Study of Ovarian Aging and Reserve in Young Women (SOAR)

年轻女性卵巢衰老和储备的研究（SOAR）

• 批准号: 10359026
• 负责人: Erica E Marsh
• 金额: $ 58.3万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10359026
• 关键词: Address; Affect; African American; Age; Aging; Ancillary Study; Antral; Biolectric Impedance; Biological; Biological Assay; Birth; Body fat; Body mass index; Child; Childbirth; Cohort Studies; Counseling; Cross-Sectional Studies; Data; Delayed Childbearing; Demographic Factors; Disease; Environment; Environmental Risk Factor; Epidemic; European; Family; Fertility; Fertilization; Fibroid Tumor; First Births; Follicle Stimulating Hormone; Glucose; Goals; Grant; Health; Health behavior; Impaired fasting glycaemia; Knowledge; Leptin; Life Style; Lipids; Longitudinal Studies; Longitudinal cohort; Longitudinal cohort study; Maternal Age; Measurement; Measures; Methods; Modeling; National Institute of Environmental Health Sciences; Natural History; OGTT; Obesity; Ovarian aging; Ovary; Pattern; Phenotype; Population; Reproductive History; Research Design; Risk Factors; Role; Sampling; Surveys; Testing; Time; United States; Woman; abdominal fat; aged; base; clinically significant; cohort; diminished ovarian reserve; egg; glucose metabolism; hormonal contraception; improved; innovation; interest; longitudinal dataset; mullerian-inhibiting hormone; novel; ovarian reserve; proliferative phase Menstrual cycle; prospective; reproductive; reproductive outcome; trend; young woman

The average age for a woman to have her first child has been increasing for the last three decades in the United States, making our understanding of ovarian aging and its negative effect on the ovarian reserve—a measure of the capacity of the ovary to produce eggs capable of fertilization—increasingly important. Yet, we know very little about other factors in reproductive-age women that might affect the ovarian reserve, beyond aging itself. This proposal, titled Study of Ovarian Aging and Reserve in Young Women (SOAR), seeks to address the significant gap in our knowledge of factors—particularly modifiable factors—that affect ovarian reserve and might accelerate its decrease in young women. To achieve this goal, we will leverage the ongoing NIEHS Study of Environment, Lifestyle and Fibroids (SELF), which is following a cohort of 1,696 African- American women between the ages of 23-34 years over a five-year period. In this group of young women, we will assess changes in the ovarian reserve by tracking three different measures of the ovarian reserve: anti- Müllerian hormone (AMH), early follicular phase follicle-stimulating hormone (FSH), and antral follicle count (AFC). In addition to collecting survey data, we will also perform oral glucose tolerance testing (OGTT) and anthropometric and bioelectrical impedance analysis (BIA) measurements to more precisely determine the roles of glucose metabolism and obesity on the ovarian reserve. The results of our study will be clinically significant as we currently have limited longitudinal data for counseling women on risk factors for decreased ovarian reserve. Our study design is innovative in that we will use overlapping measures of the ovarian reserve and group-based trajectory modeling to determine correlates associated with decreased ovarian reserve. Specifically, we will determine the demographic, health-behavior, reproductive, and environmental factors associated with decreased AMH (as a measure of the ovarian reserve) over time (Aim 1), determine the association between various measures of obesity and decreased ovarian reserve (Aim 2), and determine the association between glucose dysregulation and decreased ovarian reserve (Aim 3). The proposed prospective longitudinal cohort study will determine the natural history of and factors associated with the change in ovarian reserve over time. Further, it will add to the extremely limited data by generating the largest set of longitudinal data on AMH and ovarian reserve in the United States to date, which will benefit all women.

过去三十年来，女性生育第一个孩子的平均年龄一直在增加 美国，让我们了解卵巢衰老及其对卵巢储备的负面影响—— 衡量卵巢产生受精卵子的能力的指标——越来越重要。然而，我们 对于育龄女性可能影响卵巢储备的其他因素知之甚少，除了 衰老本身。该提案题为“年轻女性卵巢衰老和储备研究”(SOAR)，旨在 解决我们对影响卵巢的因素（尤其是可改变的因素）的认识上的重大差距 保留并可能加速其在年轻女性中的减少。为了实现这一目标，我们将利用持续的 NIEHS 环境、生活方式和子宫肌瘤研究 (SELF)，该研究对 1,696 名非洲人进行了跟踪调查 五年内年龄在 23 至 34 岁之间的美国女性。在这群年轻女性中，我们 将通过跟踪卵巢储备的三种不同指标来评估卵巢储备的变化： 苗勒管激素 (AMH)、卵泡早期促卵泡激素 (FSH) 和窦卵泡计数 （亚足联）。除了收集调查数据外，我们还将进行口服葡萄糖耐量测试（OGTT）和 人体测量和生物电阻抗分析 (BIA) 测量可更精确地确定 葡萄糖代谢和肥胖对卵巢储备的作用。我们的研究结果将在临床上 意义重大，因为我们目前可用于向妇女提供关于生育能力下降风险因素咨询的纵向数据有限。 卵巢储备。我们的研究设计具有创新性，因为我们将使用卵巢储备的重叠测量方法 和基于群体的轨迹建模，以确定与卵巢储备下降相关的相关性。 具体来说，我们将确定人口、健康行为、生殖和环境因素 随着时间的推移，AMH（作为卵巢储备的衡量指标）下降与相关（目标 1），确定 各种肥胖指标与卵巢储备功能下降之间的关联（目标 2），并确定 葡萄糖失调与卵巢储备功能下降之间的关联（目标 3）。拟议的前瞻性 纵向队列研究将确定卵巢变化的自然史和相关因素 随着时间的推移预留。此外，它将通过生成最大的纵向数据集来添加极其有限的数据。 美国迄今为止有关 AMH 和卵巢储备的数据，这将使所有女性受益。