Implementation and Evaluation of a Screening Tool for Sexual Dysfunction for Pediatric Cancer Survivors

小儿癌症幸存者性功能障碍筛查工具的实施和评估

• 批准号: 10448895
• 负责人: Jenna Demedis
• 金额: $ 21.66万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-21 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448895
• 关键词: Address; Adolescent and Young Adult; Adoption; Adult; Affect; Age; Arousal; Award; Cancer Survivorship; Child; Chronic; Client satisfaction; Clinic; Clinical; Clinical Trials; Colorado; Communication; Data; Detection; Development; Diagnosis; Dissemination and Implementation; Educational workshop; Effectiveness; Ensure; Environment; Evaluation; Feedback; Female; Fostering; Future; Goals; Health; Hybrids; Intervention; Interview; Knowledge; Long-Term Effects; Long-Term Survivors; Malignant Childhood Neoplasm; Malignant Neoplasms; Medical; Medical Records; Mental Health; Mentors; Mentorship; Methods; Modification; Multicenter Studies; Oncology; Oncology Group; Outcome; Outcomes Research; Pain; Patient Outcomes Assessments; Patients; Pattern; Pediatric Hematology; Pediatric Hospitals; Pediatric Oncology; Persons; Physiological; Population; Pragmatic clinical trial; Process; Program Development; Provider; Qualitative Research; Quality of Care; Quality of life; Questionnaires; Reach Effectiveness Adoption Implementation and Maintenance; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Proposals; Research Training; Science; Screening procedure; Sex Functioning; Sexual Dysfunction; Standardization; Surveys; Testing; Time; Training; Training Support; Translational Research; United States; Universities; University resources; Work; aged; career; career development; childhood cancer survivor; contextual factors; design; dissemination science; effectiveness evaluation; effectiveness implementation study; effectiveness implementation trial; effectiveness testing; experience; future implementation; health related quality of life; hybrid type 1 design; implementation evaluation; implementation facilitators; implementation framework; implementation outcomes; implementation science; improved; informant; innovation; intervention effect; multidisciplinary; neuro-oncology; patient oriented; patient-clinician communication; peer; pragmatic trial; preference; primary outcome; programs; prospective; randomized trial; recruit; research to practice; routine screening; satisfaction; screening; secondary outcome; sex; skills; social; socioeconomics; survivorship; tool; treatment as usual

PROJECT SUMMARY/ABSTRACT Background: Sexual dysfunction (SD) is estimated to occur in up to 50% of childhood cancer survivors (CCS) and has important implications for quality of life and mental health. Effective management of SD in AYA-CCS is substantially limited due to lack of screening and detection of SD in cancer survivorship settings. Adolescent and young adult-aged CCS (AYA-CCS) may be particularly vulnerable to SD and its under-recognition due to developmental challenges. This study addresses this critical barrier and serves as the first step in progressing toward the long-term goal of improving health-related quality of life in AYA CCS through improved screening, recognition and treatment of SD among CCS. Candidate: The proposed award will enable the candidate, Dr. Sopfe, to develop the skills necessary to progress toward her career as an independent researcher leading high quality pragmatic trials. Training: Specifically, Dr. Sopfe will gain experience in Dissemination & Implementation (D&I) science, pragmatic clinical trials, and mixed methods, which will propel her toward a research career aimed at developing and disseminating interventions to improve quality of life for CCS. In addition to experiential training through the research plan, Dr. Sopfe will benefit from a multidisciplinary mentorship team: Primary Mentor, Dr. Peterson (hybrid trials, qualitative research, patient-reported outcomes); Co-Mentor, Dr. Chow (pediatric cancer survivorship, clinical trials); and Methods Mentor, Dr. Studts (D&I, mixed methods). Dr. Sopfe’s training plan includes formal didactic coursework, workshops, and career development programs. Research Plan: This proposal’s overall objective is to use patient and provider stakeholder input to refine and test an approach to SD screening for AYA CCS in a clinic setting. Informed by D&I frameworks, this research proposal will used mixed methods and iterative testing and modification to refine an SD screening approach (Aim 1). This approach will be then tested in a pilot type 1 hybrid effectiveness-implementation study (Aims 2 and 3), employing mixed methods to assess patient and provider outcomes. Environment: The environment for this project is exceptional with a strong academic Section of Pediatric Hematology/Oncology/BMT at the University of Colorado, the resources of the University of Colorado Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS) (D&I Science Program, Qualitative & Mixed Methods Research Core). The clinical trial will occur through the 1) Children’s Hospital Colorado (CHCO) HOPE Survivorship Program; CHCO Neuro-Oncology group; and 3) Seattle Children’s Hospital Cancer Survivorship Program. This multiclinic design will ensure successful recruitment as well as increase generalizability of findings. Impact: The proposed study will serve as a necessary first step in improving screening, detection, and treatment of SD in AYA-CCS; future work will include establishing broader effectiveness our screening approach through a multicenter randomized trial, as well as development, testing, and dissemination of multidisciplinary interventions for SD in this population.

项目摘要/摘要 背景：性功能障碍（SD）估计发生在多达50％的儿童癌症存活率（CCS）中 并对生活质量和心理健康具有重要意义。 AYA-CCS中SD的有效管理是 由于缺乏筛查和癌症生存环境中SD的检测，由于缺乏筛查和检测而受到很大的限制。青少年和 年轻的成人CCS（AYA-CCS）可能特别容易受到SD及其识别的影响 发展挑战。这项研究解决了这一关键障碍，并作为进步的第一步 实现长期目标，即通过改进筛选，改善AYA CC中的健康相关生活质量， CCS中SD的识别和处理。候选人：拟议的奖项将使候选人博士成为候选人。 索普夫（Sopfe），以发展自己作为一名独立研究人员领先的独立研究人员所必需的技能 质量务实的试验。培训：特别是，Sopfe博士将获得传播和实施的经验 （D＆I）科学，务实的临床试验和混合方法，这将推动她朝着针对研究职业的目标 开发和传播干预措施以改善CCS的生活质量。除了专家培训 通过研究计划，Sopfe博士将从多学科心态团队中受益：主要导师，博士 彼得森（混合试验，定性研究，患者报告的结果）； Chow博士（小儿癌） 生存，临床试验）；和方法导师，Dr. Studts（D＆I，混合方法）。 Sopfe博士的培训计划 包括正式的教学课程，讲习班和职业发展计划。研究计划：这 提案的总体目标是使用患者和提供商利益相关者的意见来完善和测试SD的方法 在诊所环境中筛选AYA CCS。由D＆I框架告知，该研究建议将混合使用 方法和迭代测试和修改以完善SD筛选方法（AIM 1）。这种方法会 然后在试点1型混合有效性研究研究中进行测试（目标2和3），采用混合 评估患者和提供者结果的方法。环境：该项目的环境非常出色 科罗拉多大学的小儿血液学/肿瘤学/BMT的学术部分很强 科罗拉多大学成人和儿童财团的健康成果研究和分娩的资源 科学（协定）（D＆I科学计划，定性和混合方法研究核心）。临床试验将 通过1）科罗拉多州儿童医院（CHCO）希望幸存计划； CHCO神经肿瘤学 团体; 3）西雅图儿童医院癌症生存计划。这种多斜设计将确保 成功的招聘以及提高发现的普遍性。影响：拟议的研究将作为 改善AYA-CC中SD的筛查，检测和治疗的必要第一步；未来的工作将包括 通过多中心随机试验以及 该人群中SD多学科干预措施的开发，测试和传播。