Administrative Core

行政核心

基本信息

  • 批准号:
    10261953
  • 负责人:
  • 金额:
    $ 14.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-06-01 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

This U19 Asthma and Allergic Diseases Cooperative Research Center (AACDRC) Program brings together a team of investigators in three interactive projects and two cores to focus on the pathobiology of specific innate immune mechanisms in viral infection and asthma. In the renewal of our AADCRC program, we will continue to focus on the critical and often understudied innate immune factors surfactant protein-A (SP-A), the anion lipids of surfactant, (palmitoyl-oleoyl-phosphatidylglycerol (POPG) and phosphatidylinositol (PI)) and Toll interacting protein (Tollip), an innate immune mediator known to cross talk with SP-A and the anionic lipids. Each of these mediators works synergistically to modulate inflammatory and immunologic responses in asthma and infection given their complementary functions. Our exciting preliminary data underpin our program’s overall hypothesis that POPG/PI, Tollip and SP-A function as unique immune modulators that attenuate the impact of specific viral infections (RV-C, Influenza A and SARS-CoV-2) in type-2 asthma. The investigators in this program have a long history of collaboration at the. University of Arizona and National Jewish Health; Cedar Sinai Medical Center is now included in this renewal. The Administrative Core (Core A) of this Program will perform an important role to maintain productive and vibrant collaboration, ensure and track adherence to NIH and other relevant regulations and guidelines, and manage activities that will continue to strengthen the research community surrounding this Program. The Administrative Core has the following Specific Aims: (1) Manage the day-to-day administrative details and programmatic needs of the AADCRC program by providing fiscal management, administering subcontracts, assuring that regulatory requirements in are met, and monitoring of progress with program objectives; (2) Create an infrastructure to facilitate communication between the projects, cores and. investigators, and NIH Program Directors and to provide conflict resolution should it be necessary; (3) Assist with dissemination of research findings in a timely fashion to the scientific community, both locally and nationally, and provide information to the public, including study participants; 4) Implement the Infrastructure and Opportunity Fund for the AADCRC. Our proposal builds upon our active and productive collaborations of over 20 years and will significantly enhance our understanding of the innate molecular mechanisms underlying the interaction between type 2 inflammation in and viral exacerbations of asthma. The strong synergy among our projects will accelerate progress toward novel therapies by demonstrating that the innate immune components under study protect against viral infection in asthma.
U19哮喘和过敏性疾病合作研究中心(AACDRC)项目汇集了 三个互动项目和两个核心的研究团队,专注于特定先天的病理生物学 病毒感染和哮喘的免疫机制。在更新我们的AADCRC计划时,我们将继续 为了关注关键的、通常被忽视的天然免疫因子表面活性蛋白-A(SP-A), 表面活性剂的阴离子脂(棕榈酰-油酰-磷脂酰甘油(POPG)和磷脂酰肌醇(PI)) 和Toll相互作用蛋白(Tollip),一种已知与SP-A和 阴离子脂类。这些介质中的每一个都协同作用来调节炎症和免疫。 鉴于哮喘和感染的互补功能,它们的反应。我们激动人心的初步数据支撑着 我们项目的总体假设是POPG/PI、Tollip和SP-A作为独特的免疫调节剂发挥作用 减弱2型中特定病毒感染(RV-C、甲型流感和SARS-CoV-2)的影响 哮喘。该项目的调查人员在该项目中有很长的合作历史。亚利桑那大学和 国家犹太人健康中心;锡达西奈医疗中心现在包括在这次更新中。行政核心 本计划的(核心A)将发挥重要作用,以保持富有成效和活力的协作,确保 并跟踪对NIH和其他相关法规和指南的遵守情况,并管理将 继续加强围绕该计划的研究社区。行政核心具有 以下具体目标:(1)管理日常行政细节和方案需求 AADCRC通过提供财务管理、管理分包合同、确保监管 满足中的要求,并根据计划目标监控进度;(2)创建基础设施以 促进项目、核心和项目之间的沟通。调查人员、NIH项目主任和TO 在必要时提供冲突解决;(3)及时协助传播研究成果 向地方和全国科学界宣传,并向公众提供信息,包括 研究参与者;4)为亚洲及太平洋发展研究中心实施基础设施和机会基金。我们的提案建立了 基于我们20多年来积极和富有成效的合作,并将显著增进我们的理解 2型炎症与病毒相互作用的内在分子机制 哮喘加重。我们项目之间的强大协同作用将加快创新的进展 通过证明研究中的先天免疫成分预防病毒而进行的治疗 哮喘中的感染。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Monica Kraft其他文献

