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中文摘要
翻译
动物模型模块 摘要 动物模型单元的目标是加强个人调查人员进行 视觉科学的前沿研究,包括研究视觉系统的正常功能和 疾病动物模型的产生和表征。我们的目标是:1)提供资源、支持 以及在超出个人能力的水平上进行动物研究所需的培训 实验室;2)通过共享资源,促进整个视觉科学家社区的共事, 技术和专业知识;以及3)让同事参与视觉研究,包括支持 下一代基础和临床科学家。为实现这些目标,本模块将支持 配备最先进的仪器设备的尖端设施,包括手术设备和 用于动物眼睛和视觉表现的形态、功能和行为分析的仪器。 该模块由经验丰富的人员监督和操作,具有进行广泛的 一系列动物研究和对相关监管条件的深入了解。这些共享资源 将为有经验的和新手用户打开新的研究可能性,并将作为一个平台 促进我们研究社区的广泛互动。
英文摘要
Animal Models Module Abstract The objective of the Animal Models Module is to enhance the capabilities of individual investigators to conduct cutting edge research in the vision sciences, which involves studying normal function of the visual system and generation and characterization of animal models of disease. Our Aims are: 1) to provide resources, support and training required for conducting animal studies at the level exceeding the capabilities of any individual laboratory; 2) to promote collegiality across the community of vision scientists through sharing resources, techniques and expertise; and 3) to engage colleagues into conducting vision research, including support of the next generation of basic and clinician scientists. To achieve these Aims, this Module will support sophisticated facilities equipped with state-of-the-art instrumentation, including surgical equipment and instrumentation for morphological, functional and behavioral analyses of animal eyes and visual performance. The Module is supervised and operated by highly experienced personnel, with expertise in conducting a broad array of animal studies and deep understanding of associated regulatory conditions. These shared resources will open new research possibilities for both experienced and novice users, and will serve as a platform for fostering interactions among a broad swath of our research community.
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Deciphering the role of osteopontin in the aging eye and age-related macular degeneration
  • 批准号:
    10679287
  • 项目类别:
  • 资助金额:
    $45.47万
  • 财政年份:
    2023
  • 负责人:
    Goldis Malek
  • 依托单位:
Nuclear receptor driven mechanisms in aging and AMD
  • 批准号:
    10672924
  • 项目类别:
  • 资助金额:
    $47.27万
  • 财政年份:
    2021
  • 负责人:
    Goldis Malek
  • 依托单位:
Nuclear receptor driven mechanisms in aging and AMD
  • 批准号:
    10448330
  • 项目类别:
  • 资助金额:
    $45.85万
  • 财政年份:
    2021
  • 负责人:
    Goldis Malek
  • 依托单位:
Regulation of inflammation and lipid homeostasis by the aryl hydrocarbon receptor in age-related macular degeneration
  • 批准号:
    9542513
  • 项目类别:
  • 资助金额:
    $44.43万
  • 财政年份:
    2018
  • 负责人:
    Goldis Malek
  • 依托单位:
海外基金