Structural biology of bacterial outer membrane proteins (overall information: 411-445, 456-458) (446)

细菌外膜蛋白的结构生物学（总体信息：411-445、456-458）（446）

• 批准号: 9477717
• 负责人: SUSAN K. BUCHANAN
• 金额: $ 31.45万
• 依托单位: NEW YORK STRUCTURAL BIOLOGY CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9477717
• 关键词: Bacterial Outer Membrane Proteins; Biological; Development; Feedback; Goals; Membrane Proteins; Methodology; Problem Solving; Production; Research; Research Personnel; Resources; Secure; Technology; Testing; driving force; structural biology; technology development

The Center on Membrane Protein Production and Analysis (COMPPÅ) has chosen 15 DBPs, which will provide a driving force for each of the TR&Ds. We use this section to describe the DBP investigators, the basis of their selection, and outline their interaction with TR&Ds. Ten of the 15 DBPs are presented in detail; detailed descriptions for the five others are provided in the Appendix. Each Aim of each TR&D has at least three subscribed DBPs. DBPs chosen represent specific technological roadblocks that are generally acknowledged in the field. We will refine our methodologies and technologies by working towards surpassing these roadblocks. Solving these problems will produce results that, in turn, open up new biological questions. These questions will, in turn, pose new technical challenges in their solution, starting a new round of technology development.

膜蛋白生产和分析中心（COMPPER）选择了15个DBPs， 每个TR& D的驱动力。我们使用本节来描述DBP 调查人员，他们的基础 选择，并概述他们与TR& D的互动。详细介绍了15个DBPs中的10个;详细 其他五项的说明载于附录。每个TR&D的每个目标至少有三个订阅 DBP。选定的DBP代表了该领域普遍承认的具体技术障碍。 我们将通过努力克服这些障碍来完善我们的方法和技术。解决 这些问题将产生的结果，反过来，开辟新的生物学问题。这些问题将在 反过来，提出了新的技术挑战，在他们的解决方案，开始了新一轮的技术发展。