Effects of Acute Exercise on Functional Magnetic Resonance Spectroscopy Measures of GABA in Aging and Chronic Stroke

目前的建议旨在指数急性有氧运动对兴奋和抑制平衡的影响， 磁共振波谱（MRS）在老龄化和慢性中风。有重复的证据表明 剧烈的有氧运动会在两小时内增加感觉运动γ-氨基丁酸（GABA） 期我们的实验室有技术能力在两个疗程之间可靠地测量GABA， 开发了一种运动学习的功能性测量方法，该方法改变了老年人的GABA，称为功能性MRS（fMRS）。 急性运动引起的SM GABA的局灶性增加为检验衰老相关的假设提供了机会。 运动学习的减少可能与SM GABA水平降低有关。也就是说，GABA水平可能需要增加 在选择性释放SM GABA之前将其调节至特定水平可以提供改善的长时程增强。这可以 使用横截面方法进行评估。然而，到目前为止，我们还没有采用急性运动模型 本研究将评估这种方法的可行性。此外，由于意图 我们的研究计划的一部分是将衰老相关的发现转化为中风运动康复，我们将利用这一点， SPiRE直接研究慢性上肢损伤的卒中患者。根据早期的发现， 作为目前的优秀奖，我们现在寻求在慢性卒中幸存者的SM中试行MRS措施，以测量变化 在一次剧烈运动后的GABA水平。为了实现这些目标，我们将招募30名参与者， 测试急性有氧运动是否可以对SM GABA水平产生直接调节作用，因为这些与 运动学习由于这些目标涉及评估两个人群（老龄化）的新干预措施的可行性， 退伍军人和慢性中风患者），我们相信这对运动康复有很大的影响。

The current proposal seeks to index the effect of acute aerobic exercise on excitatory and inhibitory balance using magnetic resonance spectroscopy (MRS) in aging and in chronic stroke. There exists replicated evidence that acute bouts of aerobic exercise increase sensorimotor gamma-aminobutyric acid (GABA) within a two-hour period. Our lab has the technical capability to reliably measure GABA between two sessions and we have developed a functional measure of motor learning that alters GABA in older adults called functional MRS (fMRS). Focal increases in SM GABA due to acute exercise offers the opportunity to test the hypothesis that aging related decreases in motor learning may be related to lower levels of SM GABA. That is, GABA levels may need to increase to a specific level before selective release of SM GABA can afford improved long-term potentiation. This can be evaluated using a cross-sectional approach. However, to date, we have not employed an acute exercise model within our lab for functional MRS. This study will evaluate the feasibility of this approach. Further, as the intent of our research program is to translate aging-related findings to stroke motor rehabilitation, we will use this SPiRE to directly study stroke patients with chronic upper extremity impairment. In light of early findings from a current Merit Award, we now seek to pilot MRS measures in SM in chronic stroke survivors to measure changes in GABA after a bout of acute exercise. To achieve these goals, we will enroll 30 participants in cross-section to test if acute aerobic exercise can have immediate modulatory effects on levels of SM GABA as these relate to motor learning. As these aims involve evaluating the feasibility of a new intervention with two populations (aging Veterans and those with chronic stroke), we believe this offers high impact for motor rehabilitation.