Functional peripheral and central vagal neural circuits of interoception inhibiting pain

内感受抑制疼痛的功能性外周和中枢迷走神经回路

基本信息

  • 批准号:
    10390781
  • 负责人:
  • 金额:
    $ 73.83万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-01 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

Functional peripheral and central vagal neural circuits of interoception inhibiting pain Interoception is the sense of the physiological condition of the body, and is critical for maintaining homeostasis and regulating cognitive and emotional processes. The neural processing of interoception can be regulated by electrical stimulation of the vagus nerve, which led to an FDA-approved therapy for seizure and depression. Interestingly, vagal stimulation also modulates intractable chronic pain in patients. However, the road to improving chronic pain management through the regulation of interoceptive inputs is blocked by our ignorance of the neurobiological mechanisms whereby vagal activity modulates chronic pain, posing a significant hurdle. To overcome this hurdle, we will focus on the neural mechanisms of vagal modulation in a mouse model of inflammation in temporomandibular joint (TMJ), a surrogate model of temporomandibular disorders (TMD). TMD is a prevalent form of chronic pain that often occurs as a comorbidity with other chronic pain conditions, such as migraine and fibromyalgia. Since chronic pain involves a wide range of neural processes ranging from peripheral nociception to affective and cognitive processing in the brain, it is possible that interoceptive inputs regulate pain pathways through multiple peripheral and central mechanisms. Vagal stimulation was suggested to inhibit transmission of pain signals at spinal cord through the regulation of descending pain modulatory pathways. Considering the high comorbidity of chronic pain and affective disorders, such as anxiety or depression, vagal inputs likely modulate pain through regulation of brain regions involved in emotional regulation. Furthermore, pain is driven by nociceptive processing by pain-sensing nerves at peripheral tissues, but vagal regulation of nociception in the periphery has not been reported. Here, our objective is to determine functional neural mechanisms by which interoception inhibits pain. Our central hypothesis is that vagal interoceptive circuits intersect with peripheral and central nociceptive pathways to inhibit pain from TMJ. We will test this hypothesis in the following specific aims.
功能外周和中枢迷走神经回路抑制感觉间疼痛

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Man-Kyo Chung其他文献

Man-Kyo Chung的其他文献

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{{ truncateString('Man-Kyo Chung', 18)}}的其他基金

Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling
三叉神经伤害感受器:慢性疼痛和牙槽骨重塑的神经交叉
  • 批准号:
    10660590
  • 财政年份:
    2022
  • 资助金额:
    $ 73.83万
  • 项目类别:
Functional peripheral and central vagal neural circuits of interoception inhibiting pain
内感受抑制疼痛的功能性外周和中枢迷走神经回路
  • 批准号:
    10615995
  • 财政年份:
    2022
  • 资助金额:
    $ 73.83万
  • 项目类别:
Functional peripheral and central vagal neural circuits of interoception inhibiting pain
内感受抑制疼痛的功能性外周和中枢迷走神经回路
  • 批准号:
    10544768
  • 财政年份:
    2022
  • 资助金额:
    $ 73.83万
  • 项目类别:
Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling
三叉神经伤害感受器:慢性疼痛和牙槽骨重塑的神经交叉
  • 批准号:
    10440485
  • 财政年份:
    2020
  • 资助金额:
    $ 73.83万
  • 项目类别:
Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling
三叉神经伤害感受器:慢性疼痛和牙槽骨重塑的神经交叉
  • 批准号:
    10645196
  • 财政年份:
    2020
  • 资助金额:
    $ 73.83万
  • 项目类别:
Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling
三叉神经伤害感受器:慢性疼痛和牙槽骨重塑的神经交叉
  • 批准号:
    10087568
  • 财政年份:
    2020
  • 资助金额:
    $ 73.83万
  • 项目类别:
Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling
三叉神经伤害感受器:慢性疼痛和牙槽骨重塑的神经交叉
  • 批准号:
    10256741
  • 财政年份:
    2020
  • 资助金额:
    $ 73.83万
  • 项目类别:
Primary afferent plasticity in chronic pain
慢性疼痛的初级传入可塑性
  • 批准号:
    10020475
  • 财政年份:
    2019
  • 资助金额:
    $ 73.83万
  • 项目类别:
Primary afferent plasticity in chronic pain
慢性疼痛的初级传入可塑性
  • 批准号:
    10187545
  • 财政年份:
    2018
  • 资助金额:
    $ 73.83万
  • 项目类别:
Primary afferent plasticity in chronic pain
慢性疼痛的初级传入可塑性
  • 批准号:
    9766271
  • 财政年份:
    2018
  • 资助金额:
    $ 73.83万
  • 项目类别:
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