Probing Event Structure in Children's Naturalistic Memory Using Representational Similarity Analysis of Scalp-Recorded EEG

使用头皮记录脑电图的表征相似性分析探索儿童自然记忆中的事件结构

• 批准号: 10381697
• 负责人: Kerstin Bianca Unger
• 金额: $ 7.7万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381697
• 关键词: 8 year old; Address; Adolescent; Adult; Affect; Age; Brain; Case Study; Child; Childhood; Clinical; Clip; Cognitive; Complex; Data; Decision Making; Detection; Development; Down Syndrome; Educational Intervention; Environment; Epilepsy; Episodic memory; Event; Film; Fragile X Syndrome; Functional Magnetic Resonance Imaging; Future; Human; Impairment; Intervention; Judgment; Knowledge; Laboratories; Life; Literature; Memory; Memory impairment; Mental Depression; Nature; Nervous System Trauma; Neurocognitive; Neurodevelopmental Disorder; Neurologic; Outcome; Pattern; Perception; Personal Satisfaction; Quality of life; Research; Scalp structure; Signal Transduction; Social Interaction; Stimulus; Structure; Testing; Thinking; Time; Traumatic Brain Injury; Validation; Work; base; cognitive training; design; effective intervention; experience; field study; improved; middle childhood; movie; multisensory; neural patterning; neuroimaging; neuromechanism; neuropsychiatry; news; novel; novel strategies; relating to nervous system; stress related disorder; temporal measurement; tool; translational barrier; virtual

PROJECT SUMMARY/ABSTRACT From an early age, episodic memory supports critical functions such as decision-making in the present, future thinking, development of the self, and social interaction. Episodic memory is not only highly vulnerable to neurological insult, impairments are also prevalent in various neurodevelopmental disorders and neuropsychiatric conditions. There are profound negative consequences for later academic outcomes and socioemotional well-being associated with early disruption of episodic memory function but effective interventions in are scarce. Given that structural and functional brain maturation provides key constraints on memory function and their malleability to interventions, the neural basis of episodic memory development has become an increasingly important field of study in recent years. However, pediatric neuroimaging studies that bridge the gap between the highly controlled laboratory environment and real-life memory function are virtually absent, thereby failing to provide guidance for effective interventions. Recent neuroimaging work in adults shows great promise to overcome this limitation by utilizing novel tools to extract neural activity patterns from electroencephaolographic (EEG) and functional magnetic resonance imaging (fMRI) signals elicited during perception and recall of complex, dynamic, and multi-sensory naturalistic events, such as filmed, written, or spoken stories. The overall objective of the proposed project is to validate this new approach for the study of naturalistic memory in the transition from early to middle childhood—an age period that is characterized by rapid improvement in episodic memory function. Fifty 5-8-year-old children will view a 33-min movie clip and then verbally recount its content. Capitalizing on the high temporal resolution of scalp EEG, this study aims to replicate 3 key findings from previous work in adults: (1) Show that continuous experience is divided into discrete events by identifying perceived boundaries between events as rapid shifts in the stability of EEG activity patterns. Representational similarity analyses will be used to compare the stability of children’s brain activity patterns within events vs. across event boundaries. Pattern similarity is predicted to be higher within the same event than across different events. (2) Test whether boundary detection triggers rapid replay of just- encoded events. Event reinstatement upon boundary detection will be quantified by comparing across- boundary similarity for pre-boundary events that are later remembered vs. those that are later forgotten. Relatively greater similarity is expected between pre- and post-boundary EEG patterns if the pre-boundary event is later successfully recalled. (3) Establish to which extent movie viewing and later spoken recall elicit similar patterns of event-specific EEG activity. Viewing-to-recall correlations of EEG patterns should be greater for matching than nonmatching events. This research could aid the design of training interventions that account for constraints on how children perceive, understand, and retrieve events in real-world settings and thus are more likely to generalize to the academic and everyday cognitive domains they are intended to improve.

项目总结/摘要 从很小的时候起，情景记忆就支持着关键的功能，比如现在、未来的决策， 思考、自我发展和社会互动。情景记忆不仅极易受到 神经损伤、损伤也普遍存在于各种神经发育障碍中， 神经精神疾病这对以后的学术成果有着深远的负面影响， 社会情绪健康与情节记忆功能的早期中断有关，但有效 的干预是稀缺的。鉴于大脑结构和功能的成熟提供了关键的限制， 记忆功能及其对干预的可塑性，情景记忆发展的神经基础， 近年来成为一个越来越重要的研究领域。然而，儿科神经影像学研究， 在高度受控的实验室环境和现实生活中的记忆功能之间架起了一座差距的桥梁， 缺席，从而无法为有效的干预措施提供指导。最近的成人神经影像学工作 显示出很大的希望，以克服这一限制，利用新的工具，以提取神经活动模式， 脑电波（EEG）和功能性磁共振成像（fMRI）信号， 感知和回忆复杂的，动态的，多感官的自然主义事件，如电影，书面，或 讲故事拟议项目的总体目标是验证这一新的研究方法， 自然主义记忆在过渡期从早期到中期的童年-一个年龄段的特点是， 情节记忆功能的快速改善。50名5-8岁的儿童将观看一段33分钟的电影片段， 然后口头讲述内容。利用头皮EEG的高时间分辨率，本研究旨在 在成人中重复先前工作的3个关键发现：（1）表明持续的经验分为 通过将事件之间的感知边界识别为EEG稳定性的快速变化， 活动模式。表征相似性分析将用于比较儿童大脑的稳定性 事件内活动模式与跨事件边界活动模式。预测模式相似性在 相同的事件比不同的事件。(2)测试边界检测是否会触发快速重放- 编码事件。边界检测后的事件恢复将通过比较- 边界相似性，用于后来记住的边界前事件与后来忘记的边界前事件。 如果边界前EEG模式与边界后EEG模式之间的相似性相对较大， 事件后来被成功召回。(3)确定看电影和后来的口头回忆在多大程度上引起 事件特异性脑电图活动的相似模式。脑电模式的观看-回忆相关性应该更大 而不是不匹配的事件。这项研究可以帮助设计培训干预措施， 对于儿童如何感知，理解和检索现实世界设置中的事件的限制， 更有可能推广到他们想要改进的学术和日常认知领域。