Administrative Core

这个U19哮喘和过敏性疾病合作研究中心（AACDRC）计划汇集了 一个研究小组在三个互动项目和两个核心，重点放在特定的先天性 病毒感染和哮喘的免疫机制。在更新我们的AADCRC计划时，我们将继续 为了关注关键的且经常未被充分研究的先天免疫因子表面活性蛋白-A（SP-A）， 表面活性剂阴离子脂质（棕榈酰-油酰-磷脂酰甘油（POPG）和磷脂酰肌醇（PI）） 和Toll相互作用蛋白（Tollip），一种先天免疫介质，已知与SP-A和免疫球蛋白相互作用。 阴离子脂质。这些介质中的每一种协同作用以调节炎症和免疫反应。 哮喘和感染的反应，因为它们的互补功能。我们令人兴奋的初步数据支持 我们项目的总体假设是POPG/PI、Tollip和SP-A作为独特的免疫调节剂发挥作用 减弱特定病毒感染（RV-C、甲型流感和SARS-CoV-2）对2型 哮喘该项目的研究人员在美国有着悠久的合作历史。亚利桑那大学和 国家犹太健康;雪松西奈医疗中心现在包括在这次更新。行政核心 (Core A）本计划将发挥重要作用，以保持富有成效和充满活力的合作，确保 跟踪对NIH和其他相关法规和指南的遵守情况，并管理将 继续加强围绕该计划的研究社区。行政核心具有 （1）管理日常行政细节和方案需要， AADCRC计划通过提供财政管理，管理分包合同，确保监管 （2）建立基础设施， 促进项目、核心和。研究人员和NIH项目主任， 在必要时提供冲突解决办法;（3）协助及时传播研究成果， 时尚的科学界，无论是在地方和国家，并提供信息给公众，包括 研究参与者; 4）为AADCRC实施基础设施和机会基金。我们的建议是 在我们20多年的积极和富有成效的合作，并将大大提高我们的理解 2型炎症和病毒感染之间相互作用的内在分子机制 哮喘恶化。我们的项目之间的强大协同作用将加速向新的进展 通过证明研究中的先天免疫成分可以保护免受病毒感染， 哮喘的感染

This U19 Asthma and Allergic Diseases Cooperative Research Center (AACDRC) Program brings together a team of investigators in three interactive projects and two cores to focus on the pathobiology of specific innate immune mechanisms in viral infection and asthma. In the renewal of our AADCRC program, we will continue to focus on the critical and often understudied innate immune factors surfactant protein-A (SP-A), the anion lipids of surfactant, (palmitoyl-oleoyl-phosphatidylglycerol (POPG) and phosphatidylinositol (PI)) and Toll interacting protein (Tollip), an innate immune mediator known to cross talk with SP-A and the anionic lipids. Each of these mediators works synergistically to modulate inflammatory and immunologic responses in asthma and infection given their complementary functions. Our exciting preliminary data underpin our program’s overall hypothesis that POPG/PI, Tollip and SP-A function as unique immune modulators that attenuate the impact of specific viral infections (RV-C, Influenza A and SARS-CoV-2) in type-2 asthma. The investigators in this program have a long history of collaboration at the. University of Arizona and National Jewish Health; Cedar Sinai Medical Center is now included in this renewal. The Administrative Core (Core A) of this Program will perform an important role to maintain productive and vibrant collaboration, ensure and track adherence to NIH and other relevant regulations and guidelines, and manage activities that will continue to strengthen the research community surrounding this Program. The Administrative Core has the following Specific Aims: (1) Manage the day-to-day administrative details and programmatic needs of the AADCRC program by providing fiscal management, administering subcontracts, assuring that regulatory requirements in are met, and monitoring of progress with program objectives; (2) Create an infrastructure to facilitate communication between the projects, cores and. investigators, and NIH Program Directors and to provide conflict resolution should it be necessary; (3) Assist with dissemination of research findings in a timely fashion to the scientific community, both locally and nationally, and provide information to the public, including study participants; 4) Implement the Infrastructure and Opportunity Fund for the AADCRC. Our proposal builds upon our active and productive collaborations of over 20 years and will significantly enhance our understanding of the innate molecular mechanisms underlying the interaction between type 2 inflammation in and viral exacerbations of asthma. The strong synergy among our projects will accelerate progress toward novel therapies by demonstrating that the innate immune components under study protect against viral infection in asthma.