Research Program: Breast & Ovary Cancers

研究项目：乳房

• 批准号: 10636835
• 负责人: Cyrus M Ghajar
• 金额: $ 7.62万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10636835
• 关键词: BRCA1 gene; BRCA2 gene; Breast; Breast Cancer Prevention; Breast Cancer survivor; Breast Cancer therapy; Cancer Center Support Grant; Catchment Area; Center Core Grants; Cessation of life; Clinical; Communities; DNA; DNA Repair; Dedications; Defect; Derivation procedure; Detection; Diagnosis; Direct Costs; Disease; ERBB2 gene; Early Diagnosis; Exercise; Faculty; Fostering; Funding; Genetic Predisposition to Disease; Genetic Risk; Grant; Histologic; Hormonal; Incidence; Institution; Interdisciplinary Study; Intervention; Ionizing radiation; Localized Malignant Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Mammalian Oviducts; Mismatch Repair; Molecular; Mutation; Oncogenes; Ovary; PIK3CA gene; Paper; Peer Review; Peritoneum; Platinum Compounds; Poly(ADP-ribose) Polymerase Inhibitor; Population; Predisposition; Publishing; Reproductive Behavior; Research; Research Personnel; Research Project Grants; Research Support; Resistance; Resource Sharing; Resources; Risk; Risk Assessment; Secondary to; Serous; Survivors; Therapeutic; Tissues; Universities; Washington; Woman; Work; cancer care; cancer prevention; cancer type; cognitive rehabilitation; high risk; homologous recombination; hormone receptor-negative; improved; malignant breast neoplasm; meetings; member; molecular subtypes; mortality; overexpression; programs; rare cancer; recruit; response; stress reduction; survivorship; targeted treatment; therapeutic target; triple-negative invasive breast carcinoma

PROJECT SUMMARY: BREAST & OVARY CANCERS (BOC) The Breast & Ovary Cancers (BOC) Program brings together a highly cross-disciplinary and collaborative group of investigators dedicated to reducing the incidence and mortality of breast and ovary cancers. The program fosters interdisciplinary research at Fred Hutch (FH), University of Washington (UW), Seattle Cancer Care Alliance (SCCA), and in the community to improve cancer prevention, detection, diagnosis, and treatment. The BOC Program is led by Drs. Nancy Davidson and Elizabeth Swisher, along with Associate Program Leaders, Drs. Julie Gralow and Barbara Goff, who are leaders at the institutions described above. The Program aims to (1) improve strategies to assess risk, identify, screen, and prevent breast and ovary cancer in women, especially those at high risk and (2) develop targeted therapies for breast and ovary cancers with a special focus on improving response and predicting resistance. The BOC Program currently has 54 members with 11 based at Fred Hutch and 43 based at University of Washington. The current research support of BOC members is $14.7M (direct costs), of which $8.8M is peer- reviewed funding, including $3.5M from the NCI. BOC Program members published a total of 628 papers over the current grant period, of which 20% were intra-programmatic, 28% were inter-programmatic, and 47% had external co-authors. All 12 Consortium Shared Resources were utilized by BOC members in the course of their work. This P30 grant also assists this program by providing administrative and logistical support for BOC meetings, pilot funding for new research projects, and recruitment resources for new faculty.

项目概要：乳腺癌和卵巢癌（BOC） 乳腺癌和卵巢癌（BOC）计划汇集了一个高度跨学科和协作 致力于降低乳腺癌和卵巢癌发病率和死亡率的研究小组。的 一个计划促进弗雷德哈奇（FH），华盛顿大学（UW），西雅图癌症的跨学科研究 护理联盟（SCCA），并在社区改善癌症预防，检测，诊断， 治疗BOC项目由Nancy Davidson博士和Elizabeth Swisher博士领导，沿着 项目负责人Julie Gralow博士和Barbara Goff博士，他们是上述机构的领导人。 该计划旨在（1）改进评估风险、识别、筛查和预防乳腺癌和卵巢癌的战略 女性癌症，特别是高危女性;（2）开发乳腺癌和卵巢癌的靶向治疗 特别关注提高反应和预测抗性。 BOC计划目前有54名成员，其中11名来自Fred Hutch，43名来自University of 华盛顿。中国银行成员目前的研究支持为1470万美元（直接成本），其中880万美元是同行研究。 审查了资金，包括来自NCI的350万美元。BOC计划成员共发表论文628篇， 目前的赠款周期，其中20%是计划内的，28%是计划间的，47%是计划外的。 外部共同作者。所有12个联合体共享资源都由BOC成员在其 工作这笔P30赠款还通过为中国银行提供行政和后勤支持来协助该计划 会议，为新的研究项目提供试点资金，并为新的教师招聘资源。