ENhancing exercise with LIGHT to improve functioning in PAD: the ENLIGHTEN PAD Trial

利用 LIGHT 加强锻炼以改善 PAD 功能:ENLIGHTEN PAD 试验

基本信息

项目摘要

ENhancing exercise with LIGHT to improve functioning in PAD: the ENLIGHTEN PAD Trial Walking exercise is first line therapy for people disabled by lower extremity peripheral artery disease (PAD). However, walking exercise does not eliminate disability due to PAD. Even after completing one of our successful exercise interventions that meaningfully improved six-minute walk distance, 82% of 192 PAD participants still reported ischemic leg symptoms after the six-minute walk. Our LITE randomized trial of 305 people with PAD showed that, compared to a control group that did not exercise, home-based walking exercise that induced ischemic leg symptoms (i.e. high intensity) significantly improved six-minute walk, while home- based exercise that did not induce ischemic leg symptoms (i.e. low intensity) had no effect on six-minute walk. Despite greater benefits, ischemic leg symptoms during high intensity exercise reduced exercise adherence. We hypothesize that 670 nm light therapy, administered before home-based walking exercise, will increase minutes of high intensity exercise and enhance the benefits of exercise in PAD. Nitric oxide (NO) is an endogenous signaling molecule with therapeutic properties that improve limb perfusion and reverses the skeletal muscle pathology present in PAD. 670 nm light treatment of the lower extremities increases plasma nitrosothiols, a major source of NO activity. In our preliminary study, 670 nm light treatment of the legs acutely increased lower extremity arterial flow and six-minute walk distance in people with PAD. Therefore, we hypothesize that 670 nm light treatment of the legs immediately before walking exercise sessions will acutely increase nitrosothiols and NO and facilitate greater exercise intensity, thereby enhancing the chronic benefits of exercise in people with PAD. The ENLIGHTEN PAD Trial will collect preliminary data to test whether, in people with PAD, daily 670 nm light treatment of the lower extremities immediately before home-based walking exercise sessions improves six-minute walk distance at 4-month follow-up, compared to sham light. In primary aim #1, we will test whether 670 nm light + home-based exercise increases six-minute walk distance more than sham light + home-based exercise at 4-month follow-up. In primary aim #2, we will measure the acute effect of the first treatment of 670 nm light on six-minute walk distance and on walking intensity (measured with the ActiGraph accelerometer) during the six-minute walk. In secondary and exploratory aims, we will delineate biologic pathways by which 670 nm light enhances the benefits of walking exercise, by measuring the effects of 670 nm light on plasma nitrosothiols, leg perfusion, and gastrocnemius muscle health. If our hypotheses are correct, we will use results of this Phase II Trial to design a definitive clinical trial to test whether 670 nm light, a safe, accessible, and well-tolerated therapy, enhances the benefits of exercise, thereby improving mobility and quality of life in the large and growing number of older people disabled by PAD.
用LIGHT增强运动以改善PAD的功能:enlightenment PAD试验

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Mary McGrae McDermott其他文献

159 3D Submillimeter isotropic resolution superficial femoral artery wall MRI using SPACE at 3.0 T
  • DOI:
    10.1186/1532-429x-10-s1-a60
  • 发表时间:
    2008-10-22
  • 期刊:
  • 影响因子:
  • 作者:
    Zhuoli Zhang;Zhaoyang Fan;YiuCho Chung;Peter Weale;Timothy Carroll;Ioannis Koktzoglou;Renate Jerecic;James Carr;Mary McGrae McDermott;Debiao Li
  • 通讯作者:
    Debiao Li
Changes in study design, gender issues, and other characteristics of clinical research published in three major medical journals from 1971 to 1991
  • DOI:
    10.1007/bf02599570
  • 发表时间:
    1995-01-01
  • 期刊:
  • 影响因子:
    4.200
  • 作者:
    Mary McGrae McDermott;Frank Lefevre;Joe Feinglass;Douglas Reifler;Nancy Dolan;Steven Potts;Kathleen Senger
  • 通讯作者:
    Kathleen Senger
Building a research career in general internal medicine
  • DOI:
    10.1046/j.1525-1497.1998.00028.x
  • 发表时间:
    1998-02-01
  • 期刊:
  • 影响因子:
    4.200
  • 作者:
    Marshall H. Chin;Kenneth E. Covinsky;Mary McGrae McDermott;Eric J. Thomas
  • 通讯作者:
    Eric J. Thomas

Mary McGrae McDermott的其他文献

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{{ truncateString('Mary McGrae McDermott', 18)}}的其他基金

Far Red Light to Improve Functioning in PAD: the LIGHT PAD Trial
远红光改善 PAD 功能:LIGHT PAD 试验
  • 批准号:
    10572758
  • 财政年份:
    2023
  • 资助金额:
    $ 26.75万
  • 项目类别:
Response to Exercise and Nitric Oxide in PAD: the RESIST PAD Trial
PAD 对运动和一氧化氮的反应:RESIST PAD 试验
  • 批准号:
    10656845
  • 财政年份:
    2023
  • 资助金额:
    $ 26.75万
  • 项目类别:
BEET root juice to reverse functional impairment in PAD: The BEET PAD Trial
甜菜根汁逆转 PAD 功能损伤:甜菜 PAD 试验
  • 批准号:
    10440812
  • 财政年份:
    2022
  • 资助金额:
    $ 26.75万
  • 项目类别:
Sequential Multiple Assessment Randomized Trial of Exercise for PAD: SMART Exercise for PAD
PAD 运动的序贯多重评估随机试验:PAD 的 SMART 运动
  • 批准号:
    10708097
  • 财政年份:
    2022
  • 资助金额:
    $ 26.75万
  • 项目类别:
BEET root juice to reverse functional impairment in PAD: The BEET PAD Trial
甜菜根汁逆转 PAD 功能损伤:甜菜 PAD 试验
  • 批准号:
    10649671
  • 财政年份:
    2022
  • 资助金额:
    $ 26.75万
  • 项目类别:
FIsetin to Reduce Senescence and mobility impairmenT in PAD: the FIRST Pilot Randomized Trial
非瑟酮可减少 PAD 中的衰老和活动障碍:第一个试点随机试验
  • 批准号:
    10526851
  • 财政年份:
    2022
  • 资助金额:
    $ 26.75万
  • 项目类别:
Sequential Multiple Assessment Randomized Trial of Exercise for PAD: SMART Exercise for PAD
PAD 运动的序贯多重评估随机试验:PAD 的 SMART 运动
  • 批准号:
    10584209
  • 财政年份:
    2022
  • 资助金额:
    $ 26.75万
  • 项目类别:
COCOA flavanols to improve walking performance in PAD: the COCOA-PAD II Trial
可可黄烷醇可改善 PAD 的步行表现:COCOA-PAD II 试验
  • 批准号:
    10430199
  • 财政年份:
    2021
  • 资助金额:
    $ 26.75万
  • 项目类别:
COCOA flavanols to improve walking performance in PAD: the COCOA-PAD II Trial
可可黄烷醇可改善 PAD 的步行表现:COCOA-PAD II 试验
  • 批准号:
    10685352
  • 财政年份:
    2021
  • 资助金额:
    $ 26.75万
  • 项目类别:
COCOA flavanols to improve walking performance in PAD: the COCOA-PAD II Trial
可可黄烷醇可改善 PAD 的步行表现:COCOA-PAD II 试验
  • 批准号:
    10209585
  • 财政年份:
    2021
  • 资助金额:
    $ 26.75万
  • 项目类别:

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