Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/Malignancies

爱因斯坦/卢旺达/刚果民主共和国艾滋病毒/HPV/恶性肿瘤研究联盟

基本信息

批准号：
10414088
负责人：
Adebola Adedimeji
金额：
$ 96.32万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-21 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10414088
关键词：
AIDS prevention AIDS related cancer Accounting Acquired Immunodeficiency Syndrome Africa Africa South of the Sahara African Aging Anus Bacteria Cancer Etiology Caring Cervical Cervical Cancer Screening Cessation of life Clinical Clinical Research Collaborations Colorectal Congo Country Data Decision Making Democratic Republic of the Congo Development Diagnostics Research Disease Disease Progression Doctor of Philosophy Effectiveness Epidemic Epidemiology Financial Support Fostering Freezing Funding Growth HIV HIV Infections Head and Neck Cancer Health Histopathology Human Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Human papilloma virus infection Human papillomavirus 6 Immune response Incidence Infection Inflammatory Infrastructure Institution Kaposi Sarcoma Knowledge Laboratories Leadership Lesion Malignant Neoplasms Malignant neoplasm of anus Malignant neoplasm of cervix uteri Medicine Mentors Methods Military Hospitals Mission Molecular Diagnostic Testing Morbidity - disease rate Mucous Membrane Natural History Non-Hodgkin&apos s Lymphoma Operations Research Outcome Pathology Persons Physicians Pilot Projects Population Prevalence Principal Investigator Research Research Methodology Research Personnel Research Project Grants Research Training Resources Rwanda Scientist Specimen Handling Teaching Hospitals Training Translational Research United States Universities University Hospitals Vertical Disease Transmission Viral Viral Load result Woman antiretroviral therapy burden of illness cancer epidemiology career career development cervicovaginal cervicovaginal microbiome college disorder prevention dysbiosis effectiveness evaluation evidence base experience flexibility follow-up gut microbiome improved infrastructure development men men who have sex with men microbiota molecular diagnostics mortality next generation sequencing operation penile microbiota penis population based programs success sustainable resource vaccine effectiveness virus related cancer young woman

项目摘要

As millions of Africans living with HIV (LWH) live longer due to effective antiretroviral therapy (ART), their incidence of diseases of aging, including cancer, is increasing. Human papillomavirus (HPV) is the causal agent for almost all cervical and anal cancers, and ~50% of head and neck cancers. Cervical cancer, an AlDS- defining malignancy, is a leading cause of cancer deaths in women worldwide. The transforming capability of HPV is enhanced in women LWH (WLWH), whose HPV-related cervical lesions are more prevalent, more likely to progress, and more likely to become cancer. HPV also causes transformation of the anal mucosa. Men who have sex with men (MSM) constitute a substantial proportion of persons living with HIV (PLWH) around the world, and the incidence of HPV-related anal cancer is growing among MSM living with HIV. The incidence of cervical and anal cancers has not declined with the introduction of ART and remains elevated several fold in women and men LWH. We propose to establish an HIV-Associated HPV-related Malignancies Research Center (HAMRC) in Rwanda and the Democratic Republic of Congo (DRC), a partnership of four institutions: Albert Einstein College of Medicine, the University of Rwanda (UR), Rwanda Military Hospital (major teaching hospital for UR), and Université Protestante au Congo (UPC), to investigate HIV/HPV related cancers in Africa. This is an extension of our current U54-funded Rwanda/Einstein Research Consortium for HIV/HPV Malignancies, which has been highly successful in performing high-value rigorous research and developing laboratory and investigator research capacity. We will build upon and strengthen our existing partnerships to create a dynamic, integrated and flexible platform with academic, clinical and administrative expertise to support and foster the growth of scientific knowledge in HPV-related cancers in PLWH. We propose two research projects to be conducted over five years that can quickly impact the prevention of HIV/HPV cancers by supporting evidence-based decision-making to improve health outcomes: 1.) population based effectiveness of HPV vaccination in Rwandan women; and 2.) HPV prevalence and disease burden in men who have sex with men (MSM) in DRC and Rwanda. Embedded in both of these projects will be studies of the interaction of the local microbial flora with cervicovaginal, anal, and penile HPV infection. We propose to support both projects by developing laboratory capacity in molecular diagnostics in DRC, and in next generation sequencing (NGS) in Rwanda. Leadership will be provided by a team of four multiple principal investigators (MPIs): Kathryn Anastos MD, Leon Mutesa MD PhD, Marcel Yotebieng MD PhD, and Philip Castle PhD MPH, bringing strong experience in each or our three countries, Rwanda, DRC and the United States. Our Center, a collaboration of US, Rwandan and DRC institutions will serve as a national and regional resource hub in research, training, and career development for African scientific leaders in HIV/HPV-related cancers.

由于有效的抗逆转录病毒疗法（ART），数以百万计的非洲人（LWH）寿命更长，他们的衰老疾病（包括癌症）正在增加。人乳头瘤病毒（HPV）是因果关系几乎所有宫颈癌和肛门癌的代理，以及〜50％的头颈癌。宫颈癌，一个Alds- 定义恶性肿瘤是全球女性癌症死亡的主要原因。转换能力女性LWH（WLWH）增强了HPV，其HPV相关的宫颈病变更为普遍，更多可能进步，更有可能成为癌症。 HPV还引起肛门粘膜的转化。男人与男人发生性关系（MSM）占艾滋病毒（PLWH）的人中很大一部分在艾滋病毒的MSM中，世界以及与HPV相关的肛门癌的事件正在增长。事件宫颈癌和肛门癌的引入尚未下降，并且在男性和男人LWH。我们建议建立与HIV相关的HPV相关的恶性肿瘤研究中心（HAMRC）卢旺达和刚果民主共和国（DRC），四个机构的合作伙伴关系：阿尔伯特·爱因斯坦卢旺达军事医院（卢旺达大学）（UR）医学院（UR） UR）和新教大学Au Congo（UPC），以调查非洲的HIV/HPV相关癌症。这是我们目前由U54资助的卢旺达/爱因斯坦研究联盟的HIV/HPV MALIGNANCYS的扩展这在进行高价值严格的研究和发展实验室以及研究者研究能力。我们将基于并加强我们现有的伙伴关系，以创建一个具有学术，临床和行政专业知识的动态，集成和灵活的平台，以支持和在PLWH中促进HPV相关癌症中科学知识的增长。我们建议在五年内开展两个研究项目，以迅速影响通过支持基于证据的决策以改善健康结果来预防艾滋病毒/HPV癌症： 1.）HPV疫苗接种在卢旺达妇女中的有效性；和2.）HPV患病率和与男性发生性关系（MSM）的男性疾病燃烧。嵌入在这两个中项目将是对局部微生物菌群与宫颈阴道，肛门和阴茎HPV的相互作用的研究感染。我们建议通过在分子诊断中开发实验室能力来支持这两个项目 DRC，以及卢旺达的下一代测序（NGS）。领导将由四人组成多个主要研究人员（MPI）：Kathryn Anastos MD，Leon Mutesa MD博士，Marcel Yotebieng MD 博士学位和菲利普城堡博士MPH，在卢旺达州卢旺达州的每个或我们的三个国家都有丰富的经验和美国。我们的中心，我们的合作，卢旺达和刚果民主共和国机构将作为一个非洲科学领导者的研究，培训和职业发展方面的国家和地区资源枢纽在HIV/HPV相关的癌症中。