Trans-omics Analysis to Unravel Molecular Underpinnings of Heart, Lung and Blood Disease Risk Factors
Trans-omics Analysis to Unravel Molecular Underpinnings of Heart, Lung and Blood Disease Risk Factors
批准号:
9524641
负责人:
Bing Yu
金额:
$49.47万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-05-01 至 2020-04-30
关键词:
African AmericanAmericanAtherosclerosis Risk in CommunitiesBioinformaticsBiometryBloodBlood PressureCloud ComputingComputational BiologyDataDiseaseEnhancersEquilibriumEthnic OriginEthnic groupEtiologyEuropeanExonsFramingham Heart StudyFrequenciesFunctional disorderGene FrequencyGenesGeneticGenetic DeterminismGenomicsGoalsHeartHeart DiseasesHematological DiseaseHemostatic functionHispanic AmericansHispanic Community Health Study/Study of LatinosIndividualInterventionJackson Heart StudyLinkLungLung diseasesMeasuresMediatingMediationMeta-AnalysisMetabolicMetabolic PathwayMinorMinorityModelingMolecularMolecular TargetMorbidity - disease rateMulti-Ethnic Study of AtherosclerosisMultivariate AnalysisNational Heart, Lung, and Blood InstituteNetwork-basedPathway interactionsPatternPopulationPositioning AttributePreventionQuantitative Trait LociRegulationResearchResourcesRisk FactorsRoleStructureTechnologyTestingTrans-Omics for Precision MedicineVariantburden of illnesscardiogenesiscohortdisorder riskethnic differencegene environment interactiongene productgenetic variantgenome sequencinggenome-wideinsightmetabolomemetabolomicsmortalitymultiple omicsnovelpreventpromoterpulmonary functionresponsesecondary analysissexstatisticstraitwhole genome
中文摘要
摘要
英文摘要
ABSTRACT
Heart, lung, and blood (HLB) traits, including blood pressure, pulmonary function and measures of hemostasis,
can predict morbidity and mortality. Understanding the regulation of these HLB traits is essential to decrease
disease burden. Despite successful identification of genetic variants associated HLB traits over the last decade,
the underlying mechanism of how genetic variants regulate these traits remains unclear. Circulating metabolites,
the ultimate products of gene and environment interaction, holds promise to link genetic variants, metabolic
changes to HLB traits. Multiple genetic variants that influence circulating metabolites have been identified,
however, the role of these metabolic-related loci on HLB traits is understudied. Ethnic differences in the
distribution of HLB traits, as well as disease risk are well-known, but current multi-omic findings are largely driven
by European ancestry. Few studies have examined the metabolic influence on HLB traits in multiple ethnic
groups. The overall objective of this application is to identify metabolic signatures related to HLB traits and
genetic loci influencing circulating metabolites in multi-ethnic populations, and utilize these findings to identify
molecular pathways that regulate HLB traits. We propose to conduct this project in five TOPMed cohorts,
including the Atherosclerosis Risk in Communities (ARIC) study, the Framingham Heart Study (FHS), the
Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the Jackson Heart Study (JHS), and the Multi-
Ethnic Study of Atherosclerosis (MESA), with a balance of European Americans, African Americans and Hispanic
Americans. We will leverage the unique resources from each study on existing whole genome sequencing (WGS)
data, metabolome profiles, multiple HLB traits, and utilize the TOPMed Cloud Computing Pilot Analysis
Commons for the computational engine. Our aims are: (1) to identify metabolic signatures associated with HLB
traits, including blood pressure, pulmonary function and measures of hemostasis; (2) to identify genetic
determinants of circulating metabolites; and (3) integrating Aims 1 and 2 omics findings to highlight causal
pathways associated with the regulation of HLB traits. Our team is uniquely positioned, given our expertise in
metabolome profiling, genomics, HLB traits, biostatistics and bioinformatics. The results of this research will
enable continued scientific progress toward an understanding of HLB disease pathophysiology, with direct
implications for prevention and potential therapies.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Molecular Determinants of Atherosclerotic Cardiovascular Disease in Multi-ethnic Populations
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批准号:10650109
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项目类别:
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资助金额:$78.44万
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财政年份:2023
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负责人:Bing Yu
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依托单位:
Metabolic Signatures Underlying Cardiac Function for Heart Failure in Multi-Ethnic Populations
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批准号:9902518
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项目类别:
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资助金额:$76.32万
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财政年份:2018
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负责人:Bing Yu
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依托单位:
Longitudinal Assessment of Tumor Hypoxia in vivo Using Near-Infrared Spectroscopy
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批准号:9415230
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项目类别:
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资助金额:$39.91万
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财政年份:2016
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负责人:Bing Yu
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依托单位:
Longitudinal Assessment of Tumor Hypoxia in vivo Using Near-Infrared Spectroscopy
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批准号:9023179
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项目类别:
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资助金额:$6.35万
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财政年份:2016
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负责人:Bing Yu
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依托单位:
A smart fiber optic sensor for in vivo tissue optical spectroscopy
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批准号:8534367
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项目类别:
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资助金额:$4.66万
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财政年份:2012
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负责人:Bing Yu
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依托单位:
A smart fiber optic sensor for in vivo tissue optical spectroscopy
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批准号:7978402
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项目类别:
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资助金额:$7.85万
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财政年份:2010
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负责人:Bing Yu
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依托单位:
A smart fiber optic sensor for in vivo tissue optical spectroscopy
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批准号:8117005
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项目类别:
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资助金额:$2.67万
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财政年份:2010
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负责人:Bing Yu
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依托单位:
海外基金