Administrative Core

项目摘要 印第安纳大学血液学卓越合作中心(CCEH)的中心主题是 人和小鼠非恶性造血在造血干和细胞水平的调控 祖细胞(HPC)、细胞因子、趋化因子、生长因子和微环境。这是焦点所在 在上一次资助期内，该中心的总费用为300万美元。我们继续追求这一艰巨的目标，因为我们意识到 在这些领域，还有更多的问题需要严格定义。成员调查的目标 这个中心的作用是利用造血系统的不同成分来改进和推进 以HSC/HPC为基础的治疗的临床应用和疗效。治疗遗传性骨髓疾病-- 衍生细胞可以通过适用于许多疾病的细胞和遗传方法获得。 和精神障碍。然而，这些模式的成功应用需要更深入地理解 细胞、分子、生化HSC和HPC调节及造血参数对其影响 在移植中的有效利用，如归巢、细胞周期调节、自我更新、表观遗传学和状态 造血者的利基。拟议的儿童健康中心汇集了25名成员的积极参与，这些成员 是由美国国立卫生研究院、国防部或退伍军人事务部资助的。这些调查人员与不同的和 在造血学、造血干细胞生物学和其他学科方面的互补专业知识，直接或 间接作用于造血系统的多种成分。中华全国卫生研究院建议设立3个 生物医学研究核心专注于带来最先进的技术，推动 该中心的成员，全国其他类似的CCEH中心和全国范围内合格的调查人员 他们不属于任何NIDDK资助的CCEH。此外，IU-CCEH将有一个浓缩计划 核心任务是为对非恶性肿瘤感兴趣的年轻和未来科学家建立培训计划 血液学研究。Iu-CCEH的具体目标是：1)建立、运行和管理三个至关重要的 为IUSM的研究人员和IUSM以外的其他人提供基本服务的生物医学核心 参与HSC/HPC生物学领域最高质量的非恶性基础和临床研究。2)建立， 实施和管理一项充实计划，以支持、促进和加强青少年的研究 非恶性HSC调控和HSC临床应用领域的研究。3)积极参与 实施由所有NIDDK赞助的伙伴试点和可行性筹资机制 美国各地的CCEH中心协调拟议应用程序核心的财务管理。5) 与全国其他CCEH中心密切合作，制定和实施政策、资金 机制，以及通过我们建议的针对年轻和成熟调查人员的核心来实现以下目标 在最高级别推动和赞助不同领域的非恶性血液学研究。

Project Summary The central theme of the Indiana University (IU) Cooperative Center of Excellence in Hematology (CCEH) is the regulation of nonmalignant human and murine hematopoiesis at the level of hematopoietic stem (HSC) and progenitor (HPC) cells, cytokines, chemokines, growth factors, and the microenvironment. This was the focus of the IU-CCEH during the last funding period. We continue to pursue this hefty goal, as we realize that there is still much more that needs to be rigorously defined in these areas. The goals of the investigations of members of this center are to leverage different components of the hematopoietic system to improve and advance clinical utility and efficacy of HSC/HPC-based therapies. Treatment of inherited disorders of bone marrow- derived cells can be achieved by both cellular and genetic approaches that are applicable to many diseases and disorders. However, successful application of these modalities requires a deeper understanding of the cellular, molecular, biochemical HSC and HPC regulation and hematopoietic parameters impacting their efficient use in transplantation such as homing, cell cycle regulation, self-renewal, epigenetics, and the status of the hematopoietic niche. The proposed IU-CCEH brings together the active participation of 25 members who are well funded by the NIH, DoD, or the VA. These investigators are highly interactive with diverse and complementary expertise in hematopoiesis and HSC biology and other disciplines that impact directly or indirectly on multiple components of the hematopoietic system. The IU-CCEH proposes the establishment of 3 biomedical research cores focused on bringing state-of-the-art technologies that advance the work of the members of this center, other similar CCEH centers across the country, and qualified investigators nationwide who do not belong to any NIDDK-funded CCEH. In addition, the IU-CCEH will have an Enrichment Program Core tasked with establishing training programs for young and future scientists interested in nonmalignant hematology research. The specific aims of the IU-CCEH are: 1) Establish, operate, and administer three vital biomedical cores providing essential services to investigators at the IUSM and others outside the IUSM who are involved in the highest quality nonmalignant basic and clinical research in HSC/HPC biology. 2) Establish, operate and administer an Enrichment Program to support, promote and enhance the research of young investigators in the area of nonmalignant HSC regulation and clinical utility of HSC. 3) Actively participate in the implementation of a Partner Pilot and Feasibility funding mechanism organized by all NIDDK-sponsored CCEH centers across the U.S.A. 4) Coordinate fiscal management of the cores of the proposed application. 5) Work closely and cooperate with other CCEH centers nationwide to adopt and implement policies, funding mechanisms, and opportunities via our proposed cores targeting young as well as established investigators to promote and sponsor diverse areas of nonmalignant hematology research at the highest levels.