Echoic Memory Function and Physiology in the Rhesus Macaque

恒河猴的回声记忆功能和生理学

• 批准号: 10382304
• 负责人: Tobias Teichert
• 金额: $ 39.13万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382304
• 关键词: Active Listening; Affect; Animals; Auditory; Auditory area; Behavioral; Benchmarking; Categories; Characteristics; Data; Discrimination; Dissection; Electrodes; Electrophysiology (science); Exhibits; Eye; Glutamates; Homologous Gene; Impairment; Individual; Intervention; Ketamine; Lead; Link; Macaca; Macaca mulatta; Measures; Memory; Memory impairment; Midazolam; Modeling; Molecular; Monkeys; Neurons; Performance; Pharmacology; Physiology; Pitch Discrimination; Positioning Attribute; Primates; Process; Property; Pupil; Randomized; Reading; Refractory; Schizophrenia; Short-Term Memory; Stimulus; Synapses; Testing; Time; Weight; Work; auditory processing; awake; behavior measurement; encephalography; improved; memory encoding; neural correlate; nonhuman primate; novel; prevent; psychosocial; relating to nervous system; response; shared memory; social cognition; sound; synaptic depression; therapy development

7. PROJECT SUMMARY Background. Echoic memory (EM) is a pre-categorical and passive form of auditory short-term memory. EM is essential for processing sounds that are inherently fleeting yet acquire meaning only in relation other sounds. The neural substrate of echoic memory has not bee identified. It is well-established that the processing of a sound temporarily reduces the responsiveness of auditory cortex to similar sounds (refractoriness or stimulus-specific adaptation: R/SSA). It has been noted that R/SSA fade with similar time- constants as information about past sounds fades from EM. The proposed work will test the hypothesis that the cause for the reduced responsiveness that underlies R/SSA is the neural substrate of EM.

7。项目摘要 背景。回声记忆（EM）是听觉短期内存的前类别和被动形式。 em对于处理固有短暂而又获得含义的声音至关重要 听起来。回声记忆的神经底物尚未鉴定出来。众所周知的是 声音的处理暂时降低了听觉皮层对类似声音的响应能力 （折射率或刺激特异性适应：R/SSA）。已经注意到的是，R/SSA的淡出类似的时间 - 作为过去的信息，常数从em淡出。拟议的工作将检验以下假设 R/SSA构成的响应性降低的原因是EM的神经底物。