A versatile lens architecture to shape visible light

用于塑造可见光的多功能镜头架构

• 批准号: 10652885
• 负责人: DONALD K ROPER
• 金额: $ 42.92万
• 依托单位: UTAH STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652885
• 关键词: Age; Alzheimer' s Disease; Architecture; Area; Automobile Driving; Aviation; Biomedical Research; Classification; Collaborations; Color; Color Perception; Color Visions; Contact Lenses; Cornea; Cues; Custom; Deposition; Depth Perception; Deterioration; Devices; Disadvantaged; Disease; Dyes; Electron Microscopy; Elements; Emotions; Engineering; Environment; Evaluation; Exhibits; Eye; Fishes; Future; Geometry; Glaucoma; Health; Individual; Inherited; Injections; Lead; Light; Macular degeneration; Measurement; Mentors; Methods; Military Personnel; Minor; Molds; Mormyridae; Motion Perception; Nature; Optics; Outcome; Parkinson Disease; Perception; Performance; Persons; Pharmaceutical Preparations; Preparation; Procedures; Publications; Quality of life; Red-Green Color Blindness; Research; Retina; Severities; Shapes; Side; Specific qualifier value; Spectrum Analysis; Surface; Testing; Variant; Visible Radiation; Vision Disorders; Work; career; design; design,build,test; fabrication; food preparation; improved; lens; manufacture; monocular; nanometer; nanoparticle; notch protein; novel; outcome disparities; polydimethylsiloxane; recruit; retinal rods; self assembly; simulation; submicron; transmission process; undergraduate student

PROJECT SUMMARY This proposal aims to demonstrate a versatile lens architecture to shape light incident on the cornea in order to remedy deuteranomaly, with potential for other vision disorders. Twelve million people in the U.S. are deficient in their ability to discern color differences. This negatively impacts their quality of life for health, emotions, and especially careers. They often have difficulty preparing food, driving, or taking medications. They may be disadvantaged or restricted from certain work in military, aviation, or engineering. While typically inherited, color vision deficiency (CVD) frequently accompanies glaucoma, macular degeneration, Alzheimer’s disease, Parkinson’s disease, and other diseases. Color vision deteriorates markedly with age. There are wide variations in classification of CVD and its severity. So, outcomes from accommodation by standard tinted lenses vary considerably. Many such lenses are bandpass filters. They reduce light incident on the retina across a broad spectral region on either side of the anomaly. This distorts the wearer’s perception of contrast, hue, and intensity. Benefits of monocular bandpass filters are offset by alterations in depth and motion perception. In contrast, an ideal notch filter eliminates transmission across just tens of nanometers (nm) of visible light. This separates peak sensitivities of red and green photopigments which overlap excessively in deuteranomaly. Attempts, however, to make notch filters from dye- or nanoparticle-doped lenses still produce broad reductions in transmission around the target wavelength. This wavelength is approximately 560 nm for red-green color blindness. So, doped filters alter perceived hue, saturation, and brightness relative to normal. Nature offers clues to high-acuity, red-green color vision in the eyes of the elephantnose fish (Gnathonemus petersii). Multilayers of submicron-sized crystal lamellae reflect incident light away from rod photoreceptors. Reflection is wavelength- specific due to submicron spacing between adjacent lamellae. We hypothesize that submicron-spaced optical nodes at the convex surface of a lens can be customized to sharply reduce transmission at a wavelength near 560 nanometers Doing so could improve red-green perception based on the anomaloscopic examination of each person. This proposal would use the PI’s rapid bridging simulations to identify composition, geometry, and spatial arrangement of optical nodes required to improve color perception based on chromaticity. Specified nodes would be synthesized and self-assembled into a template stamped with regularly-spaced cavities with few missing nodes. This uses a method recently demonstrated by the PI. This protolens would be located at the convex surface of a contact lens to integrate into existing contact lens manufacture. Microspectroscopy of the lens-integrated protolens would quantify improvement in color perception. This AREA proposal will recruit 8 diverse undergraduates to collaborate with experts in devices, optoelectronics, simulation, and soft materials to conduct biomedical research that strengthens the research environment at USU and prepares them to lead independent research in future eye health through mentoring, publication, and proposal preparation.

项目摘要 该提议旨在展示一种多功能透镜架构，以使入射在角膜上的光成形，以便补救角膜上的角膜损伤。 氘核异常，可能有其他视力障碍。美国有1200万人缺乏能力， 辨别颜色差异。这对他们的健康，情绪，特别是职业生活质量产生了负面影响。他们 经常有困难准备食物，驾驶，或服用药物。他们可能处于不利地位或受到某些限制 在军事、航空或工程领域工作。虽然通常是遗传性的，但色觉缺陷（CVD）经常伴随着 青光眼、黄斑变性、阿尔茨海默病、帕金森病和其他疾病。色觉恶化 明显随着年龄的增长。 CVD的分类及其严重程度存在很大差异。因此，根据标准着色的 透镜变化很大。许多这样的透镜是带通滤波器。它们减少了入射到视网膜上的光线， 异常点两侧的光谱区域这会扭曲佩戴者对对比度、色调和强度的感知。好处 的单眼带通滤波器被深度和运动感知的改变所抵消。相反，理想陷波滤波器 消除了数十纳米（nm）可见光的传输。这将红色和红色的峰值灵敏度分开， 在氘异常中过度重叠的绿色色素。然而，尝试从染料或染料中制造陷波滤波器， 掺杂纳米颗粒的透镜仍然在目标波长附近产生透射的大幅度降低。该波长 大约560 nm的波长用于红绿色盲。因此，掺杂的过滤器改变感知的色调，饱和度和亮度相对 恢复正常 大自然提供了线索，高敏锐度，红绿色视觉的眼睛象鼻鱼（Gnathonemus petersii）。 多层亚微米尺寸的晶体薄片将入射光反射远离视杆光感受器。反射 由于相邻薄片之间的亚微米间距，我们假设亚微米间距的光学 可以定制透镜的凸表面处的节点以急剧降低在560纳米附近的波长处的透射 这样做可以改善基于每个人的异常检查的红绿感知。这项建议将 使用PI的快速桥接模拟来确定所需光节点的组成、几何形状和空间布置 以改善基于色度的颜色感知。指定的节点将被合成并自组装成一个 模板冲压有规则间隔的空腔，很少有节点缺失。这使用了一种最近由 Pi.该原透镜将位于接触透镜的凸表面处以集成到现有接触透镜制造中。 显微光谱学的透镜集成protolens将量化改善颜色感知。 该区域提案将招募8名不同的本科生，与器件，光电子， 模拟和软材料进行生物医学研究，加强在USU的研究环境，并准备 他们通过指导，出版和提案准备来领导未来眼睛健康的独立研究。