Administrative Core

行政核心

• 批准号: 10495946
• 负责人: Anthony B. Firulli
• 金额: $ 16.56万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10495946
• 关键词: Animals; Applications Grants; Biohazardous Substance; Budgets; Clinical; Congenital Abnormality; Defect; Development; Disease; Ethics; Etiology; Goals; Growth; Individual; Institution; Molecular; Morphogenesis; Outcome; Output; Participant; Phenotype; Program Research Project Grants; Radiation; Reporting; Research Project Grants; Resource Sharing; Schedule; Services; Travel; United States National Institutes of Health; Ventricular; clinical prognosis; congenital heart disorder; meetings; pediatric patients; programs; symposium

Abstract Congenital heart disease (CHD) is the most common birth defect. Among various CHDs, defects that result in altered ventricular morphogenesis have the poorest clinical prognoses. Currently, there is a poor understanding of the molecular mechanisms and cellular etiology causative of the many forms of ventricular CHDs. The central theme of this Program Project Grant is to elucidate mechanisms that regulate growth and morphogenesis of the ventricle during development. Core A provides central administration of the Program Project Grant activities, which serves to enhance scientific interactions, resource sharing, collaborative interactions, and compliance requirements for all participants of this Program Project grant. The ultimate goal of Core A is to enhance Project efficiency and scientific output. Relevance: CHDs resulting in ventricle phenotypes have the poorest clinical outcomes. Thus, gaining an understanding of the etiology and molecular mechanisms that cause CHDs resulting in altered ventricular morphogenesis has the potential to benefit thousands of pediatric patients annually.

摘要 先天性心脏病(CHD)是最常见的出生缺陷。在各种CHD中，导致 心室形态发生改变的临床预后最差。目前，有一个贫穷的 对多种形式室性心动过速的分子机制和细胞病因学的认识 CHDS。本计划项目赠款的中心主题是阐明调节增长和 脑室发育过程中的形态发生。 核心A提供方案项目赠款活动的中央管理，这有助于加强 面向所有人的科学互动、资源共享、协作互动和合规要求 本计划项目资助的参与者。核心A的最终目标是提高项目效率和 科学成果。 相关性： 导致脑室表型的CHDS的临床结果最差。因此，了解了 导致CHDS导致心室形态发生改变的病因和分子机制 每年使数以千计的儿科患者受益的潜力。