Biomedical Prevensions

生物医学预防措施

• 批准号: 9531262
• 负责人: Amy Lynn Corneli
• 金额: $ 1.53万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9531262
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Aging; Area; Behavioral; Biometry; Collaborations; Communities; Community Outreach; Coordination and Collaboration; Databases; Environment; Event; Evolution; Faculty Recruitment; Funding; Grant; Growth; HIV; HIV vaccine; Interdisciplinary Study; Leadership; Medicine; Mental Health; Mentors; Mission; Modeling; Operative Surgical Procedures; Outcome; Patients; Process; Research; Research Infrastructure; Research Personnel; Services; Solid; Specimen; Strategic Planning; Substance abuse problem; Technology; Training; Underrepresented Minority; United States National Institutes of Health; Vaccine Design; biobank; co-infection; cost effective; innovation; medical schools; social; vaccine evaluation; working group

The principal mission of the Duke Center for AIDS Research (CFAR) is to establish comprehensive infrastructure support to an academic research environment that will effectively promote collaboration and coordination among the community of HIV/AIDS investigators at Duke and throughout the national CFAR network, thereby enhancing both the quality and quantity of their significant contributions and overall impact to the field. In this competitive renewal application, the Duke CFAR builds upon our accomplishments of the previous funding cycle and expands the overall infrastructure and programmatic support to continue to provide cost effective state-of-the-art services and catalyzing collaborative HIV/AIDS research initiatives at Duke. A solid basis is formed by both our highly successful Small Grant mechanism aimed primarily at early stage investigators and our equally successful faculty recruitment efforts. Through an effective Strategic Planning Process, the CFAR leadership has identified seven Specific Aims to guide the CFAR’s growth and evolution over the next 5 years. These are: 1) to provide administrative and scientific leadership and continue to build and engage Strategic Partnerships, 2) to provide mentoring and support for innovative HIV/AIDS research through a comprehensive set of mechanisms, including Small Grants, faculty recruitments, and Scientific Working Group activities, 3) to provide access to highly advanced technologies and training through new Core services, 4) to provide highly innovative and proactive biostatistics and computational support, 5) to provide ready access to patient specimens and expanded community outreach, 6) to support interdisciplinary research on social and behavioral determinants of HIV-related outcomes, and 7) to support NIH initiatives and promote inter-CFAR collaborations. The CFAR will expand its efforts to attract underrepresented minorities to HIV/AIDS research through a new partnership with the Duke Office of Biomedical Graduate Diversity. We also will seek to further engage our network of Strategic Partnerships by expanding the Small Grant targeted RFA/co-funding model initiated in the previous funding cycle between the CFAR and Department of Medicine. This expansion, as well as continued support for the newly established CFAR Database and Biorepository and CFAR events, will be enhanced by a significant increase in Institutional Support from Duke’s School of Medicine and Department of Surgery. Through our Strategic Planning process, we have identified five priority areas that represent opportunities for innovative research at Duke: 1) AIDS-related Malignancies and Co-Infections, 2) HIV and Aging, 3) Latency and Eradication, 4) Mental Health, Substance Abuse, and HIV Outcomes and 5) HIV Vaccine Design and Evaluation. The CFAR is invigorated by the potential to develop and further explore these opportunities through closer collaborative interactions at Duke and across the CFAR network.

杜克艾滋病研究中心（CFAR）的主要使命是建立全面的 为学术研究环境提供基础设施支持，以有效促进合作， 协调杜克和全国CFAR的艾滋病毒/艾滋病调查人员 网络，从而提高其重大贡献和总体影响的质量和数量， 外地在这份竞争性续签申请中，杜克CFAR以我们在 上一个供资周期，并扩大总体基础设施和方案支助，以继续提供 具有成本效益的最先进的服务和催化合作艾滋病毒/艾滋病研究计划在杜克。一 我们非常成功的小额赠款机制，主要针对早期阶段， 调查人员和我们同样成功的教师招聘工作。通过有效的战略规划 在这一过程中，CFAR领导层确定了七个具体目标，以指导CFAR的发展和演变 在接下来的五年里。这些是：1）提供行政和科学领导，继续建立 并参与战略伙伴关系，2）为创新的艾滋病毒/艾滋病研究提供指导和支持 通过一套全面的机制，包括小额赠款，教师招聘和科学 工作组的活动，3）通过新的核心技术提供获得先进技术和培训的机会， 服务，4）提供高度创新和积极主动的生物统计和计算支持，5）提供 随时获取患者标本和扩大社区外展，6）支持跨学科研究 关于艾滋病毒相关结果的社会和行为决定因素，以及7）支持NIH倡议并促进 CFAR之间的合作。CFAR将扩大努力，吸引代表性不足的少数群体关注艾滋病毒/艾滋病 通过与生物医学研究生多样性杜克办公室的新伙伴关系进行研究。我们还将寻求 通过扩大针对RFA/共同资助的小额赠款，进一步参与我们的战略伙伴关系网络 在CFAR和医学部之间的上一个供资周期中启动的模式。这种扩张， 以及继续支持新建立的CFAR数据库和生物储存库以及CFAR活动， 将通过杜克医学院的机构支持的显著增加来加强， 外科。通过我们的战略规划过程，我们确定了五个优先领域， 代表杜克创新研究的机会：1）艾滋病相关的恶性肿瘤和合并感染，2） 艾滋病毒和老龄化，3）潜伏期和根除，4）心理健康，药物滥用和艾滋病毒的结果和5） HIV疫苗的设计和评估。CFAR的发展潜力和进一步探索 通过在杜克和整个CFAR网络更密切的合作互动，这些机会。