Administrative Core

U19哮喘和过敏性疾病合作研究中心(AACDRC)项目汇集了 三个互动项目和两个核心的研究团队，专注于特定先天的病理生物学 病毒感染和哮喘的免疫机制。在更新我们的AADCRC计划时，我们将继续 为了关注关键的、通常被忽视的天然免疫因子表面活性蛋白-A(SP-A)， 表面活性剂的阴离子脂(棕榈酰-油酰-磷脂酰甘油(POPG)和磷脂酰肌醇(PI)) 和Toll相互作用蛋白(Tollip)，一种已知与SP-A和 阴离子脂类。这些介质中的每一个都协同作用来调节炎症和免疫。 鉴于哮喘和感染的互补功能，它们的反应。我们激动人心的初步数据支撑着 我们项目的总体假设是POPG/PI、Tollip和SP-A作为独特的免疫调节剂发挥作用 减弱2型中特定病毒感染(RV-C、甲型流感和SARS-CoV-2)的影响 哮喘。该项目的调查人员在该项目中有很长的合作历史。亚利桑那大学和 国家犹太人健康中心；锡达西奈医疗中心现在包括在这次更新中。行政核心 本计划的(核心A)将发挥重要作用，以保持富有成效和活力的协作，确保 并跟踪对NIH和其他相关法规和指南的遵守情况，并管理将 继续加强围绕该计划的研究社区。行政核心具有 以下具体目标：(1)管理日常行政细节和方案需求 AADCRC通过提供财务管理、管理分包合同、确保监管 满足中的要求，并根据计划目标监控进度；(2)创建基础设施以 促进项目、核心和项目之间的沟通。调查人员、NIH项目主任和TO 在必要时提供冲突解决；(3)及时协助传播研究成果 向地方和全国科学界宣传，并向公众提供信息，包括 研究参与者；4)为亚洲及太平洋发展研究中心实施基础设施和机会基金。我们的提案建立了 基于我们20多年来积极和富有成效的合作，并将显著增进我们的理解 2型炎症与病毒相互作用的内在分子机制 哮喘加重。我们项目之间的强大协同作用将加快创新的进展 通过证明研究中的先天免疫成分预防病毒而进行的治疗 哮喘中的感染。

This U19 Asthma and Allergic Diseases Cooperative Research Center (AACDRC) Program brings together a team of investigators in three interactive projects and two cores to focus on the pathobiology of specific innate immune mechanisms in viral infection and asthma. In the renewal of our AADCRC program, we will continue to focus on the critical and often understudied innate immune factors surfactant protein-A (SP-A), the anion lipids of surfactant, (palmitoyl-oleoyl-phosphatidylglycerol (POPG) and phosphatidylinositol (PI)) and Toll interacting protein (Tollip), an innate immune mediator known to cross talk with SP-A and the anionic lipids. Each of these mediators works synergistically to modulate inflammatory and immunologic responses in asthma and infection given their complementary functions. Our exciting preliminary data underpin our program’s overall hypothesis that POPG/PI, Tollip and SP-A function as unique immune modulators that attenuate the impact of specific viral infections (RV-C, Influenza A and SARS-CoV-2) in type-2 asthma. The investigators in this program have a long history of collaboration at the. University of Arizona and National Jewish Health; Cedar Sinai Medical Center is now included in this renewal. The Administrative Core (Core A) of this Program will perform an important role to maintain productive and vibrant collaboration, ensure and track adherence to NIH and other relevant regulations and guidelines, and manage activities that will continue to strengthen the research community surrounding this Program. The Administrative Core has the following Specific Aims: (1) Manage the day-to-day administrative details and programmatic needs of the AADCRC program by providing fiscal management, administering subcontracts, assuring that regulatory requirements in are met, and monitoring of progress with program objectives; (2) Create an infrastructure to facilitate communication between the projects, cores and. investigators, and NIH Program Directors and to provide conflict resolution should it be necessary; (3) Assist with dissemination of research findings in a timely fashion to the scientific community, both locally and nationally, and provide information to the public, including study participants; 4) Implement the Infrastructure and Opportunity Fund for the AADCRC. Our proposal builds upon our active and productive collaborations of over 20 years and will significantly enhance our understanding of the innate molecular mechanisms underlying the interaction between type 2 inflammation in and viral exacerbations of asthma. The strong synergy among our projects will accelerate progress toward novel therapies by demonstrating that the innate immune components under study protect against viral infection in asthma.