Core A: Administrative Core

摘要 行政核心的主要目标是通过促进连贯性来确保方案的生产力 PIs及其实验室成员之间的协同以及智力和资源共享，以确保 在每个项目中进行的研究的结果和价值大于其部分的总和。这 CORE将促进和协调以下对整个计划的成功至关重要的活动： 研究计划和科学审查，监控与计划目标、数据相关的进展 交换、试剂和动物/组织共享，参加年度计划会议和PI实验室之间的旅行，以及 报告和财政监督。因此，核心A将提供实现最大化所需的结构和组织 三个研究项目(核心B)中的个人助理和实验室成员之间的互动和协作 和核心C，这将反过来促进计划目标的实现。 根据过去的经验，我们认为有效合作的关键是直接的个人互动。 五个实验室中有三个位于奥斯汀地区。曼利博士的团队在佐治亚大学。黑尔博士和 桑波斯基在杜克大学。正如曼利博士和里奇博士在一起工作了近20年所知道的那样，旅行 雅典和奥斯汀之间的航班相对便宜，每天都有多个直达航班。 同样，从罗利/达勒姆到奥斯汀的旅行也很简单。人员在实验室之间的旅行更方便 实现科学目标，在某些情况下是拟议的实验所必需的。实验室成员 交流是实验室间技术转移的最有效机制。所有三个研究项目 将交换实验室成员以实现特定的科学目标。出差参加年度计划实验室峰会 科学会议为彼此和科学界提供了有效的成果交流， 并提供学习新方法和获得信息以塑造未来工作的能力。此外，这也是一种高效的 为所有实验室成员提供了一种有效的方式，让他们一起开会讨论数据。虽然面对面的会议是一种 宝贵的通信方法，在地理分布的协作中，它们必然是有限的 在范围内。我们已经参与并将继续进行基于Web的会议，允许多站点可视和 音频通信，并便于协作分析数据和图像。 一般行政职能将提供至关重要的额外凝聚力和促进方案 生产力。虽然大部分与行政助理相关的支持将继续由家庭提供 每个PI、核心A的机构将执行需要在研究之间进行协调的任何此类服务 项目和核心。

Summary The primary goal of the Administrative Core is to ensure productivity of the Program by promoting coherence and synergy as well as intellectual and resource sharing, among the PIs and their lab members in order to ensure that the outcome and value of the research performed in each Project is greater than the sum of its parts. This Core will facilitate and coordinate the following activities that are essential for the success of the entire Program: research planning and scientific review, monitoring progress relative the proposed Program goals, data exchange, reagent and animal/tissue sharing, travel to annual Program meetings and between PI labs, and reporting and fiscal oversight. Thus, Core A will provide the structure and organization needed to maximize interactions and collaboration among the PIs and lab members in each of the three Research Projects, Core B and Core C, which will, in turn, facilitate accomplishment of Program goals. Based on past experience, we believe that the key to effective collaboration is direct personal interactions. Three of the five labs are in the Austin area. Dr. Manley’s group is at the University of Georgia. Drs. Hale and Sempowski are at Duke. As Drs. Manley and Richie know from working together for nearly 20 years, travel between Athens and Austin is relatively inexpensive with multiple direct flights available on a daily basis. Similarly, traveling from Raleigh/Durham to Austin is straightforward. Personnel travel between labs facilitates achieving scientific objectives, and is in some cases necessary for the proposed experiments. Lab member exchange is the most effective mechanism for transfer of techniques between labs. All three Research Projects will exchange lab members to achieve specific scientific goals. Travel to annual Program lab summits and scientific meetings provides for efficient communication of results to each other and to the scientific community, and affords the ability to learn new approaches and gain information to shape future work. Also, this is an efficient and effective way for all lab members to meet and discuss data together. While face-to-face meetings are an invaluable method of communication, in a geographically distributed collaboration they are of necessity limited in scope. We are already engaged in and will continue web-based conferencing that permits multi-site visual and audio communication, and facilitates analyzing data and images collaboratively. General administrative functions will provide vital additional levels of cohesion and facilitate program productivity. While most administrative assistant related support will continue to be supplied by the home institutions of each PI, Core A will perform any such services requiring coordination between the Research Projects and Cores.