The Role of Airway Morphology in Environmental LungDiseases

气道形态在环境性肺疾病中的作用

• 批准号: 10006007
• 负责人: Coralynn Shayna Sack
• 金额: $ 16.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006007
• 关键词: Acute; Adverse effects; Affect; Air Pollution; Alveolar Macrophages; Award; Biometry; Caliber; Carbon Black; Characteristics; Chronic Obstructive Airway Disease; Chronic lung disease; Cohort Studies; Critical Care; Data Sources; Deposition; Developed Countries; Development; Diesel Exhaust; Disease; Disease Progression; Dose; Enrollment; Environment; Environmental Exposure; Environmental Health; Epidemiology; Exposure to; FGF10 gene; Genes; Geographic Locations; Geometry; Health; Health Sciences; Human; Image; Individual; Induced Mutation; Inhalation; Institution; Laboratories; Lead; Learning; Literature; Long-Term Effects; Lung; Lung diseases; Measurement; Measures; Medicine; Mentors; Modeling; Morphology; Multi-Ethnic Study of Atherosclerosis; Mus; Occupational Health; Outcome Measure; Participant; Pathogenesis; Pathway interactions; Pattern; Play; Pollution; Positioning Attribute; Predisposition; Prevalence; Public Health; Public Health Schools; Publishing; Pulmonary Emphysema; Recording of previous events; Research; Research Personnel; Research Training; Resources; Respiratory Signs and Symptoms; Respiratory physiology; Risk Factors; Role; Scientist; Site; Sleep; Smoking; Spirometry; Structure; Structure of parenchyma of lung; Testing; Time; Toxicology; Training; Translational Research; Universities; Variant; Washington; Work; X-Ray Computed Tomography; base; career; career development; cohort; environmental agent; epidemiology study; experience; mortality; mouse model; novel; particle; pollutant; population based; response; skills; translational physician; translational study; uptake

PROJECT SUMMARY/ ABSTRACT Candidate: Coralynn Sack MD, MPH, plans for a career as a translational clinician scientist in the field of environmental lung diseases. The purpose of this award is to provide the essential support and training to help facilitate her transition to an independent investigator. Dr. Sack has assembled a team of inter-disciplinary mentors, led by Dr. Joel Kaufman, who are experts in air pollution epidemiology, toxicology, advanced imaging, airway characterization, biostatistics and translational science – skills that she hopes to further develop and refine during this proposed award. By incorporating formal coursework, personalized technical training and protected research time in a structured learning plan, she is ideally positioned to contribute substantially to our understanding of the impact of air pollution on lung health. Research: Exposure to environmental agents is a leading cause of chronic lung diseases and global mortality. Airway morphology may be an important determinant of disease pathobiology by modifying the site of deposition and internalized dose of environmental exposures. This proposal contains a thematically integrated set of epidemiologic and translational studies that seek to elucidate the role of the airway in environmental lung diseases. The objectives of the planned research include: 1) to determine whether airway characteristics modify the association between air pollution and COPD in a population based cohort and a cohort of individuals with COPD; 2) investigate the proposed mechanistic pathway using an experimental murine model. The work in this proposal examines a novel and important hypothesis related to susceptibility to environmental agents that could have significant public health implications. Environment: The University of Washington is an ideal setting for Dr. Sack’s research training. The resources and facilities available at UW are uniquely suited to the successful completion of this project, combining excellence in epidemiologic studies on air pollution with state-of-the art laboratory-based research. The research environment at UW is outstanding, with a strong commitment to furthering the academic careers of junior investigators. There is a long, published history of successful partnerships between the University and Dr. Sack’s collaborators at outside institutions. Dr. Sack will have support from the nationally renowned UW School of Public Health, the Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, and the Department of Environmental and Occupational Health Sciences.

项目总结/摘要 候选人：Coralynn Sack医学博士，公共卫生硕士，计划作为一名翻译临床科学家的职业生涯， 环境性肺病领域。该奖项的目的是提供必要的 支持和培训，以帮助她过渡到独立调查员。萨克医生 组建了一个跨学科的导师团队，由乔尔考夫曼博士领导，他们是空气专家 污染流行病学，毒理学，先进的成像，气道表征，生物统计学和 翻译科学-技能，她希望进一步发展和完善，在此期间提出的 奖通过整合正式的课程、个性化的技术培训， 研究时间在结构化的学习计划，她是理想的定位，以作出重大贡献， 我们对空气污染对肺部健康影响的认识。 研究：暴露于环境因素是慢性肺部疾病的主要原因， 全球死亡率。气道形态可能是疾病病理生物学的重要决定因素 通过改变沉积的位置和环境暴露的内在剂量。这 提案包含一套主题整合的流行病学和转化研究， 试图阐明气道在环境性肺部疾病中的作用。的目标 计划的研究包括：1）确定气道特征是否改变了 在基于人群的队列和患有COPD的个体队列中， COPD; 2）使用实验鼠模型研究所提出的机制途径。 这项提案中的工作研究了一个与易感性相关的新的重要假设， 可能对公共卫生产生重大影响的环境因素。 环境：华盛顿大学是Sack博士研究培训的理想场所。 在UW可用的资源和设施是唯一适合成功完成 该项目结合了空气污染流行病学研究的卓越成果和最先进的技术， 基于实验室的研究。在UW的研究环境是杰出的，具有强大的 致力于促进初级研究人员的学术生涯。有一个很长的， 出版的大学和萨克博士的合作者之间的成功伙伴关系的历史 在外面的机构。萨克博士将得到全国知名的华盛顿大学商学院的支持。 公共卫生，内科，肺部，重症监护和睡眠部 医学，以及环境和职业健康科学系。