Evaluation of Fever/Rash for Zika, Chikungunya, and Dengue virus in Mexico

本研究评估有发热和/或皮疹的受试者，以确定感染寨卡病毒、基孔肯雅病毒或登革热病毒的百分比。该研究还比较了与每种病毒相关的临床体征、症状和实验室异常，以更好地确定每种病毒的特征。该研究纳入了几个不同队列的受试者，包括一个发热皮疹队列（试图捕获急性寨卡/基孔肯雅/登革热感染），一个家庭队列（试图捕获无症状或最低症状的受试者）和一个Guillain barr<s:1>患者队列。此外，热疹队列的两个亚群有特殊的随访。这包括孕妇，她们将被跟踪到分娩以确定妊娠结果，以及那些有神经系统或认知表现的受试者，他们将被评估以确定这些疾病所见的神经系统疾病的范围。考虑到疾病的严重程度，有可能接触寨卡病毒的格林巴勒斯患者特别值得关注。Guillain barr<s:1>患者不需要之前有提示寨卡病毒或其他病毒的疾病。

This study evaluates subjects with fever and/or rash to determine the percentage of those infected by the Zika, Chikungunya, or Dengue virus. The study also compares the clinical signs, symptoms, and lab abnormalities related to each virus, to better specify each virus's characteristics. The study has enrolled subjects in several different cohorts including a febrile rash cohort (attempting to capture acute Zika/Chikungunya/Dengue infection), a household cohort (attempting to capture asymptomatic or minimally symptomatic subjects), and a cohort of those with Guillain Barré). Additionally, two subpopulations of the febrile rash cohort have special follow up. This includes the pregnant population, who will be followed through delivery to determine pregnancy outcomes, and those subjects with neurologic or cognitive manifestations who will be evaluated to determine the spectrum of neurologic disease seen with these diseases. Subjects with Guillain Barré with potential exposure to Zika virus are of special interest given the severity of disease. Subjects with Guillain Barré do not need to have a preceding illness suggestive of Zika or other viruses.