Implementation and Evaluation of a Screening Tool for Sexual Dysfunction for Pediatric Cancer Survivors

小儿癌症幸存者性功能障碍筛查工具的实施和评估

• 批准号: 10448895
• 负责人: Jenna Demedis
• 金额: $ 21.66万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-21 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448895
• 关键词: Address; Adolescent and Young Adult; Adoption; Adult; Affect; Age; Arousal; Award; Cancer Survivorship; Child; Chronic; Client satisfaction; Clinic; Clinical; Clinical Trials; Colorado; Communication; Data; Detection; Development; Diagnosis; Dissemination and Implementation; Educational workshop; Effectiveness; Ensure; Environment; Evaluation; Feedback; Female; Fostering; Future; Goals; Health; Hybrids; Intervention; Interview; Knowledge; Long-Term Effects; Long-Term Survivors; Malignant Childhood Neoplasm; Malignant Neoplasms; Medical; Medical Records; Mental Health; Mentors; Mentorship; Methods; Modification; Multicenter Studies; Oncology; Oncology Group; Outcome; Outcomes Research; Pain; Patient Outcomes Assessments; Patients; Pattern; Pediatric Hematology; Pediatric Hospitals; Pediatric Oncology; Persons; Physiological; Population; Pragmatic clinical trial; Process; Program Development; Provider; Qualitative Research; Quality of Care; Quality of life; Questionnaires; Reach Effectiveness Adoption Implementation and Maintenance; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Proposals; Research Training; Science; Screening procedure; Sex Functioning; Sexual Dysfunction; Standardization; Surveys; Testing; Time; Training; Training Support; Translational Research; United States; Universities; University resources; Work; aged; career; career development; childhood cancer survivor; contextual factors; design; dissemination science; effectiveness evaluation; effectiveness implementation study; effectiveness implementation trial; effectiveness testing; experience; future implementation; health related quality of life; hybrid type 1 design; implementation evaluation; implementation facilitators; implementation framework; implementation outcomes; implementation science; improved; informant; innovation; intervention effect; multidisciplinary; neuro-oncology; patient oriented; patient-clinician communication; peer; pragmatic trial; preference; primary outcome; programs; prospective; randomized trial; recruit; research to practice; routine screening; satisfaction; screening; secondary outcome; sex; skills; social; socioeconomics; survivorship; tool; treatment as usual

PROJECT SUMMARY/ABSTRACT Background: Sexual dysfunction (SD) is estimated to occur in up to 50% of childhood cancer survivors (CCS) and has important implications for quality of life and mental health. Effective management of SD in AYA-CCS is substantially limited due to lack of screening and detection of SD in cancer survivorship settings. Adolescent and young adult-aged CCS (AYA-CCS) may be particularly vulnerable to SD and its under-recognition due to developmental challenges. This study addresses this critical barrier and serves as the first step in progressing toward the long-term goal of improving health-related quality of life in AYA CCS through improved screening, recognition and treatment of SD among CCS. Candidate: The proposed award will enable the candidate, Dr. Sopfe, to develop the skills necessary to progress toward her career as an independent researcher leading high quality pragmatic trials. Training: Specifically, Dr. Sopfe will gain experience in Dissemination & Implementation (D&I) science, pragmatic clinical trials, and mixed methods, which will propel her toward a research career aimed at developing and disseminating interventions to improve quality of life for CCS. In addition to experiential training through the research plan, Dr. Sopfe will benefit from a multidisciplinary mentorship team: Primary Mentor, Dr. Peterson (hybrid trials, qualitative research, patient-reported outcomes); Co-Mentor, Dr. Chow (pediatric cancer survivorship, clinical trials); and Methods Mentor, Dr. Studts (D&I, mixed methods). Dr. Sopfe’s training plan includes formal didactic coursework, workshops, and career development programs. Research Plan: This proposal’s overall objective is to use patient and provider stakeholder input to refine and test an approach to SD screening for AYA CCS in a clinic setting. Informed by D&I frameworks, this research proposal will used mixed methods and iterative testing and modification to refine an SD screening approach (Aim 1). This approach will be then tested in a pilot type 1 hybrid effectiveness-implementation study (Aims 2 and 3), employing mixed methods to assess patient and provider outcomes. Environment: The environment for this project is exceptional with a strong academic Section of Pediatric Hematology/Oncology/BMT at the University of Colorado, the resources of the University of Colorado Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS) (D&I Science Program, Qualitative & Mixed Methods Research Core). The clinical trial will occur through the 1) Children’s Hospital Colorado (CHCO) HOPE Survivorship Program; CHCO Neuro-Oncology group; and 3) Seattle Children’s Hospital Cancer Survivorship Program. This multiclinic design will ensure successful recruitment as well as increase generalizability of findings. Impact: The proposed study will serve as a necessary first step in improving screening, detection, and treatment of SD in AYA-CCS; future work will include establishing broader effectiveness our screening approach through a multicenter randomized trial, as well as development, testing, and dissemination of multidisciplinary interventions for SD in this population.

项目摘要/摘要 背景：据估计，多达50%的儿童癌症幸存者(CCS)会发生性功能障碍(SD) 对生活质量和心理健康有重要影响。AYA-CCS对SD的有效管理 由于在癌症生存环境中缺乏SD的筛查和检测，这一点基本上是有限的。青少年和 青壮年CCS(Aya-CCS)可能特别容易受到SD及其认知不足的影响，原因是 发展方面的挑战。这项研究解决了这一关键障碍，并作为进展的第一步 为了通过改进筛查来改善Aya CCS中与健康相关的生活质量的长期目标， CCS对SD的认识和治疗。候选人：拟议的奖项将使候选人Dr。 Sopfe，培养必要的技能，以迈向她作为一名独立研究人员的职业生涯 高质量、务实的试验。培训：具体地说，索普夫博士将获得传播和实施方面的经验 (D&I)科学、实用的临床试验和混合方法，这将推动她走向目标明确的研究生涯 制定和传播干预措施，以提高社区卫生服务人员的生活质量。除了体验式培训 通过这项研究计划，索普夫博士将受益于一个多学科的导师团队：主要导师，Dr。 Peterson(杂交试验、定性研究、患者报告的结果)；联合导师，周医生(儿童癌症 生存，临床试验)和方法导师，斯图茨博士(D&I，混合方法)。索普夫博士的训练计划 包括正式的教学课程、研讨会和职业发展计划。研究计划：这 提案的总体目标是使用患者和提供者利益相关者的意见来改进和测试SD的方法 在临床环境中对Aya CCS进行筛查。在D&I框架的指导下，本研究提案将混合使用 方法和迭代测试和修改，以完善SD筛查方法(目标1)。这一方法将 然后在试点类型1混合有效性-实施研究(目标2和3)中进行测试，采用混合 评估患者和提供者结果的方法。环境：这个项目的环境非常特殊 在科罗拉多大学拥有强大的儿科血液学/肿瘤学/骨髓移植学术部门， 科罗拉多大学成人和儿童健康结果研究和交付联盟的资源 科学(ACCODS)(D&I科学计划，定性和混合方法研究核心)。临床试验将 通过科罗拉多州儿童医院(CHCO)希望生存计划；CHCO神经肿瘤学 3)西雅图儿童医院癌症生存计划。这种多诊所的设计将确保 成功招聘以及增加调查结果的概括性。影响：拟议的研究将作为 在Aya-CCS中改进SD的筛查、检测和治疗的必要的第一步；未来的工作将包括 通过多中心随机试验建立更广泛的有效性我们的筛选方法，以及 在这一人群中开发、测试和传播多学科干预措施。