H2A Developmental Core

H2A 发展核心

• 批准号: 10471414
• 负责人: Gregory D Kirk
• 金额: $ 5.71万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-09 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471414
• 关键词: Advocate; Africa; Africa South of the Sahara; African; Age; Award; Career Mobility; Clinical; Clinical Research; Collaborations; Complement; Country; Development; Fostering; Funding; Goals; HIV; Hepatitis B; Hepatitis B Virus; Hepatitis C virus; Individual; Infection; Intercept; Interruption; Investments; Lead; Link; Malignant Neoplasms; Malignant neoplasm of liver; Medical; Mentors; Mentorship; Mission; Patients; Peer Review; Pilot Projects; Play; Primary carcinoma of the liver cells; Process; Publications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Schistosoma mansonii infection; Senegal; Talents; Training Activity; Training Programs; Uganda; Universities; anticancer research; base; career; career development; chronic infection; design; faculty mentor; global health; innovation; next generation; peer; programs; recruit; senior faculty; skills; success

Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the HCC burden may increase. In prior studies, our team identified chronic infection with hepatitis B and C viruses (HBV, HCV), HIV and Schistosomiasis mansoni as independent risk factors for HCC. Compared to the US, HCC in sub-Saharan Africa occurs at younger age and more advanced stage with survival of only months. Proposed is an East and West African partnership between colleagues at Makerere University in Uganda, Fann University in Senegal and Johns Hopkins University focused on HIV and hepatocellular carcinoma (HCC) in Africa: The H2A Consortium. Building on long-standing collaborative research, mentoring and clinical activities in both countries, our overarching goal is to reduce the heavy burden of HCC in sub- Saharan Africa. We advocate investigating cancer interception strategies using appropriate medical treatments to interrupt or reverse the impact of these HCC-causing infections. We will accomplish this objective by developing local capacity and performing important research. The H2A Scholar Award provides synergistic funding to early-stage African investigators for both individual career development activities and a mentored pilot project utilizing the substantive Consortium resources. Designation of Scholars will alternate yearly between Uganda and Senegal and opportunities to link across countries and with Hopkins will actively be pursued. Our approach of providing early-stage African investigators with substantive pilot project resources and pairing them with a Hopkins mentor will maximize the return on investment. The ultimate goal is to develop a cadre of talented, qualified African investigators to serve as leaders in the field of HIV and HCC research.

肝细胞癌（HCC）是非洲非常普遍且致命的癌症，随着HIV患者的活力 更长的时间，HCC负担可能会增加。在先前的研究中，我们的团队确定了乙型肝炎的慢性感染 和C病毒（HBV，HCV），HIV和血吸虫病Mansoni作为HCC的独立危险因素。比较的 对于美国，撒哈拉以南非洲的HCC发生在年轻时，而更高级的阶段仅生存 月份。拟议的是Makerere University的同事之间的东非和西非伙伴关系 乌干达，塞内加尔的范恩大学和约翰·霍普金斯大学专注于艾滋病毒和肝细胞 非洲癌（HCC）：H2A财团。在长期合作研究的基础上进行指导 在两国的临床活动中，我们的总体目标是减轻hcc的沉重负担 撒哈拉非洲。我们主张使用适当的医疗治疗调查癌症截获策略 中断或扭转这些引起HCC引起的感染的影响。我们将通过 发展当地能力并进行重要研究。 H2A学者奖提供协同作用 为非洲早期调查人员提供个人职业发展活动和一项指导的资金 利用实质财团资源的试点项目。学者的名称将每年交替 在乌干达和塞内加尔之间以及与跨国之间以及与霍普金斯之间建立联系的机会将积极地成为 追捕。我们为早期非洲调查人员提供实质性试点项目资源的方法 将它们与霍普金斯的导师配对将最大化投资回报率。最终目标是发展 一群才华横溢，合格的非洲调查人员担任艾滋病毒和HCC研究领域的领导者。