Addressing Poverty-Related Barriers to Prevent Obesity Beginning in Infancy

描述（由申请人提供）：母婴喂养方式，定义为母亲调节婴儿喂养的方法，是连接贫困和儿童肥胖的关键，潜在可修改的中介。有证据表明，与贫困有关的风险直接影响喂养方式，并对参与干预造成障碍。这表明需要解决风险和障碍，以提高干预的影响。儿科平台是解决这些风险和障碍的一个机会，因为它们能够从婴儿早期开始接触到有贫困相关风险的低收入家庭。候选人提出了一个为期五年的指导支持期，以获得在婴儿期开始的贫困背景下制定改善肥胖预防战略的专门知识。候选人是儿科助理教授，长期目标是成为一名独立的临床研究调查员。这一目标将通过来自发展行为儿科学、应用发展心理学、营养科学和生物统计学等领域的多学科专家导师、正式课程和其他职业发展活动的培训来实现。她将获得以下方面的高级技能：1)将发展心理学的理论框架应用于以患者为导向的研究，解决与贫困相关的风险；2)评估母婴喂养相互作用的最新方法；3)重复测量的复杂定量纵向数据分析；4)定性研究方法，以确定低收入家庭参与干预的障碍和促进因素；5)干预措施制定与评价；还有拨款申请。这些目标的实际应用将通过三个研究目标来完成。在Aim 1中，Gross博士将对一项正在进行的大型早期肥胖预防干预研究的纵向数据进行二次分析，以系统地描述与贫困相关的风险与母婴喂养方式之间的关系，以及这些喂养方式对热量摄入和婴儿体重轨迹的影响程度。在目标2中，Gross博士将使用定性方法，为解决与贫困相关的风险和障碍的战略概念化和发展提供信息，这些风险和障碍可以纳入行为改变干预措施，并纳入人口可扩展的初级保健平台。在目标3，格罗斯博士将试点测试这些策略的可行性实施和获得效应大小的初步估计。该提案的成功实施将导致R01申请，以测试肥胖预防干预措施的有效性，该干预措施通过人口可扩展的基于初级保健的平台来解决与贫困相关的风险和障碍，以增加响应性母婴喂养方式并减少早期儿童肥胖。

DESCRIPTION (provided by applicant): Maternal-infant feeding style, defined as a mother's approach to regulating infant feeding, is a critical, potentially modifiable mediator linking povery and child obesity. Evidence has documented that poverty-related risks directly impact feeding styles and create barriers to intervention engagement. This suggests the need to address both risks and barriers to improve intervention impact. Pediatric platforms represent an opportunity to address these risks and barriers due to their ability to access low-income families with poverty-related risks beginning in early infancy. The candidate proposes a mentored support period of five years to acquire expertise in developing strategies to improve obesity prevention in the context of poverty beginning during infancy. The candidate is an Assistant Professor of Pediatrics with the long-term goal of becoming an independent clinical research investigator. This goal will be achieved through training from expert multidisciplinary mentors from the fields of developmental-behavioral pediatrics, applied developmental psychology, nutrition science and biostatistics, formal coursework and other career development activities. She will gain advanced skills in: 1) applying theoretical frameworks from developmental psychology to patient-oriented research addressing poverty-related risks; 2) state-of-the-art methodologies for assessing maternal-infant feeding interactions; 3) complex quantitative longitudinal data analysis with repeated measures; 4) qualitative research methodologies to identify barriers and facilitators of intervention engagement with low-income families; 5) intervention development and evaluation; and 6) grant writing. The practical application of these goals will be accomplished through three study aims. In Aim 1, Dr. Gross will conduct a secondary analysis of longitudinal data from a large ongoing study of an early obesity prevention intervention to systematically describe the relationships between poverty-related risks and maternal-infant feeding styles and the degree to which these styles impact caloric intake and infant weight trajectories. In Aim 2, Dr. Gross will use qualitative methodologies to inform the conceptualization and development of strategies to address poverty-related risks and barriers that can be incorporated into a behavior change intervention and integrated into a population-scalable primary care-based platform. In Aim 3, Dr. Gross will pilot test these strategies for feasibility of implementation and obtaining preliminary estimates of effect size. The successful execution of this proposal will lead to an R01 application to test the efficacy of an obesity prevention intervention that addresses poverty-related risks and barriers using a population-scalable primary care-based platform to increase responsive maternal-infant feeding styles and reduce early child obesity.