The Center for Therapeutic Targeting of EWS-oncoproteins
EWS癌蛋白治疗靶向中心
基本信息
- 批准号:10671815
- 负责人:
- 金额:$ 50.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-07 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AwardBasic ScienceBiologyChemicalsChimeric ProteinsClinicClinical ResearchComplexComputational BiologyDevelopmentDiseaseEWS-FLI1 fusion proteinEpigenetic ProcessEwings sarcomaFunctional disorderGenetic TranscriptionGoalsIndividualIndustrializationInstitutionInvestigational TherapiesKnowledgeMalignant NeoplasmsMolecularOncogenicOncoproteinsParentsPediatric OncologistProcessProteinsResearchTalentsTechnologyTherapeuticTherapeutic Clinical TrialTranslationsValidationboneclinical translationdrug developmentimproved outcomemouse modelnovelnovel therapeuticspediatric patientspre-clinicalsarcomaskillsstructural biologysuccesstherapeutic targettooltranslational scientisttumorigenesis
项目摘要
PROJECT SUMMARY: Overall
This section is unchanged from the U54 CA231637 parent award
The primary scientific focus of this Center is to understand the molecular underpinnings of EWS-ETS driven
Ewing sarcoma and to investigate novel treatments and therapeutic mechanisms to improve outcomes for
pediatric patients with this aggressive disease. Translation of molecular understanding of sarcoma
pathophysiology into effective new drugs in the clinic is a complex, risky proposition that requires the
coordinated efforts of a talented team of individuals with complementary skills. This group brings expertise in
Ewing sarcoma biology and the EWS-ETS oncoproteins, epigenetics and transcription, structural biology,
computational biology, chemical biology and drug development, mouse models, preclinical experimental
therapeutics, and clinical trials development. A Center mechanism is essential to the success of this proposal.
No one institution nor individual can bring mastery of the diversity of approaches, technologies, and scientific
domains needed to achieve the goals of this proposal. We have elected to focus on understanding the
fundamental inner workings of Ewing sarcoma from its transcriptional circuits, to the direct protein interactions
with EWS-FLI1, to the direct and immediate effects of EWS-FLI1 degradation. Moreover, a strong emphasis
of this proposal is on target identification and preclinical validation, critical steps in the process of bringing
forward therapies with optimal chances for success in the clinic. The team that is assembled has all of the
component pieces needed for success. Our Center includes outstanding basic cancer biologists, chemists,
computational biologists, and translational researchers, and five pediatric oncologists. Thus, the proposed
Center can catalyze basic discovery and clinical translation by leveraging basic and clinical research talent
within the Center and our strong ties to outside academic and industrial partners.
项目总结:总体
本节与U 54 CA 231637母公司奖励相同
该中心的主要科学重点是了解EWS-ETS驱动的分子基础
尤文肉瘤,并研究新的治疗方法和治疗机制,以改善预后,
患有这种侵袭性疾病的儿科患者。肉瘤的分子理解翻译
将病理生理学转化为临床上有效的新药是一个复杂的、有风险的命题,
一个由具有互补技能的人才组成的团队的协调努力。该小组将专业知识
尤文肉瘤生物学和EWS-ETS癌蛋白,表观遗传学和转录,结构生物学,
计算生物学,化学生物学和药物开发,小鼠模型,临床前实验
治疗和临床试验开发。一个中心的机制对这项建议的成功至关重要。
没有一个机构或个人能够掌握方法、技术和科学的多样性,
实现本提案目标所需的领域。我们选择把重点放在理解
尤文肉瘤的基本内部运作,从转录电路到直接的蛋白质相互作用,
与EWS-FLI 1,EWS-FLI 1降解的直接和立即的影响。此外,强烈强调
该提案的重点是目标识别和临床前验证,这是将
在临床上具有最佳成功机会的前瞻性疗法。集合的团队拥有所有
成功所需的组成部分。我们的中心包括杰出的基础癌症生物学家,化学家,
计算生物学家、翻译研究人员和五名儿科肿瘤学家。因此,拟议的
中心可以通过利用基础和临床研究人才来促进基础发现和临床转化
中心内部以及我们与外部学术和工业合作伙伴的紧密联系。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('SCOTT A ARMSTRONG', 18)}}的其他基金
The Center for Therapeutic Targeting of EWS-oncoproteins
EWS癌蛋白治疗靶向中心
- 批准号:
10382013 - 财政年份:2021
- 资助金额:
$ 50.54万 - 项目类别:
Defining epigenetic mechanisms in NPM1c mutant leukemia
定义 NPM1c 突变白血病的表观遗传机制
- 批准号:
10184546 - 财政年份:2021
- 资助金额:
$ 50.54万 - 项目类别:
Defining epigenetic mechanisms in NPM1c mutant leukemia
定义 NPM1c 突变白血病的表观遗传机制
- 批准号:
10640846 - 财政年份:2021
- 资助金额:
$ 50.54万 - 项目类别:
Defining epigenetic mechanisms in NPM1c mutant leukemia
定义 NPM1c 突变白血病的表观遗传机制
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10388249 - 财政年份:2021
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Targeting DOT1L for Degradation in MLL-rearranged Leukemia
靶向 DOT1L 降解 MLL 重排白血病
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10411945 - 财政年份:2012
- 资助金额:
$ 50.54万 - 项目类别:
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