Bone Imaging Core

骨成像核心

• 批准号: 10495745
• 负责人: Jesus Delgado-Calle
• 金额: $ 14.71万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-16 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10495745
• 关键词: Animal Model; Animals; Architecture; Arkansas; Bioinformatics; Biology; Biomechanics; Body Composition; Cellular biology; Centers of Research Excellence; Core Facility; Data; Disease; Doctor of Philosophy; Dual-Energy X-Ray Absorptiometry; Educational Activities; Educational workshop; Ensure; Equipment; Faculty; Finite Element Analysis; Foundations; Genetic; Genetic Models; Geometry; Goals; Histologic; Histology; Human Resources; Image; Knowledge; Laboratories; Malignant Bone Neoplasm; Measurement; Medical; Mentors; Modernization; Molecular; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Orthopedics; Osteomyelitis; Osteoporosis; Pathogenesis; Phase; Phenotype; Physiology; Porosity; Process; Productivity; Research; Research Personnel; Research Project Grants; Resolution; Resources; Roentgen Rays; Sampling; Scanning Electron Microscopy; Science; Services; Skeleton; System; Technology; Tissue imaging; Tissues; Training; Training and Education; Universities; Visualization; Work; analytical tool; bioluminescence imaging; bone; bone imaging; bone mass; bone strength; cortical bone; design; experience; experimental study; fluorescence imaging; human tissue; imaging approach; imaging modality; imaging study; in vivo; investigator training; longitudinal analysis; member; microCT; mineralization; mouse model; musculoskeletal imaging; new technology; novel; programs; routine imaging; skeletal; substantia spongiosa; success; tomography; two photon microscopy

PROJECT SUMMARY/ABSTRACT - CORE D The COBRE Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS) focuses on identifying the cellular and molecular causes underlying diseases and conditions that negatively impact the musculoskeletal system. Bone imaging and analytical technologies at the tissue and cellular level will be required to accomplish the goals of each Phase 2 research project. To fulfill this need, we will split the former Bone Histology and Imaging Core, established during Phase 1, into 2 independent but highly integrated new cores: the Bone Imaging Core (Core D) and the Histology, Biomechanics, and Human Tissue Core (Core C). Core D will operate as a centralized and shared core facility to assist Project Leaders and other CMDR members with the musculoskeletal imaging needed for their research efforts. The core will provide state- of-the-art imaging resources for quantitative characterization of tissue and cellular changes underlying the pathogenesis of the musculoskeletal disorders being studied. Thus, Core D will be critical for Project Leaders and the long-term success of the CMDR. This new core will consolidate existing and new equipment into a large, modern research space within the Department of Physiology and Cell Biology and will be staffed by well-trained technical personnel who will be supervised by the Core Director. Core D will pursue the following specific aims: 1) Establish the Bone Imaging Core; 2) Deliver state-of-the-art musculoskeletal imaging and introduce new analytical technologies to generate, analyze, and interpret bone-imaging data; and 3) Provide training in bone imaging and support educational activities. The success of Core D, together with the other CMDR cores, will benefit the work proposed in all research projects (Projects 1, 2, and 3) and expand the repertoire of analytical tools to meet the growing needs of CMDR members, as well as the other investigators at UAMS.

项目摘要/摘要-核心D 阿肯色医学大学科布雷肌肉骨骼疾病研究中心 科学(UAMS)专注于确定潜在的疾病和疾病的细胞和分子原因 这会对肌肉骨骼系统产生负面影响。组织和组织中的骨骼成像和分析技术 要完成每个第二阶段研究项目的目标，就需要细胞水平。为了满足这一需求，我们 将在第一阶段建立的前骨组织和成像核心部门分成两个独立但高度独立的部门 集成的新核心：骨成像核心(核心D)和组织学、生物力学和人体组织 核心(核心C)。核心D将作为集中和共享的核心设施运行，以协助项目负责人和其他人员 CMDR成员拥有他们的研究工作所需的肌肉骨骼成像。核心将提供状态- 最先进的成像资源，用于定量描述潜在的组织和细胞变化 肌肉骨骼疾病的发病机制正在研究中。因此，核心D对项目负责人来说至关重要 以及Cmdr的长期成功。这个新的核心将把现有的和新的设备整合成一个大型的、 生理学和细胞生物学系内的现代研究空间，将配备训练有素的工作人员 将由核心主管监督的技术人员。核心D将追求以下具体目标： 1)建立骨骼成像核心；2)提供最先进的肌肉骨骼成像，并推出新的 用于生成、分析和解释骨骼成像数据的分析技术；以及3)提供骨骼方面的培训 成像和支持教育活动。核心D与其他Cmdr核心的成功将 使所有研究项目(项目1、2和3)中提出的工作受益，并扩大分析能力 满足Cmdr成员以及UAMS其他调查人员日益增长的需求的工具。