Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy

项目摘要 长期持续的唾液分泌减少，也称为口干，在患者中很常见 头颈部癌症的放射治疗这种副作用会严重损害 影响患者的生活质量，难以补救。申请人最近的工作 发现唾液腺中丰富的巨噬细胞被 放疗，并且它们的恢复是恢复唾液分泌所必需的。这个的目标 建议是确定局部巨噬细胞在发育中的作用， 唾液腺的维持和再生，以及这些细胞对辐射的反应 修复因辐射而受损的唾液功能为了实现这些目标，该项目 将在上述条件下追踪局部巨噬细胞的起源， 去除这些细胞对唾液功能的影响，并查明哪些分子是 负责这些细胞的辐射损伤和唾液的恢复， 功能被辐射破坏。该项目的完成将揭示地方政府的重要作用。 巨噬细胞及其产物在维持唾液分泌，并形成基础 开发新的和可行的方法来治疗口干引起的 放疗

Project Summary The long lasting decrease of saliva secretion, also called dry mouth, is common in patients treated with radiotherapy for head and neck cancer. This side effect significantly impairs the quality of life of affected patients and is difficult to remedy. The applicant’s recent work revealed that macrophages abundant in salivary glands are sharply damaged by radiotherapy, and their recovery is required for restoring saliva secretion. The goals of this proposal are to determine the roles of local macrophages in the development, maintenance and regeneration of salivary glands, and how these cells respond to radiation and restore salivary function damaged by radiation. To achieve these goals, this project will trace the origin of local macrophages under conditions mentioned above, determine effects of removing these cells on salivary function, and pinpoint which molecules are responsible for the damage of these cells by radiation and for the recovery of salivary function damaged by radiation. Completion of this project will reveal vital roles of local macrophages and their products in the maintenance of saliva secretion, and form a basis for developing novel and feasible approaches to treating dry mouth caused by radiotherapy.