2022 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference and Seminar

总结 部分支持是要求研究生和博士后研究员，初级和中级职业教师 参加戈登研究研讨会和会议（GRS/GRC）题为“纤溶酶原激活 和细胞外蛋白水解”，将分别于2022年2月5日至6日和6日至11日在加利福尼亚州文图拉举行。 这将是第18届GRC，因为该会议自1990年以来每两年连续举行一次。的 2022年GRC的重点将是细胞外蛋白水解酶的机制和治疗靶点， 包括纤溶酶（原）、纤溶酶原激活剂、凝血蛋白酶、基质金属蛋白酶（MMP）， 它们的前体、抑制剂和效应物。最近的数据表明，蛋白酶在循环中的表达 并且组织的血管外隔室与许多病理过程相关。我们的邀请 发言人和讨论领导人将介绍他们最近和新出现的工作， 科学和临床主题，包括心血管疾病，衰老，脑血管功能，代谢 疾病、肌肉骨骼和神经退行性疾病、癌症、感染和免疫、组织重塑 和再生，以及创伤。重点将放在强调这些蛋白质的作用， 疾病修饰剂以及使用或靶向这些因子用于诊断和治疗的效用。之一 2022年GRC会议的主要目标是将基础研究转化为临床。与会者将 通过邀请和在线提交的申请选择。他们将被选中代表一个多样化的 一系列研究，特别强调机会平等和所有人的包容性 人口统计学将作出更多努力，招聘代表性不足的妇女和科学家。 小组作为会议的领导者和发言者为GRS和GRC。其实，这是一种力量。 会议将是该领域的年轻科学家与讨论领导人的互动和联网 和扬声器。相关的GRS，这是会议的一个年轻的功能，将提供一个独特的 培训生和新科学家展示他们的研究和分享GRC经验的机会。这 为期两天的研讨会将由研究生和博士后研究员与领导的支持下组织 研究人员和GRC椅子，并将允许纤溶酶原激活领域的初级研究人员 和细胞外蛋白水解走到一起，讨论他们目前未发表的研究，同时建立 他们与同行的非正式网络，可能会导致一生的合作和科学成就。

Summary Partial support is requested for graduate students and post-doctoral fellows, and junior and midcareer faculty to participate in the Gordon Research Seminar and Conference (GRS/GRC) entitled “Plasminogen Activation and Extracellular proteolysis”, which will be held in Ventura, CA on February 5-6 and 6-11, 2022, respectively. This will be the 18th GRC, as the conference has been held continuously every two years since 1990. The focus of the 2022 GRC will be on mechanisms and therapeutic targets of extracellular proteolytic enzymes, including plasmin(ogen), plasminogen activators, coagulation proteases, matrix-metalloproteinases (MMPs), their precursors, inhibitors, and effectors. Recent data suggest that the expression of proteases in circulation and the extravascular compartments of tissues is tied to numerous pathological processes. Our invited speakers and discussion leaders will present their recent and emerging work across a spectrum of basic science and clinical topics, including cardiovascular disease, aging, cerebrovascular function, metabolic diseases, musculoskeletal and neurodegenerative diseases, cancer, infection and immunity, tissue remodeling and regeneration, as well as trauma. Priority will be placed on highlighting both the role these proteins play as disease modifiers as well the utility of employing or targeting these factors for diagnosis and therapy. One of the major goals for the 2022 GRC meeting is translating basic research into the clinic. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of research, with a strong emphasis on equity of opportunity and inclusion of individuals across all demographic metrics. Additional efforts will be committed to recruit women and scientists of underrepresented groups as session leaders and speakers for both the GRS and GRC. Indeed, an intended strength of this meeting will be the interaction and networking of the young scientists in the field, with the discussion leaders and the speakers. The associated GRS, which is a younger feature of the conference, will provide a unique opportunity for trainees and beginning scientists to present their research and share the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers and the GRC Chairs, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current unpublished research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.