Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research Network

慢性胰腺炎（CP）是一种进行性疾病，通常导致外分泌和内分泌功能丧失， 使人虚弱的腹痛;尚不清楚为什么有些人会进展并出现并发症，包括 胰源性糖尿病（T3 cDM）和/或胰腺癌（PDAC）。在慢性病研究联盟中， 胰腺炎，糖尿病和胰腺癌（CPDPC），最初形成于2015年，研究人员提出 并启动了几项关于风险因素、环境影响和概念验证研究的有力研究 推动该领域的发展，特别是那些增加T3 cDM和PDAC风险的因素。在第二 在CPDPC周期内，本行政补充文件将允许持续招募和保留受试者 在CPDPC的两项高优先级纵向研究中，即PROCEED和INSPPIRE 2，以及 DETECT旨在更好地定义和表征T3 cDM。

Chronic pancreatitis (CP) is a progressive disease, often leading to loss of exocrine and endocrine function and debilitating abdominal pain; it is unknown why some individuals progress and develop complications, including pancreatogenic diabetes (T3cDM) and/or pancreas cancer (PDAC). In the Consortium for the study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC), initially formed in 2015, investigators have proposed and initiated several well-powered studies of risk factors, environmental influences, and proof-of-concept studies to move the field forward, particularly those factors that increase the risk of T3cDM and PDAC. In the second cycle of the CPDPC, this administrative supplement will allow for ongoing recruitment and retention of subjects in two of the CPDPC's high-priority longitudinal studies, namely PROCEED and INSPPIRE 2, as well as DETECT, designed to better define and characterize T3cDM.