H2A Admin Core

H2A 管理核心

• 批准号: 10471412
• 负责人: Gregory D Kirk
• 金额: $ 22.14万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-09 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471412
• 关键词: Accounting; Advocate; Africa; Africa South of the Sahara; African; Age; Biological Specimen Banks; Cell Nucleus; Clinical; Collaborations; Communication; Communities; Computer software; Country; Data Collection; Database Management Systems; Development; Documentation; Electronic Mail; Ensure; Face; Generations; Goals; Grant; HIV; Hepatitis B; Hepatitis B Virus; Hepatitis C virus; Human; Infection; Intercept; International; Interruption; Lead; Leadership; Link; Malignant Neoplasms; Medical; Mentors; Monitor; Online Systems; Patient Recruitments; Patients; Peer Review; Periodicity; Policies; Preparation; Primary carcinoma of the liver cells; Problem Solving; Progress Reports; Public Relations; Publications; Reporting; Research; Research Personnel; Resources; Review Literature; Risk Factors; Role; Schistosoma mansonii infection; Senegal; Site; Structure; Supervision; Time; Training; Uganda; Universities; Work; chronic infection; data harmonization; data sharing; expectation; human subject protection; meetings; organizational structure; participant retention; programs; symposium; web site

Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the HCC burden may increase. In prior studies, our team identified chronic infection with hepatitis B and C viruses (HBV, HCV), HIV and Schistosomiasis mansoni as independent risk factors for HCC. Compared to the US, HCC in sub-Saharan Africa occurs at younger age and more advanced stage with survival of only months. Proposed is an East and West African partnership between colleagues at Makerere University in Uganda, Fann University in Senegal and Johns Hopkins University focused on HIV and hepatocellular carcinoma (HCC) in Africa: The H2A Consortium. Building on long-standing collaborative research, mentoring and clinical activities in both countries, our overarching goal is to reduce the heavy burden of HCC in sub- Saharan Africa. We advocate investigating cancer interception strategies using appropriate medical treatments to interrupt or reverse the impact of these HCC-causing infections. The Administrative and Coordinating Core (ACC) will provide overall leadership for implementing the scientific agenda of the H2A consortium. Using best practices from decades of international research collaboration, the H2A Consortium proposes an effective organizational structure and strong leadership with a track record of international research collaboration. The organizational framework builds upon the ongoing close working relationship between prior co-PIs from Uganda and Hopkins and welcomes the Senegalese team as equal partners. The ACC will establish transparent structures to support rigorous study oversight, effective communication, and efficient problem- solving. The H2A Consortium effectively integrates ACC activities within a closely interacting Steering Committee (SC) comprised of the Overall Co-Leaders and the Project /Core PIs. For each Project or Core, the leadership represents an equitable partnership with PIs from each site sharing responsibilities. This leadership nucleus is further supported by an External Advisory Panel (EAP) and a Community Advisory Panel (CAP), with collaborative links to NCI Program leadership and other U54 Consortia sites. The impact of our integrated research and capacity development activities will be establishment of the H2A Consortium as partnered Centers of Excellence on HIV and HCC in East and West Africa.

肝细胞癌在非洲是一种非常常见和致命的癌症，作为艾滋病毒携带者的患者生活在非洲。 时间长了，肝细胞癌的负担可能会增加。在之前的研究中，我们的团队确认了慢性乙肝感染 C病毒(乙肝病毒、丙型肝炎病毒)、HIV和曼氏血吸虫病是肝细胞癌的独立危险因素。相比较 对美国来说，撒哈拉以南非洲的肝癌发生在较年轻和较晚期的患者中，仅 月份。Makerere大学的同事们提议在东非和西非建立伙伴关系 乌干达、塞内加尔范恩大学和约翰霍普金斯大学专注于艾滋病毒和肝细胞 非洲的癌症(肝癌)：H_2A联盟。建立在长期合作研究、指导的基础上 和临床活动，我们的首要目标是减轻亚洲区的肝癌负担 撒哈拉非洲。我们主张使用适当的医疗手段研究癌症拦截策略。 以阻断或逆转这些引起肝癌的感染的影响。管理与协调 CORE(行政协调会)将为执行H_2A财团的科学议程提供全面领导。vbl.使用 来自数十年国际研究合作的最佳实践，H2 A联盟提出了一种有效的 组织结构和强大的领导力，具有国际研究合作的记录。这个 组织框架建立在以前的合作绩效指标之间持续密切的工作关系基础上 乌干达和霍普金斯大学，并欢迎塞内加尔团队作为平等伙伴。行政协调委员会将建立 透明的结构，支持严格的研究监督、有效的沟通和高效的问题- 解决问题。H_2A联盟有效地将行政协调委员会的活动整合到密切互动的指导中 由总体共同领导和项目/核心绩效指标组成的委员会(SC)。对于每个项目或核心， 领导力代表着与每个站点的PI建立公平的伙伴关系，共同承担责任。这个领导层 中心还得到了一个外部咨询小组和一个社区咨询小组的支持， 与NCI计划领导力和其他U54联盟站点的协作链接。我们一体化的影响 研究和能力发展活动将作为合作伙伴建立氢氧化氢财团 东非和西非艾滋病毒和肝癌英才中心。