2021 Natural Products & Bioactive Compounds Gordon Research Conference & Gordon Research Seminar

项目摘要 天然产品一直是药物发现和药物开发的灵感来源。他们的 独特多样的分子支架促进了对生物合成途径、分子 目标，并启发了新的合成战略，这使得它们在结构上得到确认和准备。 总体而言，这些努力推动了该领域的发展，并使寻找下一代药物成为可能 未被治疗的人类疾病，如耐多药细菌感染、癌症和其他罕见的基因 疾病。因此，毫不奇怪，大约三分之二的上市药物具有天然的 产品来源。2021年会议的总体目标是延续以杰出的 在科学前沿的演讲和讨论，以进一步推动广泛和不断的 不断演变的天然产品领域。一个独特而多样的科学家小组将在这段时间内聚集在一起 科学学科，来自不同的经验水平、背景和人口统计。另外， 将鼓励和促进与会者之间的协作和跨学科互动，同时还 纳入了新兴科学家的发展。大约30个演讲式的演讲将 突出未发表的研究，激发严谨的讨论。互补性非正式研究 讨论通常是75次，将通过互动海报会议在轻松的社交环境中进行。此外， 会议形式为专业发展和社会互动提供了重要机会 在与会者之间。因此，这个R13应用程序的目标是为Gordon申请部分资金 研究会议(08/01/21-08/06/21)及相关高顿研究研讨会(07/31/21-08/01/21) 安多佛市普罗科特学院招收毕业生的天然产物和生物活性物质研究 学生、博士后、早期职业科学家、女性和其他未被充分代表的少数群体 高质量的科学会议。会议将由经常出席的Amber J.Onorato博士主持 北肯塔基大学化学和生物化学系副教授。这个 副主席将由执行董事兼药物化学领导小组组长菲利普·R·凯姆担任 AbbVie，由前任主席提名，并由2019年GRC与会者选举(07/28/19- 08/02/19)。

Project Summary Natural products have consistently served as an inspiration for drug discovery and drug development. Their unique and diverse molecular scaffolds have stimulated investigation of biosynthetic pathways, molecular targets, and inspired new synthetic strategies, which allowed for their structural confirmation and preparation. Collectively, these efforts have advanced the field and enabled the search for the next generation of drugs for unmet human diseases such as multidrug resistant bacterial infections, cancers, and other rare genetic diseases. Therefore, not surprisingly, approximately two-thirds of all marketed pharmaceuticals have natural product origins. The overall objective of the 2021 meeting is to continue the tradition of featuring exceptional presentations and discussions at the forefront of science in order to further advance the broad and constantly evolving field of natural products. A unique and diverse group of scientists will be assembled that span scientific disciplines, and stem from various experience levels, backgrounds, and demographics. Also, collaborative and cross-disciplinary interactions among attendees will be encouraged and fostered, while also incorporating the development of emerging scientists. Approximately, 30 lecture-style presentations will highlight unpublished research and stimulate rigorious discussion. Complementary informal research discussions, typically 75, will occur via interactive poster sessions in a relaxed, social setting. In addition, the conference format provides significant opportunity for professional development and social interactions between attendees. Therefore, the goal of this R13 application is to request partial funding for the Gordon Research Conference (08/01/21 – 08/06/21) and associated Gordon Research Seminar (07/31/21 – 08/01/21) on Natural Products and Bioactive Compounds at Proctor Academy in Andover, NH in order to recruit graduate students, postdocs, early career scientists, women, and other underrepresented minorities to an excellent and high quality scientific conference. The meeting will be chaired by Dr. Amber J. Onorato, a frequent attendee and associate professor in the department of chemistry and biochemistry at Northern Kentucky University. The vice-Chair will be Philip R. Kym, Executive Director and Head of the Medicinal Chemistry Leadership Team at AbbVie, who was nominated by previous chairs and elected by conferees at the 2019 GRC (07/28/19 – 08/02/19).