Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research Network

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Chronic pancreatitis (CP) is a progressive disease, often leading to loss of exocrine and endocrine function and debilitating abdominal pain; it is unknown why some individuals progress and develop complications, including pancreatogenic diabetes (T3cDM) and/or pancreas cancer (PDAC). In the Consortium for the study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC), initially formed in 2015, investigators have proposed and initiated several well-powered studies of risk factors, environmental influences, and proof-of-concept studies to move the field forward, particularly those factors that increase the risk of T3cDM and PDAC. In the second cycle of the CPDPC, this administrative supplement will allow for ongoing recruitment and retention of subjects in two of the CPDPC's high-priority longitudinal studies, namely PROCEED and INSPPIRE 2, as well as DETECT, designed to better define and characterize T3cDM.