Implementation and Evaluation of a Screening Tool for Sexual Dysfunction for Pediatric Cancer Survivors

小儿癌症幸存者性功能障碍筛查工具的实施和评估

基本信息

  • 批准号:
    10448895
  • 负责人:
  • 金额:
    $ 21.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-21 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Background: Sexual dysfunction (SD) is estimated to occur in up to 50% of childhood cancer survivors (CCS) and has important implications for quality of life and mental health. Effective management of SD in AYA-CCS is substantially limited due to lack of screening and detection of SD in cancer survivorship settings. Adolescent and young adult-aged CCS (AYA-CCS) may be particularly vulnerable to SD and its under-recognition due to developmental challenges. This study addresses this critical barrier and serves as the first step in progressing toward the long-term goal of improving health-related quality of life in AYA CCS through improved screening, recognition and treatment of SD among CCS. Candidate: The proposed award will enable the candidate, Dr. Sopfe, to develop the skills necessary to progress toward her career as an independent researcher leading high quality pragmatic trials. Training: Specifically, Dr. Sopfe will gain experience in Dissemination & Implementation (D&I) science, pragmatic clinical trials, and mixed methods, which will propel her toward a research career aimed at developing and disseminating interventions to improve quality of life for CCS. In addition to experiential training through the research plan, Dr. Sopfe will benefit from a multidisciplinary mentorship team: Primary Mentor, Dr. Peterson (hybrid trials, qualitative research, patient-reported outcomes); Co-Mentor, Dr. Chow (pediatric cancer survivorship, clinical trials); and Methods Mentor, Dr. Studts (D&I, mixed methods). Dr. Sopfe’s training plan includes formal didactic coursework, workshops, and career development programs. Research Plan: This proposal’s overall objective is to use patient and provider stakeholder input to refine and test an approach to SD screening for AYA CCS in a clinic setting. Informed by D&I frameworks, this research proposal will used mixed methods and iterative testing and modification to refine an SD screening approach (Aim 1). This approach will be then tested in a pilot type 1 hybrid effectiveness-implementation study (Aims 2 and 3), employing mixed methods to assess patient and provider outcomes. Environment: The environment for this project is exceptional with a strong academic Section of Pediatric Hematology/Oncology/BMT at the University of Colorado, the resources of the University of Colorado Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS) (D&I Science Program, Qualitative & Mixed Methods Research Core). The clinical trial will occur through the 1) Children’s Hospital Colorado (CHCO) HOPE Survivorship Program; CHCO Neuro-Oncology group; and 3) Seattle Children’s Hospital Cancer Survivorship Program. This multiclinic design will ensure successful recruitment as well as increase generalizability of findings. Impact: The proposed study will serve as a necessary first step in improving screening, detection, and treatment of SD in AYA-CCS; future work will include establishing broader effectiveness our screening approach through a multicenter randomized trial, as well as development, testing, and dissemination of multidisciplinary interventions for SD in this population.
项目总结/摘要 背景:据估计,高达50%的儿童癌症幸存者发生性功能障碍(SD)。 并对生活质量和心理健康有重要影响。AYA CCS中SD的有效管理是 由于在癌症存活率环境中缺乏SD的筛查和检测,因此基本上是有限的。青少年和 年轻的成年年龄的CCS(AYA-CCS)可能特别容易受到SD和它的认识不足,由于 发展挑战。这项研究解决了这一关键障碍,并作为第一步, 通过改善筛查,实现改善AYA CCS患者健康相关生活质量的长期目标, CCS中SD的识别和处理。候选人:拟议的奖项将使候选人,博士。 Sopfe,以发展必要的技能,朝着她的职业生涯作为一个独立的研究人员领先的高 质量务实的审判。培训:特别是,Sopfe博士将获得传播和实施方面的经验 (D&I)科学,务实的临床试验和混合方法,这将推动她走向一个研究生涯, 制定和传播干预措施,以提高CCS的生活质量。除了体验式培训 通过这项研究计划,Sopfe博士将受益于一个多学科的导师团队: Peterson(混合试验、定性研究、患者报告结局);共同导师,Dr. Chow(儿科癌症 生存率,临床试验);和方法导师,博士Studts(D&I,混合方法)。索普夫博士的训练计划 包括正式的教学课程,研讨会和职业发展计划。研究计划:此 提案的总体目标是利用患者和提供者利益相关者的意见来完善和测试SD方法 在临床环境中筛查AYA CCS。根据D&I框架,本研究建议将混合使用 方法和迭代测试和修改,以完善SD筛选方法(目标1)。这种方法将 然后在试点1型混合动力有效性实施研究(目标2和3)中进行测试,采用混合动力 评估患者和提供者结果的方法。环境:该项目的环境是特殊的 科罗拉多大学儿科血液学/肿瘤学/BMT学术部, 科罗拉多大学成人和儿童健康结果研究和提供联盟的资源 科学(ACCORDS)(D&I科学计划,定性和混合方法研究核心)。临床试验将 通过1)科罗拉多儿童医院(CHCO)HOPE生存计划; CHCO神经肿瘤学 西雅图儿童医院癌症生存计划。这种多诊所设计将确保 成功征聘以及提高调查结果普遍性。影响:拟议的研究将作为 这是改善AYA-CCS中SD筛查、检测和治疗的必要的第一步;未来的工作将包括 通过多中心随机试验建立更广泛的有效性,以及 在这一人群中开发、测试和传播多学科干预措施。

项目成果

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Jenna Demedis其他文献

Jenna Demedis的其他文献

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{{ truncateString('Jenna Demedis', 18)}}的其他基金

Implementation and Evaluation of a Screening Tool for Sexual Dysfunction for Pediatric Cancer Survivors
小儿癌症幸存者性功能障碍筛查工具的实施和评估
  • 批准号:
    10669609
  • 财政年份:
    2022
  • 资助金额:
    $ 21.66万
  • 项目类别:

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