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Contextual Representation of Tactile Information in Mouse Primary Somatosensory Cortex

小鼠初级体感皮层触觉信息的上下文表征

基本信息

批准号：
10308417
负责人：
Alan Joseph Emanuel
金额：
$ 9.91万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-01 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10308417
关键词：
Address Afferent Neurons Animal Behavior Animals Area Behavior Behavior monitoring Behavioral Brain Chronic Communities Complex Computer Models Computer Vision Systems Custom Cutaneous Detection Development Development Plans Discrimination Electrophysiology (science)Environment Felis catus Genetic Goals Inherited International Joints Knowledge Laboratories Learning Manuscripts Mechanoreceptors Mediating Methods Modeling Modernization Movement Mus Neuraxis Neurobiology Neurons Organism Patients Perception Performance Peripheral Peripheral Nervous System Positioning Attribute Postdoctoral Fellow Primates Process Property Publications Quality of life Research Research Personnel Resources Rewards Role Sensory Signal Transduction Skin Somatosensory Cortex Speed Spinal Cord Stimulus Structure System Tactile Testing Thalamic structure Touch sensation Training Work awake brain machine interface career career development disability experimental study flexibility genetic approach genetic manipulation in vivo insight loss of function mutation mechanical device medical schools meetings mouse genetics nervous system disorder neural circuit novel optogenetics prevent recruit relating to nervous system response responsible research conduct sensory system somatosensory

项目摘要

Career Plan and Environment of Career Development: Dr. Emanuel is a joint postdoctoral fellow in the laboratories of Drs. David Ginty and Chris Harvey who is dedicated to a career as an academic researcher. Drs. Emanuel, Ginty, and Harvey have developed a 12-point career development plan that will enable Dr. Emanuel's transition to an independent research position. This plan incorporates resources available at Harvard Medical School, including formal and informal training from the community within the Department of Neurobiology and the broader Harvard Medical School community. Formal training includes attendance at seminars on professional development and responsible conduct of research as well as engaging the wider scientific community with publication of manuscripts describing Dr. Emanuel's work and presentations at international meetings. Overall, this plan will optimally prepare Dr. Emanuel for the transition to an independent career. Research Plan: The goal of this project is to determine how the representation of complex features in primary somatosensory cortex are produced by cortical and subcortical neural circuitry and how these representations are adapted for the behavior of the animal. Specifically, the experiments in this proposal will use mouse genetic approaches and in vivo electrophysiology to address the neural underpinnings of speed, direction, and orientation tuning in primary somatosensory cortex (Aim 1). Combining in vivo electrophysiology with genetic manipulations and recording from primary somatosensory cortex will determine the extent to which these cortical representations are necessary for and adapt to performance of tactile behaviors (Aim 2). Finally, combining in vivo electrophysiology in freely moving animals with modern computer vision for monitoring behavior and the force applied to the skin will determine how neurons in primary somatosensory cortex are engaged during natural movements and environmental interactions (Aim 3). In all, these experiments will yield insight into the fundamental processes underlying sensory processing in the central nervous system.

职业规划和职业发展环境：伊曼纽尔博士是大卫·金蒂博士和克里斯·哈维博士实验室的联合博士后研究员，致力于学术研究。伊曼纽尔博士、金蒂博士和哈维博士制定了12点职业发展计划，这将使伊曼纽尔博士能够过渡到一个独立的研究职位。该计划纳入了哈佛医学院可用的资源，包括来自神经生物学系社区和更广泛的哈佛医学院社区的正式和非正式培训。正式培训包括参加关于专业发展和负责任地开展研究的研讨会，以及通过出版介绍伊曼纽尔博士工作的手稿和在国际会议上的发言，使更广泛的科学界参与进来。总体而言，这项计划将为伊曼纽尔博士向独立职业生涯的过渡做好最佳准备。研究计划：该项目的目标是确定初级躯体感觉皮质中复杂特征的表征是如何由皮质和皮质下神经回路产生的，以及这些表征如何适应动物的行为。具体地说，这项提案中的实验将使用小鼠遗传方法和体内电生理学来解决初级躯体感觉皮质中速度、方向和方向调整的神经基础(目标1)。将体内电生理学与遗传操作相结合，并从初级躯体感觉皮质进行记录，将确定这些皮质表征在多大程度上是触觉行为表现所必需和适应的(目标2)。最后，将自由运动动物体内的电生理学与用于监测行为和施加在皮肤上的力的现代计算机视觉相结合，将确定初级躯体感觉皮质中的神经元在自然运动和环境相互作用期间是如何进行的(目标3)。总而言之，这些实验将深入了解中枢神经系统中潜在的感觉处理的基本过程。