Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy
Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy
批准号:
10634722
负责人:
Fei Liu
金额:
$35.98万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-20 至 2026-06-30
关键词:
AddressAdultAffectAnti-Inflammatory AgentsBindingCellsCessation of lifeComplement 1qDendritesDevelopmentDuct (organ) structureEmbryoEndothelial CellsEpithelial CellsEpitheliumFeasibility StudiesFunctional RegenerationGene ExpressionGene TransferGoalsGrowth FactorHandHead and Neck CancerHomeostasisImmune responseImpairmentInflammationInflammatoryInfusion proceduresInterleukin-10Interleukin-15KineticsKnock-outKnowledgeLigationLymphoid CellMacrophageMaintenanceMembraneMolecularMorphologyMouse StrainsMusNatural regenerationOutcomeOutcomes ResearchOxidative StressPatientsPhagocytesPlayQuality of lifeRadiationRadiation induced damageRadiation therapyReactionReagentRecoveryRegenerative capacityResearchRoleSalivarySalivary GlandsSchemeSeveritiesSignal TransductionSourceTechnical ExpertiseTestingTransgenic MiceWorkXerostomiacell injurycell typecytokineepithelial stem cellgland developmenthead and neck cancer patientimprovedirradiationmonocytenovelnovel strategiesnovel therapeuticsparacrinepreservationprogenitorrestorationsaliva secretionself-renewalsensorside effectsuccesstherapeutic target
中文摘要
项目总结
英文摘要
Project Summary
The long lasting decrease of saliva secretion, also called dry mouth, is common in patients
treated with radiotherapy for head and neck cancer. This side effect significantly impairs
the quality of life of affected patients and is difficult to remedy. The applicant’s recent work
revealed that macrophages abundant in salivary glands are sharply damaged by
radiotherapy, and their recovery is required for restoring saliva secretion. The goals of this
proposal are to determine the roles of local macrophages in the development,
maintenance and regeneration of salivary glands, and how these cells respond to radiation
and restore salivary function damaged by radiation. To achieve these goals, this project
will trace the origin of local macrophages under conditions mentioned above, determine
effects of removing these cells on salivary function, and pinpoint which molecules are
responsible for the damage of these cells by radiation and for the recovery of salivary
function damaged by radiation. Completion of this project will reveal vital roles of local
macrophages and their products in the maintenance of saliva secretion, and form a basis
for developing novel and feasible approaches to treating dry mouth caused by
radiotherapy.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
DOI:
10.3390/antiox11102050
发表时间:
2022-10-18
期刊:
Antioxidants (Basel, Switzerland)
影响因子:
--
作者:
[]
通讯作者:
Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy
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批准号:10491123
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项目类别:
-
资助金额:$35.62万
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财政年份:2021
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负责人:Fei Liu
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依托单位:
Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy
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批准号:10390548
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项目类别:
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资助金额:$35.98万
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财政年份:2021
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负责人:Fei Liu
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依托单位:
The Mechanisms of Bone Mass Regulation by FIP200
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批准号:8531862
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项目类别:
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资助金额:$33.24万
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财政年份:2012
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负责人:Fei Liu
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依托单位:
Mechanisms of Hedgehog Mediated Rescue of Radiation-induced Hyposalivation
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批准号:8390974
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项目类别:
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资助金额:$36.55万
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财政年份:2012
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负责人:Fei Liu
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依托单位:
Mechanisms of Hedgehog Mediated Rescue of Radiation-induced Hyposalivation
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批准号:8685770
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项目类别:
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资助金额:$34.92万
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财政年份:2012
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负责人:Fei Liu
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依托单位:
Mechanisms of Hedgehog Mediated Rescue of Radiation-induced Hyposalivation
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批准号:8508916
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项目类别:
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资助金额:$34.99万
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财政年份:2012
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负责人:Fei Liu
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依托单位:
The Mechanisms of Bone Mass Regulation by FIP200
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批准号:9118872
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项目类别:
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资助金额:$34.99万
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财政年份:2012
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负责人:Fei Liu
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依托单位:
The mechanisms of bone mass regulation by FIP200
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批准号:8370347
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项目类别:
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资助金额:$34.99万
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财政年份:2012
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负责人:Fei Liu
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依托单位:
The Mechanisms of Bone Mass Regulation by FIP200
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批准号:8711015
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项目类别:
-
资助金额:$34.29万
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财政年份:2012
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负责人:Fei Liu
-
依托单位:
Mechanisms of Hedgehog Mediated Rescue of Radiation-induced Hyposalivation
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批准号:8878039
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项目类别:
-
资助金额:$34.95万
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财政年份:2012
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负责人:Fei Liu
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依托单位:
The Mechanisms of Bone Mass Regulation by FIP200
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批准号:8906745
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项目类别:
-
资助金额:$34.99万
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财政年份:2012
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负责人:Fei Liu
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依托单位:
The Mechanism of Excess Neural Crest-Derived Craniofacial Bone Formation in a Mou
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批准号:8235804
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项目类别:
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资助金额:$11.66万
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财政年份:2011
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负责人:Fei Liu
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依托单位:
The Mechanism of Excess Neural Crest-Derived Craniofacial Bone Formation in a Mou
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批准号:8091032
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项目类别:
-
资助金额:$11.64万
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财政年份:2011
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负责人:Fei Liu
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依托单位:
Modulating Wnt and Hedgehog Pathways for Functional Restoration of Salivary Gland
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批准号:7936136
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项目类别:
-
资助金额:$37.87万
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财政年份:2009
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负责人:Fei Liu
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依托单位:
Modulating Wnt and Hedgehog Pathways for Functional Restoration of Salivary Gland
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批准号:7818805
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项目类别:
-
资助金额:$38.4万
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财政年份:2009
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负责人:Fei Liu
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依托单位:
海外基金