，认知 功能和行为模式将进一步提升延伸研究的价值。

Abstract This application requests renewal of the current grant supporting the Biostatistics Research Center (BRC) for the Teen-LABS (TL) consortium. This multicenter, prospective, observational study seeks to evaluate the risks and benefits of bariatric surgery in 242 consecutively recruited adolescents undergoing bariatric surgery at the participating five clinical centers. By the end of the current funding period (August 2016), most study subjects will have completed 5 years of follow-up. With a funding renewal, the BRC continue to lead the data collection and management and statistical analysis operations for the TL consortium. A renewal of funding will provide an opportunity to collect and examine long-term outcomes of Roux-en-Y gastric bypass and sleeve gastrectomy, the most commonly used operations today. Collection of additional longitudinal measures from years 6 to10 will importantly document durability of weight loss, comorbidity resolution, quality of life, micronutrient status, and will identify long-term adverse events. Continued collection of biospecimens will continue to drive new discovery by investigators utilizing the ancillary studies mechanism. Addition of new measures to study bone health, cognitive function, and behavioral patterns will further enhance the value of an extension of the study.