Optimizing Brief Alcohol Interventions for Young Adults via Computational Methods

项目摘要 这个独立科学家奖（K 02）的目标是寻求一段密集的“保护时间”， 研究重点，以提高候选人的职业发展，并进行研究的比较 竞争性短暂酒精干预的有效性及其机制。拟议的研究战略 代表一个正在进行的，NIAAA支持的独立研究计划（R 01 AA 019511：估计 年轻人酒精干预的比较有效性，获得第3百分位数评分）。K02 通过以下方式扩展R 01：（1）包括额外的25组来自短暂饮酒的个体参与者数据 2013年至2020年期间进行的干预，以及（2）采用机器学习算法和其他 最先进的统计方法，以帮助确定行为变化的机制，并整合和 综合不同的研究。建议的受保护时间对于更新至关重要， 在当前快速变化的临床研究环境中丰富我的研究计划。随着积累 在新兴数据科学能力的背景下，存在高质量的临床数据和真实世界数据， 机遇与挑战并存。我非常适合应对前所未有的新挑战， 机会，鉴于我在统计数据整合和酒精研究的广泛经验的工作。我想 创建一个大型数据库，可以同时检查长期/队列效应，干预效应， 并通过开发和使用新工具在最细粒度的数据级别上影响异质性。我的职业目标是 成为“主要枢纽之一”，将不同的研究人员网络连接成一个大型的互联网络， 网络，促进流体相互作用。来自大型跨学科网络的协同作用将是有益的 创造大数据的“价值”主张--来自 调查人员之间的合作大于各自孤立的追求。为了实现这一目标，职业发展 活动将是（1）训练计算机器学习算法和真实世界的大维度数据 分析，以促进与成瘾研究人员和统计学家的合作;（2）提高我的理解 技术辅助的适应性干预措施和被动收集的结果数据;（3）更新我的 与成瘾相关的基础健康科学知识;（4）提交至少两份出版物和两份赠款 使用K 02项下提议的新获得的知识和技能。我已经确认了六个高度活跃的， 在各自领域享有盛誉的专家。我将有个人和小组的研究会议， 所有六个合作者（K 02的三个新合作者）开发创新项目。此外，我将 参加培训研讨会和会议，开展在线培训，并指导阅读， 与合作者讨论。我将拜访合作者进行深入讨论和解决问题。改善 生物医学和临床研究的大数据能力一直是NIH的主要战略计划之一， 我有动力并准备好帮助完成这一关键的使命。

Project Summary The goal of this Independent Scientist Award (K02) is to seek “protected time” for a period of intensive research focus to enhance the Candidate’s career development and to conduct research on the comparative effectiveness of competing brief alcohol interventions and their mechanisms. The proposed research strategy represents an ongoing, NIAAA-supported independent research program (R01 AA019511: Estimating Comparative Effectiveness of Alcohol Interventions for Young Adults, received 3rd percentile score). This K02 extends the R01 by (1) including an additional 25 data sets of individual participant data from brief alcohol interventions conducted between 2013 and 2020, and (2) embracing machine learning algorithms and other state-of-the-art statistical methods to help identify mechanisms of behavior change and to integrate and synthesize them across heterogeneous studies. The proposed protected time will be critical to update and enrich my research program in this current, rapidly changing clinical research environment. With accumulating high-quality clinical data and real-world data in the context of emerging data science capabilities, there exist opportunities as well as challenges. I am well suited to tackle emerging challenges for unprecedented opportunities, given my work in statistical data integration and broad experience in alcohol research. I want to create a large database where one can simultaneously examine secular/cohort effects, intervention effects, and effect heterogeneity at the most granular data level by developing and using new tools. My career goal is to become “one of the major hubs,” connecting disparate networks of researchers into a large connected network, promoting fluid interactions. The synergy from the large, interdisciplinary network would be helpful toward creating a “value” proposition of Big Data – the sum of the knowledge and insights from the collaboration by investigators is greater than isolated pursuits by each. Toward this goal, career development activities will be to (1) train in computational machine learning algorithms and real-world large-dimensional data analysis to facilitate collaboration with addiction researchers and statisticians; (2) enhance my understanding of technology-assisted adaptive interventions and passively collected outcomes data; (3) update my knowledge in basic health sciences related to addiction; and (4) submit at least two publications and two grants per year using newly acquired knowledge and skills proposed under K02. I have identified six highly active, nationally acclaimed experts in their respective fields. I will have individual and group research meetings with all six collaborators (three new collaborators for this K02) to develop innovative projects. In addition, I will attend workshops and conferences for training, carry out online training, and have guided reading and discussion with collaborators. I will visit collaborators for in-depth discussions and problem-solving. Improving big data capabilities for biomedical and clinical research has been one of the major strategic plans of the NIH, and I am motivated and prepared to help meet that critical mission.