Mechanism of pulmonary endothelial cell heterogeneity and its role in disease

肺内皮细胞异质性机制及其在疾病中的作用

• 批准号: 10414872
• 负责人: Lisandra Vila Ellis
• 金额: $ 10.45万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10414872
• 关键词: ATAC-seq; Address; Adult; Affect; Alveolar; Alveolus; Appearance; Biology; Blood Vessels; Blood capillaries; Breeding; Bronchopulmonary Dysplasia; Cancer Center; Capillary Endothelial Cell; Cell Maturation; Cells; Congenital alveolar dysplasia; DNA; Data; Defect; Development; Developmental Biology; Disease; Embryo; Endothelial Cells; Endothelium; Ensure; Epithelial; Epithelial Cells; FOXF1 gene; Failure; Family; Foxes; Future; Gases; Genes; Genetic; Genetic Models; Genetic Transcription; Genomics; Heterogeneity; Human; Hyperoxia; Individual; Interruption; Link; Location; Lung; Lung diseases; Mentors; Mesenchymal; Modeling; Morphology; Mus; Myofibroblast; Names; Neonatal Hyperoxic Injury; Paper; Phase; Phenotype; Physicians; Physiological; Play; Population; Postdoctoral Fellow; Predisposition; Premature Infant; Process; Publishing; Pulmonary alveolar structure; Research; Retina; Role; SOX17 gene; Sampling; Scientist; Signal Transduction; Specific qualifier value; Surface; TP53 gene; Testing; Three-Dimensional Imaging; Time; Tissues; Training; VEGFA gene; Vascular System; Virus Diseases; Work; career; career development; cell fate specification; developmental disease; experience; lung development; mouse genetics; mouse model; mutant; novel; postnatal; protein expression; response; single-cell RNA sequencing; transcription factor; vascular abnormality

PROJECT SUMMARY/ABSTRACT Candidate: Dr. Lisandra Via Ellis is a physician with extensive training in vascular biology and lung development. She is a postdoctoral fellow at MD Anderson Cancer Center seeking to understand how blood vessels develop in the lung and how this process is affected in disease. She just published her first, first-author paper in Developmental Cell. Career development: Dr. Vila Ellis' mentors include Dr. Jichao Chen, a successful scientist who studies developmental biology in the mouse lung, and Dr. Burton Dickey, a physician who has over 30 years of research experience in the lung. Additionally, Dr. Vila Ellis will have the support of many collaborators in the field, as well as a mentoring committee to ensure she meets the expected milestones of this proposal, and guarantee a smooth transition to an independent career. Research: Dr. Vila Ellis' work has shown that Vascular endothelial growth factor A (Vegfa) specifies a novel population of endothelial cells in the lung. These cells are transcriptionally and morphologically distinct, and in their absence the alveolar space is aberrantly enlarged, reminiscent of bronchopulmonary dysplasia. In the future, Dr. Vila Ellis will study how this specification process happens and what role these new cells play in lung disease. In summary, this proposal will address the mechanisms of pulmonary endothelial cell heterogeneity and help establish the lung endothelium as a key component in the origin of developmental diseases.

项目总结/摘要 候选人：Lisandra Via Ellis博士是一名在血管生物学和肺发育方面接受过广泛培训的医生。 她是MD安德森癌症中心的博士后研究员，致力于了解血管是如何发育的 以及这个过程在疾病中是如何受到影响的。她刚刚发表了她的第一篇第一作者论文， 发育细胞。 职业发展：Vila Ellis博士的导师包括Jichao Chen博士，他是一位成功的科学家， 和伯顿·迪基博士，一位有着30多年研究经验的医生， 肺的经验。此外，Vila Ellis博士还将得到该领域许多合作者的支持 作为指导委员会，确保她达到本提案的预期里程碑，并保证 顺利过渡到独立职业。 研究：Vila Ellis博士的工作表明，血管内皮生长因子A（Vegfa）指定了一种新的 肺中的内皮细胞群。这些细胞在转录和形态上是不同的， 由于它们的缺失，肺泡腔异常扩大，让人想起支气管肺发育不良。在 未来，Vila Ellis博士将研究这种特化过程如何发生以及这些新细胞在肺中发挥什么作用。 疾病 总之，这项建议将解决肺内皮细胞异质性的机制，并有助于 建立肺内皮作为发育性疾病起源的关键组成部分。