Fibrin(ogen) control of metabolic inflammation and obesity

纤维蛋白（原）控制代谢炎症和肥胖

• 批准号: 10311076
• 负责人: MATTHEW J FLICK
• 金额: $ 37.16万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-20 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311076
• 关键词: Fibrin; ogen; control; metabolic; inflammation

项目成果

Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state.

• DOI: 10.1038/s44161-021-00006-4
• 发表时间: 2022-01
• 期刊: NATURE CARDIOVASCULAR RESEARCH
• 作者: Hernandez, Gloria E;Ma, Feiyang;Martinez, Guadalupe;Firozabadi, Nadia B;Salvador, Jocelynda;Juang, Lih Jiin;Leung, Jerry;Zhao, Peng;Lopez, Diego A;Ardehali, Reza;Beaudin, Anna E;Kastrup, Christian J;Pellegrini, Matteo;Flick, Matthew J;Iruela-Arispe, M Luisa
• 通讯作者: Iruela-Arispe, M Luisa

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain.

• DOI: 10.1038/s41467-021-23084-1
• 发表时间: 2021-05-18
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Chan CC;Harley ITW;Pfluger PT;Trompette A;Stankiewicz TE;Allen JL;Moreno-Fernandez ME;Damen MSMA;Oates JR;Alarcon PC;Doll JR;Flick MJ;Flick LM;Sanchez-Gurmaches J;Mukherjee R;Karns R;Helmrath M;Inge TH;Weisberg SP;Pamp SJ;Relman DA;Seeley RJ;Tschöp MH;Karp CL;Divanovic S
• 通讯作者: Divanovic S

Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γΔ5 mice drives acute liver injury.

突变型纤维蛋白原-γδ5 小鼠中纤维蛋白原γ链交联的改变会导致急性肝损伤。

• DOI: 10.1016/j.jtha.2023.04.003
• 发表时间: 2023
• 期刊: Journal of thrombosis and haemostasis : JTH
• 作者: Poole,LaurenG;Schmitt,LaurenR;Schulte,Anthony;Groeneveld,DafnaJ;Cline,HollyM;Sang,Yaqiu;Hur,WoosukS;Wolberg,AlisaS;Flick,MatthewJ;Hansen,KirkC;Luyendyk,JamesP
• 通讯作者: Luyendyk,JamesP

Fibrinogen γ' promotes host survival during Staphylococcus aureus septicemia in mice.

• DOI: 10.1016/j.jtha.2023.03.019
• 发表时间: 2023-08
• 期刊: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
• 影响因子: 10.4
• 作者: Negron, Oscar;Weggeman, Miranda;Grimbergen, Jos;Clark, Emily G.;Abrahams, Sara;Hur, Woosuk S.;Koopman, Jaap;Flick, Matthew J.
• 通讯作者: Flick, Matthew J.

Cross-linking by tissue transglutaminase-2 alters fibrinogen-directed macrophage proinflammatory activity.

• DOI: 10.1111/jth.15670
• 发表时间: 2022-05
• 期刊: Journal of thrombosis and haemostasis : JTH