Evaluation of Fever/Rash for Zika, Chikungunya, and Dengue virus in Mexico

这项研究评估了发热和/或皮疹的受试者，以确定感染寨卡病毒、基孔肯雅病毒或登革热病毒的受试者的百分比。该研究还比较了与每种病毒相关的临床体征、症状和实验室异常，以更好地说明每种病毒的特征。 该研究在几个不同的队列中招募了受试者，包括发热性皮疹队列（试图捕获急性寨卡/基孔肯雅/登革热感染），家庭队列（试图捕获无症状或症状轻微的受试者）和Guillain Barré患者队列。 此外，发热性皮疹队列的两个亚群有特殊随访。这包括妊娠人群，将对其进行分娩随访以确定妊娠结局，以及将对具有神经系统或认知表现的受试者进行评价以确定这些疾病的神经系统疾病谱。 考虑到疾病的严重程度，可能暴露于寨卡病毒的Guillain Barré受试者特别值得关注。患有Guillain Barré的受试者不需要有提示Zika或其他病毒的既往疾病。

This study evaluates subjects with fever and/or rash to determine the percentage of those infected by the Zika, Chikungunya, or Dengue virus. The study also compares the clinical signs, symptoms, and lab abnormalities related to each virus, to better specify each virus's characteristics. The study has enrolled subjects in several different cohorts including a febrile rash cohort (attempting to capture acute Zika/Chikungunya/Dengue infection), a household cohort (attempting to capture asymptomatic or minimally symptomatic subjects), and a cohort of those with Guillain Barré). Additionally, two subpopulations of the febrile rash cohort have special follow up. This includes the pregnant population, who will be followed through delivery to determine pregnancy outcomes, and those subjects with neurologic or cognitive manifestations who will be evaluated to determine the spectrum of neurologic disease seen with these diseases. Subjects with Guillain Barré with potential exposure to Zika virus are of special interest given the severity of disease. Subjects with Guillain Barré do not need to have a preceding illness suggestive of Zika or other viruses.