A versatile lens architecture to shape visible light

用于塑造可见光的多功能镜头架构

• 批准号: 10652885
• 负责人: DONALD K ROPER
• 金额: $ 42.92万
• 依托单位: UTAH STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652885
• 关键词: Age; Alzheimer' s Disease; Architecture; Area; Automobile Driving; Aviation; Biomedical Research; Classification; Collaborations; Color; Color Perception; Color Visions; Contact Lenses; Cornea; Cues; Custom; Deposition; Depth Perception; Deterioration; Devices; Disadvantaged; Disease; Dyes; Electron Microscopy; Elements; Emotions; Engineering; Environment; Evaluation; Exhibits; Eye; Fishes; Future; Geometry; Glaucoma; Health; Individual; Inherited; Injections; Lead; Light; Macular degeneration; Measurement; Mentors; Methods; Military Personnel; Minor; Molds; Mormyridae; Motion Perception; Nature; Optics; Outcome; Parkinson Disease; Perception; Performance; Persons; Pharmaceutical Preparations; Preparation; Procedures; Publications; Quality of life; Red-Green Color Blindness; Research; Retina; Severities; Shapes; Side; Specific qualifier value; Spectrum Analysis; Surface; Testing; Variant; Visible Radiation; Vision Disorders; Work; career; design; design,build,test; fabrication; food preparation; improved; lens; manufacture; monocular; nanometer; nanoparticle; notch protein; novel; outcome disparities; polydimethylsiloxane; recruit; retinal rods; self assembly; simulation; submicron; transmission process; undergraduate student

PROJECT SUMMARY This proposal aims to demonstrate a versatile lens architecture to shape light incident on the cornea in order to remedy deuteranomaly, with potential for other vision disorders. Twelve million people in the U.S. are deficient in their ability to discern color differences. This negatively impacts their quality of life for health, emotions, and especially careers. They often have difficulty preparing food, driving, or taking medications. They may be disadvantaged or restricted from certain work in military, aviation, or engineering. While typically inherited, color vision deficiency (CVD) frequently accompanies glaucoma, macular degeneration, Alzheimer’s disease, Parkinson’s disease, and other diseases. Color vision deteriorates markedly with age. There are wide variations in classification of CVD and its severity. So, outcomes from accommodation by standard tinted lenses vary considerably. Many such lenses are bandpass filters. They reduce light incident on the retina across a broad spectral region on either side of the anomaly. This distorts the wearer’s perception of contrast, hue, and intensity. Benefits of monocular bandpass filters are offset by alterations in depth and motion perception. In contrast, an ideal notch filter eliminates transmission across just tens of nanometers (nm) of visible light. This separates peak sensitivities of red and green photopigments which overlap excessively in deuteranomaly. Attempts, however, to make notch filters from dye- or nanoparticle-doped lenses still produce broad reductions in transmission around the target wavelength. This wavelength is approximately 560 nm for red-green color blindness. So, doped filters alter perceived hue, saturation, and brightness relative to normal. Nature offers clues to high-acuity, red-green color vision in the eyes of the elephantnose fish (Gnathonemus petersii). Multilayers of submicron-sized crystal lamellae reflect incident light away from rod photoreceptors. Reflection is wavelength- specific due to submicron spacing between adjacent lamellae. We hypothesize that submicron-spaced optical nodes at the convex surface of a lens can be customized to sharply reduce transmission at a wavelength near 560 nanometers Doing so could improve red-green perception based on the anomaloscopic examination of each person. This proposal would use the PI’s rapid bridging simulations to identify composition, geometry, and spatial arrangement of optical nodes required to improve color perception based on chromaticity. Specified nodes would be synthesized and self-assembled into a template stamped with regularly-spaced cavities with few missing nodes. This uses a method recently demonstrated by the PI. This protolens would be located at the convex surface of a contact lens to integrate into existing contact lens manufacture. Microspectroscopy of the lens-integrated protolens would quantify improvement in color perception. This AREA proposal will recruit 8 diverse undergraduates to collaborate with experts in devices, optoelectronics, simulation, and soft materials to conduct biomedical research that strengthens the research environment at USU and prepares them to lead independent research in future eye health through mentoring, publication, and proposal preparation.

项目总结 这项建议旨在展示一种多功能的镜片结构，以塑造入射到角膜上的光线，以补救 先天异常，有可能出现其他视力障碍。美国有1200万人缺乏 辨别颜色差异。这对他们的健康、情感、尤其是事业的生活质量产生了负面影响。他们 经常在准备食物、开车或服药方面有困难。他们可能处于不利地位或受到某些限制 在军事、航空或工程领域工作。虽然通常是遗传性的，但色觉缺陷(CVD)经常伴随着 青光眼、黄斑变性、阿尔茨海默病、帕金森氏病等疾病。色觉退化 随着年龄的增长明显增加。 脑血管病的分类和严重程度有很大的差异。因此，住宿的结果以标准颜色显示 镜片差别很大。许多这样的镜片都是带通滤光片。它们减少了入射到视网膜上的光线 异常两侧的光谱区域。这会扭曲佩戴者对对比度、色调和强度的感知。优势 单目带通滤光片的深度和运动感知的变化抵消了这一点。相比之下，理想的陷波滤波器 消除了仅通过数十纳米(Nm)可见光的传输。这将红色和红色的峰值灵敏度分开 Deurn异常中过度重叠的绿色感光颜料。然而，尝试用染料或其他物质制造陷波滤光片 纳米颗粒掺杂的透镜仍然会在目标波长附近产生广泛的透射率降低。这个波长是 红绿色盲约560 nm。因此，掺杂滤光片会改变感知的色调、饱和度和相对亮度 恢复正常。 大自然为象鼻鱼(Gnathonemus Petersii)眼睛的高度敏锐性和红绿色视觉提供了线索。 多层亚微米大小的晶片将入射光反射离开杆状感光器。反射是 由于相邻薄片之间的亚微米间隔，因此波长特定。我们假设亚微米间距的光学元件 透镜凸面上的节点可以定制，以大幅减少波长接近560纳米的透射率 这样做可以改善基于每个人的异常检查的红绿感知。这项提议将 使用PI的快速桥接模拟来确定所需光学节点的组成、几何形状和空间排列 提高基于色度的色彩感知。指定的节点将被合成并自组装成一个 模板上印有规则间隔的空腔，几乎没有丢失的节点。这使用了一种最近由 圆周率。这种原形眼镜将位于隐形眼镜的凸面，以整合到现有的隐形眼镜制造中。 集成透镜的显微光谱学将量化颜色感知的改善。 这一领域的提案将招聘8名不同的本科生，与器件、光电子、 模拟和软材料进行生物医学研究，以加强USU的研究环境，并为 他们通过指导、出版和提案准备来领导未来眼睛健康的独立研究。