The Role of Airway Morphology in Environmental LungDiseases

项目摘要/摘要 候选人：Coralynn Sack医学博士，公共卫生硕士，计划在 环境肺病领域。这个奖项的目的是提供必要的 支持和培训，以帮助她向独立调查员过渡。萨克医生已经 组建了一个由乔尔·考夫曼博士领导的跨学科导师团队，他们都是空气方面的专家 污染流行病学、毒理学、先进成像、呼吸道特征、生物统计学和 翻译科学-她希望在此期间进一步发展和完善的技能 获奖。通过纳入正式课程、个性化技术培训和保护 在有组织的学习计划中研究时间，她处于理想的位置，可以做出重大贡献 我们对空气污染对肺部健康影响的理解。 研究：接触环境物质是慢性肺部疾病的主要原因 全球死亡率。呼吸道形态可能是疾病病理生物学的重要决定因素 通过改变沉积位置和环境暴露的内在化剂量。这 提案包含一套主题集成的流行病学和转译研究， 寻求阐明呼吸道在环境肺疾病中的作用。该计划的目标 计划中的研究包括：1)确定呼吸道特征是否会改变这种联系 空气污染和慢性阻塞性肺病在基于人群的队列和患有 COPD；2)使用实验小鼠模型研究所提出的机制途径。 这项建议中的工作检验了一个与易感性有关的新的和重要的假说 可能会对公众健康产生重大影响的环境因素。 环境：华盛顿大学是萨克博士进行研究培训的理想场所。 威斯康星州大学现有的资源和设施非常适合成功完成 该项目将空气污染流行病学研究的卓越成果与最先进的技术相结合 基于实验室的研究。威斯康星大学的研究环境非常出色，拥有强大的 致力于促进初级调查人员的学术生涯。有一个很长的， 出版了该大学与萨克博士合作者之间成功合作的历史 在外部机构。萨克博士将得到全国著名的威斯康星大学 公共卫生、医学部、肺部、重症监护和睡眠科 医学和环境与职业健康科学部。

PROJECT SUMMARY/ ABSTRACT Candidate: Coralynn Sack MD, MPH, plans for a career as a translational clinician scientist in the field of environmental lung diseases. The purpose of this award is to provide the essential support and training to help facilitate her transition to an independent investigator. Dr. Sack has assembled a team of inter-disciplinary mentors, led by Dr. Joel Kaufman, who are experts in air pollution epidemiology, toxicology, advanced imaging, airway characterization, biostatistics and translational science – skills that she hopes to further develop and refine during this proposed award. By incorporating formal coursework, personalized technical training and protected research time in a structured learning plan, she is ideally positioned to contribute substantially to our understanding of the impact of air pollution on lung health. Research: Exposure to environmental agents is a leading cause of chronic lung diseases and global mortality. Airway morphology may be an important determinant of disease pathobiology by modifying the site of deposition and internalized dose of environmental exposures. This proposal contains a thematically integrated set of epidemiologic and translational studies that seek to elucidate the role of the airway in environmental lung diseases. The objectives of the planned research include: 1) to determine whether airway characteristics modify the association between air pollution and COPD in a population based cohort and a cohort of individuals with COPD; 2) investigate the proposed mechanistic pathway using an experimental murine model. The work in this proposal examines a novel and important hypothesis related to susceptibility to environmental agents that could have significant public health implications. Environment: The University of Washington is an ideal setting for Dr. Sack’s research training. The resources and facilities available at UW are uniquely suited to the successful completion of this project, combining excellence in epidemiologic studies on air pollution with state-of-the art laboratory-based research. The research environment at UW is outstanding, with a strong commitment to furthering the academic careers of junior investigators. There is a long, published history of successful partnerships between the University and Dr. Sack’s collaborators at outside institutions. Dr. Sack will have support from the nationally renowned UW School of Public Health, the Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, and the Department of Environmental and Occupational Health Sciences.