Monica Kraft的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Monica Kraft', 18)}}的其他基金

The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center
杜克大学正常组织衰老细胞评估 (SCENT) 绘图中心
  • 批准号:
    10689774
  • 财政年份:
    2021
  • 资助金额:
    $ 14.68万
  • 项目类别:
The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC)
COVID-19 队列中的免疫表型评估 (IMPACC)
  • 批准号:
    10204632
  • 财政年份:
    2020
  • 资助金额:
    $ 14.68万
  • 项目类别:
Clinical Core
临床核心
  • 批准号:
    10216759
  • 财政年份:
    2020
  • 资助金额:
    $ 14.68万
  • 项目类别:
University of Arizona-Banner Health All of Us Research Program
亚利桑那大学横幅健康研究计划
  • 批准号:
    10338519
  • 财政年份:
    2018
  • 资助金额:
    $ 14.68万
  • 项目类别:
Surfactant Protein-A and Type 2 Asthma in SARS-CoV-2 Infection
SARS-CoV-2 感染中的表面活性蛋白 A 和 2 型哮喘
  • 批准号:
    10661671
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Innate Immunity and Viral Infection in Asthma
哮喘的先天免疫和病毒感染
  • 批准号:
    10473849
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Surfactant Protein-A and Type 2 Asthma in SARS-CoV-2 Infection
SARS-CoV-2 感染中的表面活性蛋白 A 和 2 型哮喘
  • 批准号:
    10261957
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10473850
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Surfactant Protein-A and Type 2 Asthma in SARS-CoV-2 Infection
SARS-CoV-2 感染中的表面活性蛋白 A 和 2 型哮喘
  • 批准号:
    10473864
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:
Dysfunction of Innate Immunity in Asthma
哮喘的先天免疫功能障碍
  • 批准号:
    9156365
  • 财政年份:
    2016
  • 资助金额:
    $ 14.68万
  • 项目类别:

相似海外基金

I-Corps: Medication Adherence System
I-Corps:药物依从性系统
  • 批准号:
    2325465
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
    Standard Grant
Improving Repositioning Adherence in Home Care: Supporting Pressure Injury Care and Prevention
提高家庭护理中的重新定位依从性:支持压力损伤护理和预防
  • 批准号:
    490105
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
    Operating Grants
An innovative, AI-driven prehabilitation platform that increases adherence, enhances post-treatment outcomes by at least 50%, and provides cost savings of 95%.
%20创新、%20AI驱动%20康复%20平台%20%20增加%20依从性、%20增强%20治疗后%20结果%20by%20at%20至少%2050%、%20和%20提供%20成本%20节省%20of%2095%
  • 批准号:
    10057526
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
    Grant for R&D
CO-LEADER: Intervention to Improve Patient-Provider Communication and Medication Adherence among Patients with Systemic Lupus Erythematosus
共同领导者:改善系统性红斑狼疮患者的医患沟通和药物依从性的干预措施
  • 批准号:
    10772887
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk
Nuestro Sueno:夫妻干预措施的文化适应,以改善拉丁裔夫妇的 PAP 依从性和睡眠健康,对阿尔茨海默病风险产生影响
  • 批准号:
    10766947
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
  • 批准号:
    10594350
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
Unintrusive Pediatric Logging Orthotic Adherence Device: UPLOAD
非侵入式儿科记录矫形器粘附装置:上传
  • 批准号:
    10821172
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
病毒抑制的艾滋病毒和中风患者的抗逆转录病毒治疗依从性和探索性蛋白质组学
  • 批准号:
    10748465
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
Improving medication adherence and disease control for patients with multimorbidity: the role of price transparency tools
提高多病患者的药物依从性和疾病控制:价格透明度工具的作用
  • 批准号:
    10591441
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
Development and implementation of peer-facilitated decision-making and referral support to increase uptake and adherence to HIV pre-exposure prophylaxis in African Caribbean and Black communities in Ontario
制定和实施同行协助决策和转介支持,以提高非洲加勒比地区和安大略省黑人社区对艾滋病毒暴露前预防的接受和依从性
  • 批准号:
    491109
  • 财政年份:
    2023
  • 资助金额:
    $ 14.68万
  • 项目类别:
    Fellowship Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了