ncRNA: Structure, Interactions and Inhibition

ncRNA:结构、相互作用和抑制

基本信息

  • 批准号:
    10391314
  • 负责人:
  • 金额:
    $ 63.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-04-01 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract This project studies the structural principles underlying the biological function of non- coding RNAs and investigates new approaches to inhibiting their function in disease. It studies how these transcripts fold; how they recognize other RNAs, RNA-binding proteins and epigenetic enzymes; how functional SNPs correlated with cancer progression or patient prognosis affect RNA structure and protein binding. It aims to develop engineered proteins and peptide mimetics to inhibit ncRNA misfunction in human cancers. Its premise is that providing molecular mechanistic insight on ncRNA through structure analysis and the establishment of structure-function relationships is one of the most important current outstanding questions in molecular structural biology, because of the enormous gap in knowledge created by the discovery that hundreds of thousands of transcripts are actively transcribed. Furthermore, the widespread occurrence of functional genetic variation in ncRNAs, and the association of mutation or mis-expression of ncRNAs with disease outcome in patients underscore the biomedical importance of these transcripts and reveal their potential therapeutic value. Molecular insight is necessary to fully understand their biological function, frame hypotheses on how misregulation, mutation or post-transcriptional modification causally lead to human disease, identify and validate molecular targets and discover new chemistry for pharmacological intervention. These broad goals will be pursued through a multi-scale approach to establishing the structure of ncRNAs, including the high resolution investigation of domains where specific functions reside, and of their interaction with proteins and microRNAs. The project will also pursue the further development of engineered proteins and peptide mimetics that target functional domains of ncRNAs involved in malignant transformation. In collaboration with cancer and developmental biologists, we will conduct experiments in primary cell lines and model organisms to parallel our biochemical, biophysical and structural investigations, and obtain cellular and organismal validation of the activity and mechanism of action of new inhibitors.
项目总结/文摘

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Gabriele Varani其他文献

Gabriele Varani的其他文献

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{{ truncateString('Gabriele Varani', 18)}}的其他基金

ncRNA: Structure, Interactions and Inhibition
ncRNA:结构、相互作用和抑制
  • 批准号:
    9899819
  • 财政年份:
    2018
  • 资助金额:
    $ 63.61万
  • 项目类别:
ncRNA: structure, function and inhibition
ncRNA:结构、功能和抑制
  • 批准号:
    10621500
  • 财政年份:
    2018
  • 资助金额:
    $ 63.61万
  • 项目类别:
ncRNA: Structure, Interactions and Inhibition
ncRNA:结构、相互作用和抑制
  • 批准号:
    9484123
  • 财政年份:
    2018
  • 资助金额:
    $ 63.61万
  • 项目类别:
Regulation of microRNA processing
microRNA 加工的调控
  • 批准号:
    8918684
  • 财政年份:
    2014
  • 资助金额:
    $ 63.61万
  • 项目类别:
Regulation of microRNA processing
microRNA 加工的调控
  • 批准号:
    9132816
  • 财政年份:
    2014
  • 资助金额:
    $ 63.61万
  • 项目类别:
Regulation of microRNA processing
microRNA 加工的调控
  • 批准号:
    8630834
  • 财政年份:
    2014
  • 资助金额:
    $ 63.61万
  • 项目类别:
UW Post-Baccalaureate Research Education Program (PREP)
华盛顿大学学士后研究教育计划 (PREP)
  • 批准号:
    8228011
  • 财政年份:
    2011
  • 资助金额:
    $ 63.61万
  • 项目类别:
UW Post-Baccalaureate Research Education Program (PREP)
华盛顿大学学士后研究教育计划 (PREP)
  • 批准号:
    8610322
  • 财政年份:
    2011
  • 资助金额:
    $ 63.61万
  • 项目类别:
UW Post-Baccalaureate Research Education Program (PREP)
华盛顿大学学士后研究教育计划 (PREP)
  • 批准号:
    10357912
  • 财政年份:
    2011
  • 资助金额:
    $ 63.61万
  • 项目类别:
UW Post-Baccalaureate Research Education Program (PREP)
华盛顿大学学士后研究教育计划 (PREP)
  • 批准号:
    9024553
  • 财政年份:
    2011
  • 资助金额:
    $ 63.61万
  • 项目类别:

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