Does Adding a Tailored Cognitive Behavioral Therapy (CBT) Mobile Skills App Mediate Higher Rates of Depression Recovery, Adjustment, and Quality of Life in OEF/OIF Veterans Compared to Standard CBT?

与标准 CBT 相比，添加定制认知行为治疗 (CBT) 移动技能应用程序是否可以提高 OEF/OIF 退伍军人的抑郁恢复率、调整率和生活质量？

• 批准号: 10311118
• 负责人: Judith Ann Callan
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311118
• 关键词: Acute; Address; Affect; Aftercare; Anger; Anxiety; Certification; Cognitive Therapy; Depressed mood; Disease; Disease remission; Effectiveness; Freedom; Generations; Health Status; Healthcare; Home; Hospitals; Improve Access; Individual; Information Technology; Intervention; Life Style; Long-Term Effects; Measures; Mediating; Mental Depression; Mental disorders; Methods; Paper; Participant; Patients; Personal Satisfaction; Phase; Post-Traumatic Stress Disorders; Procedures; Psychotherapy; Quality of life; Randomized; Randomized Clinical Trials; Recovery; Reporting; Service delivery model; Site; System; Time; Training; Veterans; Work; cognitive benefits; comorbidity; depressive symptoms; evidence base; experimental arm; improved; innovation; mobile application; operation; population health; prevent; psychologic; skill acquisition; skills; skills training; smartphone Application; tool; treatment comparison

Cognitive Behavioral Therapy (CBT) is the leading evidence-based psychotherapy for depression, which affects 18.5% of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans (hereafter referred to as OEF/OIF). Yet, OEF/OIF Veterans had only a 30% average reduction in mean depression scores from the initial to later phase of treatment. This was true despite the rigorous training and certification procedures for VA CBT-D. Improving the rate of depression recovery and remission is vital to enhance OEF/OIF Veteran’s ability to improve work and home adjustment and overall quality of life. Broad access to all key ingredients of CBT, including skills practice (homework), is associated with improved and faster recovery from depression. OEF/OIF Veterans and patients with depression have reported many barriers (i.e., time, chaotic lifestyles, and low energy) to following through with their skills practice assignments. In the absence of targeted strategies/interventions to address the barriers that prevent CBT skills practice, OEF/OIF Veterans will remain unable to reap the full benefits/effects of CBT. With specific tailored interventions to address this gap in treatment, OEF/OIF Veterans will improve rates of recovery from depression, diminished home and work adjustment, and poor quality of life. Leveraging the technological savvy of this generation of Veterans to improve access to CBT skills practice is a logical tactic to address this gap in treatment. Smartphone apps have been identified as a useful widely-used tool to improve the effectiveness of psychological treatments. There is, however, a paucity of empirical studies on the use of mobile apps in the treatment of depressed OEF/OIF Veterans and in psychological treatment overall. The promising pilot results of a comprehensive tailored smartphone app for CBT skills practice for OEF/OIF Veterans (“CBT MobileWork-V”), leads us to propose a larger-scale randomized clinical trial (RCT) to measure the efficacy of CBT enhanced with CBTMobileWork-V (the experimental arm) for improving CBT understanding and skill acquisition and depressive symptoms, in OEF/OIF Veterans with depression compared to standard CBT-D. Specifically, over a 27-month period we propose to randomize 268 eligible OEF/OIF Veterans with depressive symptoms, to either CBT augmented with the comprehensive CBT skill training smartphone app CBT MobileWork-V or standard CBT-D with traditional skills practice methods (i.e., paper and pencil). The Specific Aims of this study are: Primary Aim 1) To assess whether CBT-D augmented with CBT MobileWork-V (hereafter referred to as CBT- D+) promotes greater CBT understanding and skill acquisition compared to traditional CBT-D. Primary Aim 2a) To examine the short-term effect in depressive symptoms after 12 weeks of CBT-D+ versus standard CBT-D. Primary Aim 2b) To examine the long-term effect in depressive symptoms at 6 months post treatment of the CBT-D+ intervention versus traditional CBT-D.

认知行为疗法（CBT）是治疗抑郁症的领先循证心理疗法， 影响了18.5%的持久自由行动（OEF）、伊拉克自由行动（OIF）和新行动（Operation New） 黎明（OND）退伍军人（以下简称OEF/OIF）。然而，OEF/OIF退伍军人平均只有30% 从治疗初期到后期平均抑郁评分降低。这是真的，尽管 VA CBT-D的严格培训和认证程序。提高抑郁症的康复率， 缓解对于提高OEF/OIF退伍军人改善工作和家庭调整的能力至关重要， 生活质量 广泛获得CBT的所有关键成分，包括技能练习（家庭作业），与以下因素有关： 改善和更快地从抑郁症中恢复。OEF/OIF退伍军人和抑郁症患者报告说， 许多屏障（即，时间，混乱的生活方式和低能量）来完成他们的技能练习 分配任务。在缺乏有针对性的战略/干预措施来解决阻碍CBT技能的障碍的情况下， 实践中，OEF/OIF退伍军人将仍然无法获得CBT的全部好处/效果。特别定制的 通过采取干预措施，解决治疗方面的这一差距，OEF/OIF退伍军人将提高从 抑郁症、家庭和工作适应能力下降以及生活质量差。 利用这一代退伍军人的技术悟性来提高获得CBT技能的机会 实践是解决这一治疗差距的合理策略。智能手机应用程序已被确定为有用的 广泛使用的工具，以提高心理治疗的有效性。然而， 关于使用移动的应用程序治疗抑郁的OEF/OIF退伍军人和 整体心理治疗。一个全面的量身定制的智能手机应用程序， OEF/OIF退伍军人的CBT技能实践（“CBT MobileWork-V”），使我们提出了一个更大规模的 随机临床试验（RCT），以衡量CBT MobileWork-V增强CBT的疗效（ 实验组）用于改善CBT理解和技能获得以及抑郁症状， OEF/OIF退伍军人抑郁症与标准CBT-D相比。具体来说，在27个月的时间里， 我建议将268名有抑郁症状的合格OEF/OIF退伍军人随机分为两组， 使用全面的CBT技能培训智能手机应用程序CBT MobileWork-V或标准CBT-D， 传统的技能练习方法（即，纸和铅笔）。本研究的具体目的是： 主要目的1）评估使用CBT MobileWork-V（以下简称CBT-V）增强的CBT-D是否 D+）与传统的CBT-D相比，促进了更好的CBT理解和技能获取。 主要目的2a）检查CBT-D+与对照组12周后抑郁症状的短期效果。 标准CBT-D 主要目的2b）检查治疗后6个月时抑郁症状的长期效果。 CBT-D+干预与传统CBT-D。