Multimodal dissociation of posterior cingulate cortex contributions to episodic memory

后扣带皮层多模态分离对情景记忆的贡献

• 批准号: 10652324
• 负责人: Seth Ryan Koslov
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652324
• 关键词: Address; Alzheimer' s Disease; Anatomy; Autobiography; Biological; Cells; Code; Cognition; Cognitive deficits; Complement; Coupled; Data; Data Analyses; Data Collection; Data Set; Decision Making; Disease; Disease Progression; Dissociation; Dorsal; Electrodes; Electrophysiology (science); Episodic memory; Exhibits; Frequencies; Functional Magnetic Resonance Imaging; Hippocampus; Human; Image; Individual; Intervention; Lateral; Link; Literature; Location; Magnetism; Maps; Measurement; Medial; Memory; Memory impairment; Meta-Analysis; Methods; Neocortex; Neurodegenerative Disorders; Neurons; Parietal Lobe; Participant; Pattern; Population; Process; Ramp; Rare Lesion; Research; Research Personnel; Resolution; Response Latencies; Retrieval; Role; Semantics; Signal Transduction; Site; Structure; Surface; Techniques; Temporal Lobe; Testing; Training; Visual; Work; cell type; cingulate cortex; cognitive process; experience; experimental study; healthy aging; improved; insight; memory process; memory retrieval; multimodality; neocortical; neural; neuroimaging; neuropathology; prevent; response; skills; spatiotemporal; theories

Project Summary Episodic memory is the ability to recall details about prior experiences. Researchers have historically relied on controlled item-recognition paradigms, in complement to autobiographical recall tasks, to investigate the biological substrates of episodic memory. Contemporary theories posit that episodic memory is supported by a constellation of neocortical regions, in concert with the hippocampus and medial temporal cortices. Of these neocortical regions, the posterior cingulate cortex (PCC) stands out because it is reliably observed in neuroimaging studies of episodic memory and demonstrates engagement that is sensitive to memory strength. Although a large literature indicates that the PCC is critical for episodic memory, very little is known about its unique role in memory or cognition more broadly. Meta-analyses of functional neuroimaging studies that have investigated the relationship between memory tasks and PCC activations provide some insight as to the region’s role. Strikingly, while item-recognition tasks are associated with activity in the dorsal subregion of the PCC (dPCC), autobiographic recall tasks are uniquely associated with activity in the ventral PCC subregion (vPCC). This functional divide mirrors similar cytoarchitectural and network-connectivity differences found along the dorsal-ventral axis of the PCC. Furthermore, the dPCC is consistently implicated in decision-making studies, while the vPCC has been found to be involved in the representation of specific features and semantic associations of retrieved memories. Synthesizing across previous observations suggests that the dPCC serves as a putative accumulator of mnemonic evidence during memory-based decisions, while the vPCC serves to support the retrieval of details about previous episodes. However, progress in clarifying the contributions of PCC subregions to episodic memory have been stymied due to the location of the region within the medial surface, making it challenging to isolate the dynamics of PCC signals using traditional electrophysiological recording and neuroimaging methods. The use of cutting-edge techniques can help overcome previous limitations in spatiotemporal precision that have prevented advances in understanding the function of the PCC: high-resolution functional neuroimaging and invasive electrophysiological recordings of population and single neuron activity. An openly-available, high-resolution neuroimaging dataset containing thousands of item-recognition trials per participant will be used to isolate the functional organization of item-recognition response patterns in the PCC. Population responses collected via intracranial electrodes will be analyzed in order to temporally isolate tightly coupled memory-decision and memory-retrieval processes across the PCC. Additionally, single unit recordings from the PCC will be collected and used to test whether memory-selective and visual-selective units can be identified in the PCC, underlying population level signals observed in response to memory decisions and retrieval. Results from this work will provide a significant advance to our understanding of functional organization in the PCC, helping map the ways memory deficits can progress in healthy aging and disease.

项目摘要 情景记忆是回忆先前经历细节的能力。研究人员历来依赖于 控制项目识别范式，在补充自传回忆任务，调查 情景记忆的生物基质当代理论认为，情景记忆是由一种 新皮质区的星座，与海马和内侧颞叶皮质一致。这些 在新皮质区，后扣带皮层（PCC）突出，因为它是可靠的观察， 情景记忆的神经影像学研究，并证明参与是敏感的记忆强度。 虽然大量文献表明PCC对情景记忆至关重要，但对其功能知之甚少。 在记忆或认知中的独特作用。功能性神经影像学研究的荟萃分析， 研究记忆任务和PCC激活之间的关系提供了一些见解，该地区的 作用引人注目的是，虽然项目识别任务与PCC背侧子区域的活动有关， 自传体回忆任务与腹侧PCC亚区（vPCC）的活动唯一相关。 这种功能上的差异反映了在沿着 PCC的背腹轴。此外，dPCC一直与决策研究有关， 虽然已经发现vPCC涉及特定特征和语义的表示， 记忆的关联综合以前的观察结果表明，dPCC服务于 在基于记忆的决策过程中，vPCC是记忆证据的推定累积器，而vPCC则用于 支持检索有关以前事件的详细信息。然而，在澄清委员会的贡献方面取得的进展 情景记忆的子区域由于该区域在内侧表面内的位置而受到阻碍， 这使得使用传统的电生理记录来隔离PCC信号的动力学具有挑战性， 神经影像学方法。使用尖端技术可以帮助克服以前的限制， 时空精度阻碍了对PCC功能的理解：高分辨率 功能性神经成像和侵入性电生理记录群体和单个神经元活动。 一个开放的，高分辨率的神经成像数据集，包含数千个项目识别试验， 参与者将被用来隔离PCC中项目识别响应模式的功能组织。 将分析通过颅内电极收集的群体反应，以便在时间上紧密隔离 耦合的记忆决策和记忆检索过程的PCC。此外，单个单元记录 将收集并用于测试记忆选择性和视觉选择性单位是否可以 - 在PCC中识别，响应于记忆决策而观察到的潜在群体水平信号，以及 检索这项工作的结果将为我们对职能组织的理解提供一个重要的进展 在PCC中，帮助绘制记忆缺陷在健康老龄化和疾病中的进展方式。