NADPH oxidase in pathological angiogenesis in solid tumours and retina

NADPH 氧化酶在实体瘤和视网膜病理性血管生成中的作用

• 批准号: nhmrc : 566911
• 负责人: Prof Fan Jiang
• 金额: $ 38.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nadph-oxidase-pathological-tumours-retina/82939
• 关键词: NADPH; oxidase; pathological; angiogenesis; solid

Understanding blood vessel growth has profound clinical implications for many diseases. Blocking vessel growth is a promising strategy for treatment of cancer and eye complications accompanying diabetes, whereas treatments to stimulate new vessel growth will treat ischemic disorders ie. heart attack and stroke. Here we investigate whether targeting an enzyme that grows blood vessels has potential for making drugs to stop tumor growth or eye damage that occurs with diabetes and premature births.

了解血管生长对许多疾病具有深远的临床意义。阻断血管生长是治疗癌症和伴随糖尿病的眼部并发症的一种有前途的策略，而刺激新血管生长的治疗将治疗缺血性疾病，即糖尿病。心脏病和中风在这里，我们研究是否靶向生长血管的酶有可能制造药物来阻止肿瘤生长或糖尿病和早产引起的眼损伤。