A smart fiber optic sensor for in vivo tissue optical spectroscopy

用于体内组织光谱的智能光纤传感器

• 批准号: 8117005
• 负责人: Bing Yu
• 金额: $ 2.67万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-07-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8117005
• 关键词: Affect; Calibration; Cervical Cancer Screening; Cervix Uteri; Consumption; Country; Coupling; Data Analyses; Death Rate; Dependence; Detection; Developing Countries; Devices; Diagnosis; Diagnostic; Diffuse; Early Diagnosis; Environment; Epithelial; Evaluation; Fiber; Fiber Optics; Gases; Goals; Grant; Haiti; Hospitals; Incidence; Light; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measurement; Measures; Medical; Metric; Modeling; Optics; Oral cavity; Oral mucous membrane structure; Outcome; Patients; Performance; Physiological; Physiology; Power Sources; Premalignant; Process; Property; Public Health; Research; Research Infrastructure; Resolution; Resources; Sampling; Screening for Oral Cancer; Screening procedure; Site; Source; Spectrum Analysis; Staging; System; Technology; Test Result; Testing; Time; Tissue Extracts; Tissue Sample; Tissues; Validation; Variant; Woman; Work; absorption; cancer diagnosis; charge coupled device camera; cost; design; design and construction; global health; healthy volunteer; in vivo; innovation; instrument; laptop; malignant mouth neoplasm; mortality; oral tissue; photonics; pressure; programs; public health relevance; response; sensor; soft tissue; tissue phantom; volunteer

DESCRIPTION (provided by applicant): Cancer, such as oral and cervical cancer, is a growing global health problem that disproportionately impacts the developing world. Each year, over 481,000 new cases of oral cancer are diagnosed worldwide, with a 5- year mortality of ~50% and nearly two-thirds of which occurs in developing world. Cervical cancer is the second most common cancer in women with an incidence and death rate of 16 and 9 per 100,000 women, respectively, and 80% of cases occur in the developing world. The high death rate in developing countries is largely due to the fact that these countries do not have the appropriate infrastructure and resources to support the organized screening and diagnostic programs that are available in the U.S. The optical absorption and scattering properties of epithelial tissues reflect their underlying physiological and morphological properties. Optical spectroscopy, particularly diffuse reflectance spectroscopy, can be used to noninvasively quantify these tissue properties and has shown promise for diagnosis of early precancerous changes in the cervix and oral cavity by our group as well as others. The long term objective of this proposal is to develop a portable, easy-to-use and low cost, yet accurate and reliable optical device that can aid in the screening and diagnosis of oral and cervical cancer at an early stage and that is well suited for use in a low-resource setting. The objective of the proposed research is to develop a portable, low-power consumption, smart fiber-optic sensor and to establish its performance metrics on tissue-mimicking phantoms and healthy oral tissues. The goals will be achieved by the use of state-of-the-art photonics components, such as LEDs and USB spectrometers, and an innovative smart fiber-optic probe. The smart probe will integrate into a single fiber-optic probe a sample channel for tissue optical spectroscopy, a self-calibration channel for real-time instrument calibration, and an interferometric pressure sensor for the control of the probe pressure at the probe-to-tissue interface. The specific aims of the proposed work are: (1) design and construction of the smart sensor system for performing visible diffuse reflectance spectroscopy of epithelial tissues in vivo; (2) verification of the accuracy of the smart sensor system in extraction of optical properties on tissue phantoms and in measuring pressure in a pressure test chamber; and (3) an evaluation of the effects of probe pressure on the measured tissue parameters and how well the probe pressure can be controlled with the smart sensor in healthy volunteers. Successful completion of the objectives of this research will result in a compact smart fiber-optic sensor system which will be demonstrated to obtain accurate, reproducible and quantitative measurements of tissue absorption and scattering contrast with applications to global health screening of cervical and oral cancers. Future research efforts will focus on deploying this technology for testing early screening strategies in resource poor environments. Dr. Ramanujam with whom the PI collaborates has a Duke Global health grant to initiate optical spectroscopy studies on patients suspected to have cervical cancer in Haiti. PUBLIC HEALTH RELEVANCE: The goal of this R03 proposal is to develop a portable, low power-consumption, and low-cost smart fiber-optic sensor device that can be used to obtain accurate, reproducible and quantitative measurements of absorption and scattering contrast of intact tissues with applications to global health screening of cervical and oral cancers. The proposed research is significantly relevant to public health due to the potential to contribute to the improvement of screening oral and cervical cancer, and thus the reduction of mortality rate worldwide.

描述(申请人提供)：癌症，如口腔癌和宫颈癌，是一个日益严重的全球健康问题，对发展中国家的影响不成比例。全世界每年新诊断的口腔癌病例超过481,000例，5年死亡率约为50%，其中近三分之二发生在发展中国家。宫颈癌是妇女中第二常见的癌症，发病率和死亡率分别为每10万名妇女中有16例和9例，80%的病例发生在发展中国家。发展中国家的高死亡率在很大程度上是因为这些国家没有适当的基础设施和资源来支持美国现有的有组织的筛查和诊断计划。上皮组织的光吸收和散射特性反映了它们潜在的生理和形态特性。光谱学，特别是漫反射光谱学，可以用来非侵入性地量化这些组织特性，并显示出我们小组和其他人对宫颈和口腔早期癌前病变的诊断前景。这项提议的长期目标是开发一种便携式、易用、低成本、但准确可靠的光学设备，可以帮助口腔和宫颈癌的早期筛查和诊断，并且非常适合在低资源环境下使用。这项研究的目的是开发一种便携式、低功耗的智能光纤传感器，并建立其在模拟组织模型和健康口腔组织上的性能指标。这些目标将通过使用最先进的光电子元件，如LED和USB光谱仪，以及创新的智能光纤探头来实现。智能探头将集成到单个光纤探头中，其中包括用于组织光学光谱分析的样品通道、用于实时仪器校准的自校准通道，以及用于控制探头与组织界面处的探头压力的干涉压力传感器。拟议工作的具体目标是：(1)设计和建造用于对活体上皮组织进行可见漫反射光谱的智能传感器系统；(2)验证智能传感器系统在提取组织模体的光学属性和在压力试验室中测量压力的准确性；以及(3)评估探头压力对测量的组织参数的影响，以及使用智能传感器在健康志愿者中控制探头压力的程度。这项研究的目标的成功完成将导致一种紧凑的智能光纤传感器系统，该系统将被证明可以获得准确、可重复和定量的组织吸收和散射测量，与应用于全球宫颈癌和口腔癌健康筛查形成对比。未来的研究工作将侧重于部署这项技术，在资源匮乏的环境中测试早期筛查策略。与PI合作的Ramanujam博士获得了杜克全球医疗补助，以启动对海地疑似宫颈癌患者的光谱学研究。 与公共健康相关：R03提案的目标是开发一种便携式、低功耗和低成本的智能光纤传感器设备，可用于获得完整组织的吸收和散射对比度的准确、可重复性和定量测量，并应用于全球宫颈癌和口腔癌健康筛查。这项拟议的研究与公共健康密切相关，因为它有可能有助于改进口腔癌和宫颈癌的筛查，从而降低全球的死亡率。