Pharmacokinetic/Pharmacodynamic model in pregnant women with depression to guide sertraline dosing

抑郁症孕妇的药代动力学/药效学模型指导舍曲林给药

基本信息

  • 批准号:
    10390578
  • 负责人:
  • 金额:
    $ 22.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-18 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Abstract Depression and anxiety during pregnancy affect over 10% of women with 6-8% of pregnant women receiving a prescription for a selective serotonin reuptake inhibitor (SSRI) antidepressant. Sertraline is the most commonly prescribed SSRI in women of reproductive years. However, there remains limited information for optimizing its treatment during pregnancy. Sertraline shows large inter-individual variability although studies generally suffer from small sample sizes and inconsistent observations. Physiological changes accompanying pregnancy can alter drug pharmacokinetics (e.g., clearance) which can significantly affect steady-state concentrations of medications, supporting the need for dose adjustments in order to maintain pre-pregnancy drug exposure. Our objective is to quantify the contribution of sertraline pharmacokinetic exposure to maternal health and obstetrical/neonatal outcomes. The Women’s Mental Health Program database contains prospectively collected data from more than 2,500 individuals with neuropsychiatric illnesses across more than 15,000 unique visits during the perinatal and postpartum periods. Sertraline and metabolite concentrations along with maternal symptoms and obstetrical/neonatal outcome information will be analyzed via pharmacokinetic/pharmacodynamic modeling enabling characterization of the relationships between changes in sertraline exposure with maternal symptoms of depression and neonatal outcomes during pregnancy and postpartum. Results from this project will support refinement of dosing strategies and evidence-based personalized treatment planning for the use of sertraline during pregnancy. The application of pharmacokinetic- guided dosing will result in enhanced prevention of disease-related symptoms and improved maternal and child health. This project will provide the foundation for investigation of other antidepressants and psychotropic medications used during pregnancy.
摘要

项目成果

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ANGELA K BIRNBAUM其他文献

ANGELA K BIRNBAUM的其他文献

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{{ truncateString('ANGELA K BIRNBAUM', 18)}}的其他基金

Pharmacokinetic/Pharmacodynamic model in pregnant women with depression to guide sertraline dosing
抑郁症孕妇的药代动力学/药效学模型指导舍曲林给药
  • 批准号:
    10685934
  • 财政年份:
    2022
  • 资助金额:
    $ 22.35万
  • 项目类别:
Physiological-based Pharmacokinetics Approach to Determine the Extent of Drug Exposure of Antiseizure Medications During Pregnancy and Breastfeeding
基于生理学的药代动力学方法确定妊娠和哺乳期间抗癫痫药物的药物暴露程度
  • 批准号:
    10461805
  • 财政年份:
    2021
  • 资助金额:
    $ 22.35万
  • 项目类别:
Clinical Impact of Unstable AED Levels in Elderly Nursing Home Epilepsy Patients
不稳定的 AED 水平对老年疗养院癫痫患者的临床影响
  • 批准号:
    7319735
  • 财政年份:
    2007
  • 资助金额:
    $ 22.35万
  • 项目类别:
Clinical Impact of Unstable AED Levels in Elderly Nursing Home Epilepsy Patients
不稳定的 AED 水平对老年疗养院癫痫患者的临床影响
  • 批准号:
    7676030
  • 财政年份:
    2007
  • 资助金额:
    $ 22.35万
  • 项目类别:
Clinical Impact of Unstable AED Levels in Elderly Nursing Home Epilepsy Patients
不稳定的 AED 水平对老年疗养院癫痫患者的临床影响
  • 批准号:
    8130874
  • 财政年份:
    2007
  • 资助金额:
    $ 22.35万
  • 项目类别:
Clinical Impact of Unstable AED Levels in Elderly Nursing Home Epilepsy Patients
不稳定的 AED 水平对老年疗养院癫痫患者的临床影响
  • 批准号:
    7917240
  • 财政年份:
    2007
  • 资助金额:
    $ 22.35万
  • 项目类别:
Clinical Impact of Unstable AED Levels in Elderly Nursing Home Epilepsy Patients
不稳定的 AED 水平对老年疗养院癫痫患者的临床影响
  • 批准号:
    7487847
  • 财政年份:
    2007
  • 资助金额:
    $ 22.35万
  • 项目类别:
PHARMACOEPIDEMIOLOGY OF THE ANTIEPILEPTIC DRUGS
抗癫痫药物的药物流行病学
  • 批准号:
    7119180
  • 财政年份:
    2005
  • 资助金额:
    $ 22.35万
  • 项目类别:
PHARMACOEPIDEMIOLOGY OF THE ANTIEPILEPTIC DRUGS
抗癫痫药物的药物流行病学
  • 批准号:
    6666466
  • 财政年份:
    2002
  • 资助金额:
    $ 22.35万
  • 项目类别:
PHARMACOEPIDEMIOLOGY OF THE ANTIEPILEPTIC DRUGS
抗癫痫药物的药物流行病学
  • 批准号:
    7281604
  • 财政年份:
  • 资助金额:
    $ 22.35万
  • 项目类别:

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