Administrative Core

行政核心

基本信息

  • 批准号:
    10261953
  • 负责人:
  • 金额:
    $ 14.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-06-01 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

This U19 Asthma and Allergic Diseases Cooperative Research Center (AACDRC) Program brings together a team of investigators in three interactive projects and two cores to focus on the pathobiology of specific innate immune mechanisms in viral infection and asthma. In the renewal of our AADCRC program, we will continue to focus on the critical and often understudied innate immune factors surfactant protein-A (SP-A), the anion lipids of surfactant, (palmitoyl-oleoyl-phosphatidylglycerol (POPG) and phosphatidylinositol (PI)) and Toll interacting protein (Tollip), an innate immune mediator known to cross talk with SP-A and the anionic lipids. Each of these mediators works synergistically to modulate inflammatory and immunologic responses in asthma and infection given their complementary functions. Our exciting preliminary data underpin our program’s overall hypothesis that POPG/PI, Tollip and SP-A function as unique immune modulators that attenuate the impact of specific viral infections (RV-C, Influenza A and SARS-CoV-2) in type-2 asthma. The investigators in this program have a long history of collaboration at the. University of Arizona and National Jewish Health; Cedar Sinai Medical Center is now included in this renewal. The Administrative Core (Core A) of this Program will perform an important role to maintain productive and vibrant collaboration, ensure and track adherence to NIH and other relevant regulations and guidelines, and manage activities that will continue to strengthen the research community surrounding this Program. The Administrative Core has the following Specific Aims: (1) Manage the day-to-day administrative details and programmatic needs of the AADCRC program by providing fiscal management, administering subcontracts, assuring that regulatory requirements in are met, and monitoring of progress with program objectives; (2) Create an infrastructure to facilitate communication between the projects, cores and. investigators, and NIH Program Directors and to provide conflict resolution should it be necessary; (3) Assist with dissemination of research findings in a timely fashion to the scientific community, both locally and nationally, and provide information to the public, including study participants; 4) Implement the Infrastructure and Opportunity Fund for the AADCRC. Our proposal builds upon our active and productive collaborations of over 20 years and will significantly enhance our understanding of the innate molecular mechanisms underlying the interaction between type 2 inflammation in and viral exacerbations of asthma. The strong synergy among our projects will accelerate progress toward novel therapies by demonstrating that the innate immune components under study protect against viral infection in asthma.
这个U19哮喘和过敏性疾病合作研究中心(AACDRC)项目汇集了一个

项目成果

期刊论文数量(0)
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专利数量(0)

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Monica Kraft其他文献

Monica Kraft的其他文献

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{{ truncateString('Monica Kraft', 18)}}的其他基金

The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center
杜克大学正常组织衰老细胞评估 (SCENT) 绘图中心
  • 批准号:
    10689774
  • 财政年份:
    2021
  • 资助金额:
    $ 14.68万
  • 项目类别:
The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC)
COVID-19 队列中的免疫表型评估 (IMPACC)
  • 批准号:
    10204632
  • 财政年份:
    2020
  • 资助金额:
    $ 14.68万
  • 项目类别:
Clinical Core
临床核心
  • 批准号:
    10216759
  • 财政年份:
    2020
  • 资助金额:
    $ 14.68万
  • 项目类别:
University of Arizona-Banner Health All of Us Research Program
亚利桑那大学横幅健康研究计划
  • 批准号:
    10338519
  • 财政年份:
    2018
  • 资助金额:
    $ 14.68万
  • 项目类别:
Surfactant Protein-A and Type 2 Asthma in SARS-CoV-2 Infection
SARS-CoV-2 感染中的表面活性蛋白 A 和 2 型哮喘
  • 批准号:
    10661671
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Innate Immunity and Viral Infection in Asthma
哮喘的先天免疫和病毒感染
  • 批准号:
    10473849
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Surfactant Protein-A and Type 2 Asthma in SARS-CoV-2 Infection
SARS-CoV-2 感染中的表面活性蛋白 A 和 2 型哮喘
  • 批准号:
    10261957
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10473850
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Surfactant Protein-A and Type 2 Asthma in SARS-CoV-2 Infection
SARS-CoV-2 感染中的表面活性蛋白 A 和 2 型哮喘
  • 批准号:
    10473864
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Dysfunction of Innate Immunity in Asthma
哮喘的先天免疫功能障碍
  • 批准号:
    9156365
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:

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%20创新、%20AI驱动%20康复%20平台%20%20增加%20依从性、%20增强%20治疗后%20结果%20by%20at%20至少%2050%、%20和%20提供%20成本%20节省%20of%2095%
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