Patterns of Cardiopulmonary health across the life course

整个生命过程中心肺健康的模式

基本信息

  • 批准号:
    10634635
  • 负责人:
  • 金额:
    $ 67.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-01 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT Chronic lung disease and heart failure (HF) are highly prevalent, commonly co-occur, and are associated with significant morbidity and mortality. Work from our group and others has demonstrated an independent relationship between chronic lung disease and incident HF that may be driven in part by inflammation. We have also documented that even in the absence of symptomatic lung disease, impaired lung function defined by spirometry is associated with adverse cardiac remodeling on echocardiography and incident HF events. While symptomatic lung disease and HF often occur in the elderly, many younger adults have relatively asymptomatic impairment in lung health and cardiac structure and function. These subclinical cardiopulmonary abnormalities develop during the key modifiable period from young adulthood to midlife. However, data are sparse on the timing and associated mechanisms of the transition from health to disease spanning young adulthood to midlife, and related race-sex differences. Without identifying these unique patterns of change, it will not be possible to screen for subclinical changes and employ prevention strategies prior to irreversible damage in the lung and heart. This requires upstream identification at the earliest detectable change. While spirometry is the gold standard for lung disease detection, it is a relatively crude and insensitive measure of impaired lung health. In contrast, lung injury (quantified using a novel local histogram analysis developed and validated by our group) from computed tomography (CT) scans is a more sensitive and earlier indicator of impaired lung health (e.g. due to tobacco, air pollution, and respiratory viral infection). Therefore, we now propose to take advantage of the Coronary Artery Risk Development in Young Adults (CARDIA) study’s unique platform to study the temporal relationship of and mechanisms underlying the transition from lung and heart health to disease. To-date, our group has investigated the predictors and consequences of impaired lung health and HF, separately, in CARDIA. In this project, we will build upon our prior work by analyzing CT scans to determine the concurrent evolution of lung injury and adverse cardiac remodeling and identify mechanisms by assaying a multitude of blood-based biomarkers (using a multiplexed array) and performing 4-dimensional flow cardiovascular magnetic resonance imaging (cMRI). We will test the hypothesis that detailed imaging and blood-based markers can inform clinically relevant endotypes reflecting dynamic changes in lung injury and adverse cardiac remodeling during a key vulnerable period of life through the following specific aims: (1) Determine the longitudinal association between lung injury and left ventricular end-diastolic volume (LVEDV); (2) Determine the risk of subclinical and clinical HF among joint lung injury and LVEDV trajectory groups; and (3) Determine the hemodynamic mediators of the association between lung injury and adverse cardiac remodeling. This study will investigate factors associated with transitions from cardiopulmonary health to disease and associated mechanisms, and in doing so, will identify screening strategies and contribute novel pathways for targeted disease interception of lung and heart disease.
摘要

项目成果

期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The 2017 American College of Cardiology/American Heart Association Hypertension Guideline and Blood Pressure in Older Adults.
2017 年美国心脏病学会/美国心脏协会高血压指南和老年人血压。
  • DOI:
    10.1016/j.amepre.2023.04.011
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    5.5
  • 作者:
    Wang,MichaelC;Petito,LuciaC;Pool,LindsayR;Foti,Kathryn;Juraschek,StephenP;McEvoy,JohnW;Nambi,Vijay;Carnethon,MercedesR;Michos,ErinD;Khan,SadiyaS
  • 通讯作者:
    Khan,SadiyaS
Moving the Paradigm Forward for Prediction and Risk-Based Primary Prevention of Heart Failure in Special Populations.
推动特殊人群心力衰竭预测和基于风险的一级预防的范例。
  • DOI:
    10.1007/s11883-022-01009-7
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    5.8
  • 作者:
    Everitt,IanK;Trinh,KatherineV;Underberg,DanielL;Beach,Lauren;Khan,SadiyaS
  • 通讯作者:
    Khan,SadiyaS
New strategies and therapies for the prevention of heart failure in high-risk patients.
  • DOI:
    10.1002/clc.23839
  • 发表时间:
    2022-06
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
  • 通讯作者:
Rural-Urban Trends for Aortic Stenosis Mortality in the United States, 2008-2019.
2008-2019 年美国主动脉瓣狭窄死亡率的城乡趋势。
  • DOI:
    10.1016/j.jacadv.2023.100617
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hughes,ZacharyH;Hammond,MichaelM;Lewis-Thames,Marquita;Sweis,Ranya;Shah,NilayS;Khan,SadiyaS
  • 通讯作者:
    Khan,SadiyaS
Hypertension-Related Cardiovascular Mortality in Asian American Subgroups.
亚裔美国人亚群体中与高血压相关的心血管死亡率。
  • DOI:
    10.1016/j.amepre.2023.01.003
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    5.5
  • 作者:
    Shah,NilayS;Shimbo,Daichi;Muntner,Paul;Huffman,MarkD;Kandula,NamrathaR;Mefford,MatthewT;Lloyd-Jones,DonaldM;Khan,SadiyaS
  • 通讯作者:
    Khan,SadiyaS
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Sadiya Sana Khan其他文献

