Assessing the spatial heterogeneity in cardiovascular risk factors within and between blacks and whites

项目摘要/摘要 我的K01奖项的目标是让自己成为一名独立的心血管研究人员，具有以下方面的专业知识 空间统计和疾病测绘方法以及多学科研究团队的重要成员 致力于解决心血管疾病的差异。要实现这些目标，就需要有针对性的教学 培训和研究指导。 培训 拟议的职业发展和培训计划由四个不同部分组成：(1)职业指导 在方法学开发和合作心血管研究方面通过现场和 心血管和社会流行病学家以及空间统计学家和地理信息系统的非现场指导 专家；(2)旨在建立心血管和社会基础的有组织的课程作业 流行病学和与地理信息系统协作的空间方法高级培训； (3)利用所获得的培训领导创新研究；以及(4)在以下方面促进思想交流 通过参加会议和研讨会进行统计和流行病学研究。这些拟议的培训活动 将使我在心血管流行病学和心血管疾病差异方面有很好的基础。 这些活动也将集中于加深我对心血管疾病的了解，使我能够合理地评估 其相关危险因素在黑人和白人内部和之间的空间异质性。 研究 这项拟议的工作将探索环境因素与心血管健康(CVH)之间的关系。 在小区域局部尺度和区域尺度上随空间变化，重点关注CVH的空间变化 黑人和白人之间的差异以及CVH中黑白差异的空间差异。通过结合一种新的健康 利用新的空间方法，这项拟议的工作将更好地表征 黑人和白人以及黑人和白人差异的CVH的地理异质性。我们的新统计数据 方法将应用于两个非常丰富和独特的队列，动脉粥样硬化的多种族研究(MESA) 卒中(方面)队列的地理和种族差异原因。更大的目标 这项工作的重点是以一种为改善目标干预提供证据的方式来定义这些差异 建筑环境。此外，我们的发现将有助于支持知情的医疗政策，以改善 黑人和白人的心血管健康。

PROJECT SUMMARY/ABSTRACT My goal for the K01 award is to establish myself as an independent cardiovascular researcher with expertise in spatial statistics and disease mapping methods and an integral member of multidisciplinary research teams devoted to addressing cardiovascular disparities. Attaining these objectives will require focused didactic training and research guidance. Training The proposed career development and training plan consists of four distinct components: (1) career guidance and mentoring in methodological development and collaborative cardiovascular research through on-site and off-site mentoring by cardiovascular and social epidemiologists as well as spatial statisticians and GIS specialists; (2) structured coursework designed at establishing a basic foundation in cardiovascular and social epidemiology and advanced training in spatial methods in collaboration with geographic information systems; (3) leading innovative research utilizing the gained training; and (4) contributing in the exchange of ideas in statistics and epidemiology through conference and workshop attendance. These proposed training activities will allow me to become well grounded in cardiovascular epidemiology and cardiovascular disease disparities. These activities will also focus on deepening my understanding of CVD, enabling me to reasonably assess the spatial heterogeneity in its associated risk factors within and between blacks and whites. Research The proposed work will explore the extent to which environmental factors and cardiovascular health (CVH) vary over space at a small-area local scale and at a regional scale with a focus on spatial variation in CVH among blacks and whites and spatial variation in black-white disparities in CVH. By combining a novel health indicator, the CVH index, with novel spatial methods, this proposed work will better characterize the geographic heterogeneity in CVH for blacks and whites and for black-white disparities. Our novel statistical methods will be applied to two very rich and unique cohorts, the Multi-Ethnic Study of Atherosclerosis (MESA) cohort and the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. The larger goal of this work is to define these differences in a way that provides evidence for targeted interventions to improve the built environment. Additionally, our findings will help support informed health policies to improve the cardiovascular health of both blacks and whites.