Research Training in Pediatric Oncology

项目摘要/摘要 这是儿科肿瘤学培训资助的竞争性续签申请。此T32的目标是 该计划旨在培养将成为基础和/或临床儿科领域未来学术领袖的医生 肿瘤学研究以及世卫组织将致力于减轻儿科人口中的癌症负担。要完成 为了实现这一目标，我们聘请了一支多样化和杰出的培训人员队伍，他们涵盖了基本的多个领域 (“湿板凳”)、翻译和临床研究。这个经验丰富且高度成功的团队包括 丹纳-法伯癌症研究所(DFCI)儿科肿瘤学系成员 波士顿儿童医院(BCH)的儿科血液学/肿瘤学以及 哈佛医学院(HMS)。在选拔中，特别强调对受训人员的密切指导 以及在他们的研究过程中的持续监督。T32计划提供肿瘤学方面的培训 从DFCI-BCH儿科联合中心挑选的8名学员的博士后水平研究 血液学/肿瘤学奖学金计划，他们正在接受第二年、第三年和第四年的培训。这些 研究员平均在受保护的培训环境中度过五到六年，临床时间有限 拟议的T32延期将继续为三年的培训提供支持。这个 该计划致力于确定和支持最有前途的研究员，包括少数族裔候选人。 在过去的45年里，DFCI-BCH奖学金计划已经培训了200多人，其中许多人是 学术儿科血液学/肿瘤学项目负责人。持续的T32支持将确保培训 他们的研究将极大地有助于理解和 儿童癌症的管理。

PROJECT SUMMARY/ABSTRACT This is a competitive renewal application for training grant support in pediatric oncology. The goal of this T32 program is to train physicians who will be the future academic leaders in basic and/or clinical pediatric oncology research and who will work to reduce the burden of cancer in the pediatric population. To accomplish this goal we have engaged a diverse and outstanding training faculty that embraces multiple areas of basic (“wet bench”), translational and clinical research. This experienced and highly accomplished group includes members of the Department of Pediatric Oncology at the Dana-Farber Cancer Institute (DFCI), the Division of Pediatric Hematology/Oncology at Boston Children's Hospital (BCH), and additional components of the Harvard Medical School (HMS). Particular emphasis is placed on close mentorship of trainees in the selection of mentors and in on-going oversight during their research. The T32 program provides training in oncology research at the postdoctoral level for 8 trainees, selected from the combined DFCI-BCH pediatric hematology/oncology fellowship program, who are in their second, third and fourth years of training. These fellows spend on average five to six years in a protected training environment with limited clinical responsibilities, and the proposed T32 renewal would continue to support three years of that training. The program is committed to identifying and supporting the most promising fellows, including minority candidates. Over the past 45 years the DFCI-BCH fellowship program has trained over 200 individuals, many of whom are leaders of academic pediatric hematology/oncology programs. Continued T32 support will ensure the training of investigational pediatric oncologists, whose research will contribute immeasurably to the understanding and management of childhood cancers.