DEVELOPMENT AND VALIDATION OF LONG-TERM RISK MODELS FOR PREDICTION OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE (ASCVD): THE CARDIOVASCULAR LIFETIME RISK POOLING PROJECT (LRPP)
  • DOI:
    10.1016/s0735-1097(24)03662-3
  • 发表时间:
    2024-04-02
  • 期刊:
  • 影响因子:
  • 作者:
    James W. Guo;Hongyan Ning;Sadiya Sana Khan;John Wilkins;Donald M. Lloyd-Jones
  • 通讯作者:
    Donald M. Lloyd-Jones
NURSE PRACTITIONER-LED, TEAM-BASED CARDIOVASCULAR-KIDNEY-METABOLIC CLINIC IMPROVES OUTCOMES: INITIAL EXPERIENCE IN AN AMBULATORY PRACTICE
以护士从业者为主导、基于团队的心血管-肾脏-代谢门诊改善结局:门诊实践中的初步经验
  • DOI:
    10.1016/s0735-1097(25)02996-1
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    22.300
  • 作者:
    Julie Vanourek;Jaime Hosler;Bridget Dolan Teschke;Aryelle Schicht;Kaleigh Powers;Andrew Kimmel;Brie Jeffries;Kim Mallon;John Mulrooney;Sarah M. Plaskett;Sadiya Sana Khan;Jane E. Wilcox;Matthew J. Feinstein;Mohamed Al-Kazaz;John Wilkins;Richard L. Weinberg;Neil J. Stone;Anthony Pick;Raja Kannan Mutharasan
  • 通讯作者:
    Raja Kannan Mutharasan
THE AMERICAN HEART ASSOCATION PREDICTING CARDIOVASCULAR DISEASE EVENT (PREVENT) EQUATIONS IN CHRONIC KIDNEY DISEASE
美国心脏协会慢性肾脏病心血管疾病事件预测方程(PREVENT)
  • DOI:
    10.1016/s0735-1097(25)00887-3
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    22.300
  • 作者:
    Nikitha Murthy;Alyssa Sanchez;Kevin Bryan Lo;Abiodun Benjamin Idowu;Katherine R. Tuttle;Janani Rangaswami;Sadiya Sana Khan;Roy Mathew
  • 通讯作者:
    Roy Mathew
CONTRIBUTIONS OF SOCIAL DETERMINANTS OF HEALTH TO RACIAL AND ETHNIC DIFFERENCES IN AGE OF ONSET OF HEART FAILURE
健康的社会决定因素对心力衰竭发病年龄方面种族和族裔差异的影响
  • DOI:
    10.1016/s0735-1097(25)05179-4
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    22.300
  • 作者:
    Xiaoning Huang;Lucia Petito;Gregg C. Fonarow;Faraz S. Ahmad;Nilay S. Shah;Sarah Chuzi;Kiarri Kershaw;Philip Greenland;Sadiya Sana Khan
  • 通讯作者:
    Sadiya Sana Khan
INCREMENTAL UTILITY OF LIPOPROTEIN(A) AND C-REACTIVE PROTEIN ON PREDICTION OF TOTAL CARDIOVASCULAR DISEASE USING THE PREVENT EQUATIONS: THE CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY
脂蛋白(A)和 C 反应蛋白对使用预防方程预测心血管疾病总体的增量效用:年轻成年人冠状动脉风险发展(CARDIA)研究
  • DOI:
    10.1016/s0735-1097(25)00882-4
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    22.300
  • 作者:
    John Ostrominski;Jane Y. Liu;Erin R. Wong;Andrew P. Ambrosy;Deepak K. Gupta;Sadiya Sana Khan;Alexander Blood;Nilay S. Shah;Donald M. Lloyd-Jones;Ankeet Bhatt
  • 通讯作者:
    Ankeet Bhatt

