Implementation and Evaluation of a Screening Tool for Sexual Dysfunction for Pediatric Cancer Survivors

小儿癌症幸存者性功能障碍筛查工具的实施和评估

• 批准号: 10448895
• 负责人: Jenna Demedis
• 金额: $ 21.66万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-21 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448895
• 关键词: Address; Adolescent and Young Adult; Adoption; Adult; Affect; Age; Arousal; Award; Cancer Survivorship; Child; Chronic; Client satisfaction; Clinic; Clinical; Clinical Trials; Colorado; Communication; Data; Detection; Development; Diagnosis; Dissemination and Implementation; Educational workshop; Effectiveness; Ensure; Environment; Evaluation; Feedback; Female; Fostering; Future; Goals; Health; Hybrids; Intervention; Interview; Knowledge; Long-Term Effects; Long-Term Survivors; Malignant Childhood Neoplasm; Malignant Neoplasms; Medical; Medical Records; Mental Health; Mentors; Mentorship; Methods; Modification; Multicenter Studies; Oncology; Oncology Group; Outcome; Outcomes Research; Pain; Patient Outcomes Assessments; Patients; Pattern; Pediatric Hematology; Pediatric Hospitals; Pediatric Oncology; Persons; Physiological; Population; Pragmatic clinical trial; Process; Program Development; Provider; Qualitative Research; Quality of Care; Quality of life; Questionnaires; Reach Effectiveness Adoption Implementation and Maintenance; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Proposals; Research Training; Science; Screening procedure; Sex Functioning; Sexual Dysfunction; Standardization; Surveys; Testing; Time; Training; Training Support; Translational Research; United States; Universities; University resources; Work; aged; career; career development; childhood cancer survivor; contextual factors; design; dissemination science; effectiveness evaluation; effectiveness implementation study; effectiveness implementation trial; effectiveness testing; experience; future implementation; health related quality of life; hybrid type 1 design; implementation evaluation; implementation facilitators; implementation framework; implementation outcomes; implementation science; improved; informant; innovation; intervention effect; multidisciplinary; neuro-oncology; patient oriented; patient-clinician communication; peer; pragmatic trial; preference; primary outcome; programs; prospective; randomized trial; recruit; research to practice; routine screening; satisfaction; screening; secondary outcome; sex; skills; social; socioeconomics; survivorship; tool; treatment as usual

PROJECT SUMMARY/ABSTRACT Background: Sexual dysfunction (SD) is estimated to occur in up to 50% of childhood cancer survivors (CCS) and has important implications for quality of life and mental health. Effective management of SD in AYA-CCS is substantially limited due to lack of screening and detection of SD in cancer survivorship settings. Adolescent and young adult-aged CCS (AYA-CCS) may be particularly vulnerable to SD and its under-recognition due to developmental challenges. This study addresses this critical barrier and serves as the first step in progressing toward the long-term goal of improving health-related quality of life in AYA CCS through improved screening, recognition and treatment of SD among CCS. Candidate: The proposed award will enable the candidate, Dr. Sopfe, to develop the skills necessary to progress toward her career as an independent researcher leading high quality pragmatic trials. Training: Specifically, Dr. Sopfe will gain experience in Dissemination & Implementation (D&I) science, pragmatic clinical trials, and mixed methods, which will propel her toward a research career aimed at developing and disseminating interventions to improve quality of life for CCS. In addition to experiential training through the research plan, Dr. Sopfe will benefit from a multidisciplinary mentorship team: Primary Mentor, Dr. Peterson (hybrid trials, qualitative research, patient-reported outcomes); Co-Mentor, Dr. Chow (pediatric cancer survivorship, clinical trials); and Methods Mentor, Dr. Studts (D&I, mixed methods). Dr. Sopfe’s training plan includes formal didactic coursework, workshops, and career development programs. Research Plan: This proposal’s overall objective is to use patient and provider stakeholder input to refine and test an approach to SD screening for AYA CCS in a clinic setting. Informed by D&I frameworks, this research proposal will used mixed methods and iterative testing and modification to refine an SD screening approach (Aim 1). This approach will be then tested in a pilot type 1 hybrid effectiveness-implementation study (Aims 2 and 3), employing mixed methods to assess patient and provider outcomes. Environment: The environment for this project is exceptional with a strong academic Section of Pediatric Hematology/Oncology/BMT at the University of Colorado, the resources of the University of Colorado Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS) (D&I Science Program, Qualitative & Mixed Methods Research Core). The clinical trial will occur through the 1) Children’s Hospital Colorado (CHCO) HOPE Survivorship Program; CHCO Neuro-Oncology group; and 3) Seattle Children’s Hospital Cancer Survivorship Program. This multiclinic design will ensure successful recruitment as well as increase generalizability of findings. Impact: The proposed study will serve as a necessary first step in improving screening, detection, and treatment of SD in AYA-CCS; future work will include establishing broader effectiveness our screening approach through a multicenter randomized trial, as well as development, testing, and dissemination of multidisciplinary interventions for SD in this population.

项目总结/文摘