Administrative Core

摘要 先天性心脏病（CHD）是最常见的出生缺陷。在各种CHD中，导致 心室形态发生改变的临床表现最差。目前，贫困 了解导致多种形式心室肌纤维化的分子机制和细胞病因学， 冠心病这项计划项目赠款的中心主题是阐明调节生长的机制， 心室在发育过程中的形态发生。 核心A为计划项目赠款活动提供中央管理， 科学互动、资源共享、协作互动以及所有人的合规要求 该计划项目资助的参与者。核心A的最终目标是提高项目效率， 科学产出。 相关性： 导致心室表型的CHD具有最差的临床结局。因此，了解 导致CHD的病因学和分子机制导致心室形态发生改变， 每年有可能使数千名儿科患者受益。

Abstract Congenital heart disease (CHD) is the most common birth defect. Among various CHDs, defects that result in altered ventricular morphogenesis have the poorest clinical prognoses. Currently, there is a poor understanding of the molecular mechanisms and cellular etiology causative of the many forms of ventricular CHDs. The central theme of this Program Project Grant is to elucidate mechanisms that regulate growth and morphogenesis of the ventricle during development. Core A provides central administration of the Program Project Grant activities, which serves to enhance scientific interactions, resource sharing, collaborative interactions, and compliance requirements for all participants of this Program Project grant. The ultimate goal of Core A is to enhance Project efficiency and scientific output. Relevance: CHDs resulting in ventricle phenotypes have the poorest clinical outcomes. Thus, gaining an understanding of the etiology and molecular mechanisms that cause CHDs resulting in altered ventricular morphogenesis has the potential to benefit thousands of pediatric patients annually.