Sadiya Sana Khan的其他文献

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{{ truncateString('Sadiya Sana Khan', 18)}}的其他基金

Risk-Based Primary Prevention of Heart Failure
基于风险的心力衰竭一级预防
  • 批准号:
    10516468
  • 财政年份:
    2022
  • 资助金额:
    $ 67.79万
  • 项目类别:
Risk-Based Primary Prevention of Heart Failure
基于风险的心力衰竭一级预防
  • 批准号:
    10689211
  • 财政年份:
    2022
  • 资助金额:
    $ 67.79万
  • 项目类别:
CHIcago Center for Accelerating nextGen Omics, deep phenotyping, and data science in Heart Failure (CHICAGO-HF)
芝加哥加速心力衰竭下一代组学、深度表型分析和数据科学中心 (CHICAGO-HF)
  • 批准号:
    10483161
  • 财政年份:
    2021
  • 资助金额:
    $ 67.79万
  • 项目类别:
CHIcago Center for Accelerating nextGen Omics, deep phenotyping, and data science in Heart Failure (CHICAGO-HF)
芝加哥加速心力衰竭下一代组学、深度表型分析和数据科学中心 (CHICAGO-HF)
  • 批准号:
    10327554
  • 财政年份:
    2021
  • 资助金额:
    $ 67.79万
  • 项目类别:
PRegnancy OuTcomEs and subclinical Cardiovascular disease sTudy: (PROTECT)
妊娠结局和亚临床心血管疾病研究:(保护)
  • 批准号:
    10534752
  • 财政年份:
    2021
  • 资助金额:
    $ 67.79万
  • 项目类别:
PRegnancy OuTcomEs and subclinical Cardiovascular disease sTudy: (PROTECT)
妊娠结局和亚临床心血管疾病研究:(保护)
  • 批准号:
    10345228
  • 财政年份:
    2021
  • 资助金额:
    $ 67.79万
  • 项目类别:
CHIcago Center for Accelerating nextGen Omics, deep phenotyping, and data science in Heart Failure (CHICAGO-HF)
芝加哥加速心力衰竭下一代组学、深度表型分析和数据科学中心 (CHICAGO-HF)
  • 批准号:
    10679082
  • 财政年份:
    2021
  • 资助金额:
    $ 67.79万
  • 项目类别:
Patterns of Cardiopulmonary health across the life course
整个生命过程中心肺健康的模式
  • 批准号:
    10459504
  • 财政年份:
    2021
  • 资助金额:
    $ 67.79万
  • 项目类别:
Patterns of Cardiopulmonary health across the life course
整个生命过程中心肺健康的模式
  • 批准号:
    10280550
  • 财政年份:
    2021
  • 资助金额:
    $ 67.79万
  • 项目类别:
The Role of Plasminogen Activator Inhibitor-1 in the Development and Progression of Obesity
纤溶酶原激活剂抑制剂-1 在肥胖发生和进展中的作用
  • 批准号:
    8984104
  • 财政年份:
    2015
  • 资助金额:
    $ 67.79万
  • 项目类别:

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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