H2A Admin Core

H2A 管理核心

• 批准号: 10471412
• 负责人: Gregory D Kirk
• 金额: $ 22.14万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-09 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471412
• 关键词: Accounting; Advocate; Africa; Africa South of the Sahara; African; Age; Biological Specimen Banks; Cell Nucleus; Clinical; Collaborations; Communication; Communities; Computer software; Country; Data Collection; Database Management Systems; Development; Documentation; Electronic Mail; Ensure; Face; Generations; Goals; Grant; HIV; Hepatitis B; Hepatitis B Virus; Hepatitis C virus; Human; Infection; Intercept; International; Interruption; Lead; Leadership; Link; Malignant Neoplasms; Medical; Mentors; Monitor; Online Systems; Patient Recruitments; Patients; Peer Review; Periodicity; Policies; Preparation; Primary carcinoma of the liver cells; Problem Solving; Progress Reports; Public Relations; Publications; Reporting; Research; Research Personnel; Resources; Review Literature; Risk Factors; Role; Schistosoma mansonii infection; Senegal; Site; Structure; Supervision; Time; Training; Uganda; Universities; Work; chronic infection; data harmonization; data sharing; expectation; human subject protection; meetings; organizational structure; participant retention; programs; symposium; web site

Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the HCC burden may increase. In prior studies, our team identified chronic infection with hepatitis B and C viruses (HBV, HCV), HIV and Schistosomiasis mansoni as independent risk factors for HCC. Compared to the US, HCC in sub-Saharan Africa occurs at younger age and more advanced stage with survival of only months. Proposed is an East and West African partnership between colleagues at Makerere University in Uganda, Fann University in Senegal and Johns Hopkins University focused on HIV and hepatocellular carcinoma (HCC) in Africa: The H2A Consortium. Building on long-standing collaborative research, mentoring and clinical activities in both countries, our overarching goal is to reduce the heavy burden of HCC in sub- Saharan Africa. We advocate investigating cancer interception strategies using appropriate medical treatments to interrupt or reverse the impact of these HCC-causing infections. The Administrative and Coordinating Core (ACC) will provide overall leadership for implementing the scientific agenda of the H2A consortium. Using best practices from decades of international research collaboration, the H2A Consortium proposes an effective organizational structure and strong leadership with a track record of international research collaboration. The organizational framework builds upon the ongoing close working relationship between prior co-PIs from Uganda and Hopkins and welcomes the Senegalese team as equal partners. The ACC will establish transparent structures to support rigorous study oversight, effective communication, and efficient problem- solving. The H2A Consortium effectively integrates ACC activities within a closely interacting Steering Committee (SC) comprised of the Overall Co-Leaders and the Project /Core PIs. For each Project or Core, the leadership represents an equitable partnership with PIs from each site sharing responsibilities. This leadership nucleus is further supported by an External Advisory Panel (EAP) and a Community Advisory Panel (CAP), with collaborative links to NCI Program leadership and other U54 Consortia sites. The impact of our integrated research and capacity development activities will be establishment of the H2A Consortium as partnered Centers of Excellence on HIV and HCC in East and West Africa.

肝细胞癌（HCC）是非洲非常普遍且致命的癌症，随着HIV患者的活力 更长的时间，HCC负担可能会增加。在先前的研究中，我们的团队确定了乙型肝炎的慢性感染 和C病毒（HBV，HCV），HIV和血吸虫病Mansoni作为HCC的独立危险因素。比较的 对于美国，撒哈拉以南非洲的HCC发生在年轻时，而更高级的阶段仅生存 月份。拟议的是Makerere University的同事之间的东非和西非伙伴关系 乌干达，塞内加尔的范恩大学和约翰·霍普金斯大学专注于艾滋病毒和肝细胞 非洲癌（HCC）：H2A财团。在长期合作研究的基础上进行指导 在两国的临床活动中，我们的总体目标是减轻hcc的沉重负担 撒哈拉非洲。我们主张使用适当的医疗治疗调查癌症截获策略 中断或扭转这些引起HCC引起的感染的影响。行政和协调 Core（ACC）将为实施H2A财团的科学议程提供总体领导。使用 数十年来国际研究合作的最佳实践，H2A财团提出了有效的 组织结构和强大的领导力，并具有国际研究合作的记录。这 组织框架建立在先前的co派之间正在进行的紧密工作关系的基础上 乌干达和霍普金斯并欢迎塞内加尔队成为平等伙伴。 ACC将建立 透明结构以支持严格的学习监督，有效的沟通和有效的问题 - 解决。 H2A联盟有效地将ACC活动集成到紧密相互作用的转向中 委员会（SC）由整个共同领导者和项目 /核心PI组成。对于每个项目或核心， 领导力代表着与每个网站共同责任的PIS公平合作伙伴关系。这个领导 外部咨询小组（EAP）和社区咨询小组（CAP）进一步支持了核。 通过与NCI计划领导力和其他U54联盟网站的协作链接。我们整合的影响 研究和能力开发活动将建立H2A财团 东非和西非的艾滋病毒和HCC卓越中心。